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Abstract
JC virus (JCV)-induced T antigen developed in the nuclei of approximately 50% of adult
human brain (AHB) cells infected with JCV. Approximately 10% of these T antigen-positive
cells contained glial fibrillary acidic protein (GFAP) and were identified as astrocytes
in immunofluorescence studies. About 50% of these T antigen-positive cells bound antiserum
to fibronectin on their surface and were identified as fibroblasts. No cells binding
antiserum to galactocerebroside (GC), an oligodendrocyte-specific marker, were detected
in infected or non-infected AHB cultures. The cell type of AHB that constitutes the
remaining 40–50% of T antigen-positive cells that are GFAP-, fibronectin- and GC-negative
remains to be determined.
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Article info
Publication history
Accepted:
October 21,
1981
Received in revised form:
August 18,
1981
Received:
June 12,
1981
Footnotes
☆This study was supported in part by Public Health Service Grant NS-11036 from the National Institutes of Health and by grant RG-851B5 from the National Multiple Sclerosis Society.
Identification
Copyright
© 1982 Published by Elsevier Inc.
