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Abstract
In 40 owl monkeys with hemolytic anemia of unknown etiology, 37 had a myopathy characterized
by focal or diffuse necrosis of sarcoplasm which was eosinophilic and floccular. Phagocytosis
of necrotic fibers and regenerative changes were also observed. The severity of lesions
roughly paralleled the severity of anemia and of centrilobular hepatic necrosis assumed
to be caused by hypoxia. That the myopathy was not caused by anemia per se was suggested
by the finding of mild myopathy in 10 of 24 monkeys known never to have been severely
anemic. Although anemic owl monkeys are known not to be deficient in either vitamin
E or selenium, parenteral vitamin E is partially protective against hemolysis in this
species. The myopathy, which resembled that caused by vitamin E or selenium deficiency
in other species, is probably the result of a metabolic abnormality involving vitamin
E in an unknown way.
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References
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Article info
Publication history
Accepted:
March 26,
1980
Received in revised form:
March 5,
1980
Received:
December 30,
1979
Identification
Copyright
© 1980 Published by Elsevier Inc.
