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Continued constriction of the tibial nerve of the rabbit by a ligature was accompanied by a reduction in maximal motor conduction velocity distal to the ligature, and by a reduction in axonal and total fibre diameter. From the presence of paranodal demyelination and distal fibre degeneration in severely affected nerves, it is suggested that in some instances the change in axonal calibre was part of a progressive distal atrophy which could lead to secondary demyelination and ultimately to “dying-back” of the affected axons.
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- Experimental progressive compression neuropathy in the rabbit.Arch. Neurol. (Chic.). 1971; 24: 358-364
- Electrodiagnosis revisited: Tenth John Stanley Coulter Memorial Lecture.Arch. phys. Med. 1961; 42: 6
- Organo-phosphorus neurotoxicity — A model “dying-back” process comparable to certain human neurological disorders.Guy's Hosp. Rep. 1963; 112: 303-319
- The “dying back” process.Arch. Path. Lab. Med. 1979; 103: 659-664
- The axonal pathology in chronic IDPN intoxication.J. Neuropath. exp. Neurol. 1980; 39: 42-55
- Segmental demyelination secondary to axonal degeneration in uremic neuropathy.in: Proc. Mayo Clin.46. 1971: 400-431
- The nature of myelinated nerve fiber degeneration in dominantly inherited hypertrophic neuropathy.in: Proc. Mayo Clin.49. 1974: 34-39
- Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination.Ann. Neurol. 1981; 9: 575-583
- Conduction velocity and conduction block after experimental ischaemic nerve injury.J. neurol. Sci. 1981; 52: 221-238
- Changes in microtubules and neurofilaments in constricted, hypoplastic nerve fibers.Acta neuropath. (Berl.). 1971; : 216-225
- Adjustment of the myelin sheath to changes in axon caliber.Anat. Rec. 1972; 172: 1-13
- Physical injury to peripheral nerves — Physiologic and electrodiagnostic aspects.in: Proc. Mayo Clin.56. 1981: 361-370
- Conduction in regenerating nerve fibres distal to a constriction.J. Physiol. (Lond.). 1981; 317: 62-63P
- Acute ischaemic neuropathy in the rabbit.J. neurol. Sci. 1979; 44: 19-43
- Recovery of conduction velocity distal to a compressive lesion.J. Neurol. Neurosurg. Psychiat. 1974; 37: 1346-1351
- Myelin sheath responses to alterations in axon caliber.Neurology (Minneap.). 1980; 30: 435
- Altered ratio between axon diameter and myelin sheath thickness in regenerated nerve fibers.Brain Res. 1972; 45: 49-65
- Reappraisal of the model for “bulk axoplasmic flow”.Nature New Biol. 1972; 240: 283-285
- Axonal polyneuropathies.in: Sumner A.J. The Physiology of Peripheral Nerve Disease. W. B. Saunders, Philadelphia, PA1980: 340-357
- Physiological studies of the dying-back phenomenon, Part 1 (Effects of acrylamide on muscle stretch afferents).Brain. 1975; 98: 91-100
- Nerve regeneration in the rat following tubular splicing of severed nerves.Arch. Surg. 1943; 46: 525-547
- The life history of the neuron.J. chron. Dis. 1956; 3: 340-348
- Experiments on the mechanism of nerve growth.J. exp. Zool. 1948; 107: 315-395
- Impairment of growth and myelinization in regenerating nerve fibers subject to constriction.in: Proc. Soc. exp. Biol. Med.55. 1944: 77-80
Accepted: October 29, 1981
Received: September 21, 1981
☆This study was supported financially by the Medical Research Council, the Wellcome Trust and the Brain Research Trust.
☆Based on a paper presented to the Peripheral Nerve Study Group in Shakertown, Kentucky, July 1981.
© 1982 Published by Elsevier Inc.