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Abstract
We show here that the major glycolipid in myelin, galactocerebroside, is not only
a useful marker for isolated bovine oligodendrocytes but that its quantitation can
serve as a probe for cell differentiation. We have produced in the rabbit antisera
to bovine oligodendroglia, bovine myelin and galactocerebroside. The binding of these
antisera to membrane components of bovine oligodendroglia, bovine thymocytes, mouse
glioma (oligodendroglioma) clonal cell strain G 26-24 and mouse neuroblastoma NB2
A was investigated with [125I]protein A. We found major differences in immunological properties between the mature
oligodendrocyte and clonal lines of oligodendroglioma cells. Differentiation appears
to imply not only the expression of galactocerebroside but also of additional surface
markers that are absent from the neurotumor cell lines.
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Article info
Publication history
Accepted:
February 13,
1980
Received:
January 3,
1980
Footnotes
☆This work was supported by the Swiss Multiple Sclerosis Society and the Swiss National Fund.
Identification
Copyright
© 1980 Published by Elsevier Inc.
