Advertisement
Research Article| Volume 47, ISSUE 1, P35-48, July 1980

Download started.

Ok

Double discharges of distal origin

Influence on the firing rhythm
DOI:https://doi.org/10.1016/0022-510X(80)90023-4
Double discharges of distal origin
Previous ArticleThe process dynamics of viral and bacterial diseases of the central nervous system
Next ArticleBinocular interaction in the visual evoked response
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Double discharges, or doublets, following the direct M response after peripheral nerve stimulation had a distal origin on the axon and were accompanied by a back-response. This antidromic wave was demonstrated by collision technique or by its occasional recurrent F wave.
      Double discharges (DD) with a long interval between the two components had their origin in one subunit and were transmitted to another by motor axon reflex.
      Increase of the post-doublet interval (PDI) duration during EMG was best explained by invasion of the alpha cell by the back-response and the resetting of a new cycle. This invasion was sometimes followed by a recurrent F wave: a shorter PDI resulted.
      Normal PDI were probably due to blocking of the back-response at the myelinated-non-myelinated junction, without alpha cell invasion: weak or absent Renshaw inhibitory effect on the alpha cell concerned seemed to play a role.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Adams M.E.
        • Miller T.A.
        Site of action of pyrethroids — Repetitive “backfiring” in flight motor units of house fly.
        Pestic. Biochem. Physiol. 1979; 11: 218-231
        • Barakan T.H.
        • Downman C.B.B.
        • Eccles J.C.
        Electric potentials generated by antidromic volleys in quadriceps and hamstring motoneurones.
        J. Neurophysiol. 1949; 12: 393-424
        • Bergmans J.
        The physiology of Single Human Nerve Fibres.
        in: Vander, Louvain1970
        • Bergmans J.
        Physiological observations on single human nerve fibers.
        in: New Developments in Electromyography and Clinical Neurophysiology. Vol. 2. Karger, Basel1973: 89-127
        • Brock L.G.
        • Coombs J.S.
        • Eccles J.C.
        Intracellular recording from antidromically activated motoneurones.
        J. Physiol. (Lond.). 1953; 122: 429-461
        • Calvin W.H.
        • Schwartz P.C.
        Steps in production of motoneuron spikes during rhythmic firing.
        J. Neurophysiol. 1972; 35: 297-310
        • Coombs J.S.
        • Eccles J.C.
        • Fatt P.
        The electrical properties of the motoneurone membrane.
        J. Physiol. (Lond.). 1955; 130: 291-325
        • Denny-Brown D.
        On the nature of postural reflexes.
        in: Proc. roy. Soc. B. Lond. (Biol.). 104. 1929: 252-301
        • Denny-Brown D.
        Interpretation of the electromyogram.
        Arch. Neurol. Psychiat. 1949; 61: 99-128
        • Ebeling P.
        • Gilliatt R.W.
        • Thomas P.K.
        A clinical and electrical study of ulnar nerve lesions in the hand.
        J. Neurol. Neurosurg. Psychiat. 1960; 23: 1-9
        • Eccles J.C.
        The Neurophysiological Basis of Mind — The Principles of Neurophysiology.
        in: Clarendon Press, Oxford1953
        • Eccles J.C.
        The central action of antidromic impulses in motor nerve fibres.
        Pflügers Arch. 1955; 260: 385-415
        • Eccles J.C.
        • Hoff H.E.
        Rhythmic responses of motoneurones.
        J. Physiol. (Lond.). 1931; 71: 21P-22P
        • Eccles J.C.
        • Fatt P.
        • Koketsu K.
        Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motoneurones.
        J. Physiol. (Lond.). 1954; 126: 524-562
        • Egloff-Baer S.
        • Roth G.
        Epthaptic recurrent response in man.
        Europ. Neurol. 1979; 18: 256-260
        • Erlanger J.
        • Blair E.A.
        Observations on repetitive responses in axons.
        J. Physiol. (Lond.). 1935; 114: 328-361
        • Esslen E.
        Electromyographic findings on two types of misdirection of regenerating axons.
        Electroenceph. clin. Neurophysiol. 1960; 12: 738-741
        • Halonen J.-P.
        • Lang A.H.
        • Partanen V.S.J.
        Change in motor unit firing rate after double discharge — An electromyogram study in man.
        Exp. Neurol. 1977; 55: 538-545
        • Hoff H.E.
        • Grant R.S.
        The supernormal period in the recovery cycle of motoneurons.
        J. Neurophysiol. 1944; 7: 305-322
        • Lloyd D.P.C.
        The interaction of antidromic and orthodromic volleys in a segmental spinal motor nucleus.
        J. Neurophysiol. 1943; 6: 143-151
        • Masland R.L.
        • Wigton R.S.
        Nerve activity accompanying fasciculation produced by prostigmin.
        J. Neurophysiol. 1940; 3: 269-275
        • Noebels J.L.
        • Prince D.A.
        Presynaptic origin of penicillin after discharges at mammalian nerve terminals.
        Brain Res. 1977; 138: 59-74
        • Partanen V.S.J.
        Double discharges in neuromuscular diseases.
        J. neurol. Sci. 1978; 36: 377-382
        • Partanen V.S.J.
        Time-locked Phenomena of Human Motor Unit Potentials.
        in: University of Kupio, Kupio1979
        • Partanen V.S.J.
        • Lang A.H.
        An analysis of double discharges in the human electromyogram.
        J. neurol. Sci. 1978; 36: 363-375
        • Renshaw B.
        Influence of discharge of motoneurons upon excitation of neighboring motoneurons.
        J. Neurophysiol. 1941; 4: 167-183
        • Richardson A.T.
        The analysis of muscle action potentials in the differential diagnosis of neuromuscular diseases.
        Arch. phys. Med. 1951; 32: 199-206
        • Richardson A.T.
        Clinical electrodiagnosis.
        in: Proc. roy. Soc. Med.55. 1962: 897-904
        • Riker Jr., W.F.
        • Roberts J.
        • Standaert F.G.
        • Fujimori H.
        The motor nerve terminal as the primary focus for drug-induced facilitation of neuromuscular transmission.
        J. Pharmacol. 1957; 121: 286-312
        • Riker Jr., W.F.
        • Werner G.
        • Roberts J.
        • Kuperman A.
        Pharmacologic evidence for the existence of a presynaptic event in neuromuscular transmission.
        J. Pharmacol. exp. Ther. 1959; 125: 150-158
        • Riker Jr., W.F.
        • Werner G.
        • Roberts J.
        • Kuperman A.
        The presynaptic element in neuromuscular transmission.
        Ann. N.Y. Acad. Sci. 1959; 81: 328-344
        • Roth G.
        Décharge double.
        Schweiz. Arch. Neurol. Neurochir. Psychiat. 1971; 108: 261-272
        • Roth G.
        Fasciculations d'origine périphérique.
        Electromyography. 1971; 11: 413-428
        • Roth G.
        Décharge couplée et réflexe d'axone moteur.
        Electromyography. 1971; 11: 459-463
        • Roth G.
        Décharge double indirecte.
        Electromyogr. clin. Neurophysiol. 1974; 14: 235-241
        • Roth G.
        Intranervous regeneration of lower motor neuron — Study of 1153 motor axon reflexes.
        Electromyogr. clin. Neurophysiol. 1978; 18: 225-351
        • Roth G.
        Intranervous regeneration — The study of motor axon reflexes.
        J. neurol. Sci. 1979; 41: 139-148
        • Roth G.
        • Egloff-Baer S.
        Ephaptic response in man.
        Europ. Neurol. 1979; 18: 261-266
        • Schiller H.H.
        • Stålberg E.
        F-Responses studied with single fibre EMG in normal subjects and spastic patients.
        J. Neurol. Neurosurg. Psychiat. 1978; 41: 45-53
        • Simpson J.A.
        Electrical signs in the diagnosis of carpal tunnel and related syndromes.
        J. Neurol. Neurosurg. Psychiat. 1956; 19: 275-280
        • Simpson J.A.
        Terminology of electromyography.
        Electroenceph. clin. Neurophysiol. 1969; 26: 224-226
        • Stålberg E.
        • Trontelj J.V.
        Single Fibre Electromyography.
        in: The Mirvalle Press, Old Woking, Surrey, Great Britain1979
        • Stålberg E.
        • Schwartz M.S.
        • Trontelj J.V.
        Single fibre electromyography in various processes affecting the anterior horn cell.
        J. neurol. Sci. 1975; 24: 403-415
        • Standaert F.G.
        Post-tetanic repetitive activity in the cat soleus nerve — Its origin, course, and mechanism of generation.
        J. gen. Physiol. 1963; 47: 53-70
        • Takahashi K.
        The “coupling discharge” in neurogenic muscular atrophy.
        Arch. Neurol. (Chic.). 1966; 14: 617-623
        • Taraschi G.
        • Lanzi G.
        Décharges multiples d'une unité motrice durant l'activité volontaire dans un cas de sclérose latérale amyotrophique.
        Electroenceph. clin. Neurophysiol. 1962; : 146
        • Trontelj J.V.
        • Trontelj M.
        F-Responses of human facial muscles — A single motoneurone study.
        J. neurol. Sci. 1973; 20: 211-222
        • Valle M.
        Décharges multiples dans la poliomyélite par mécanismes fonctionnels non-reconductibles à cryptotétanie.
        Electroenceph. clin. Neurophysiol. 1962; : 144-146
        • Werner G.
        Neuromuscular facilitation and antidromic discharges in motor nerves — Their relation to activity in motor nerve terminals.
        J. Neurophysiol. 1960; 23: 171-187
        • Werner G.
        Generation of antidromic activity in motor nerves.
        J. Neurophysiol. 1960; 23: 454-461
        • Wiersma C.A.G.
        Muscles consisting of a single motor unit after poliomyelitis.
        in: Proc. Soc. exp. Biol. (N.Y.). 61. 1964: 85-89

      Article info

      Publication history

      Accepted: February 22, 1980
      Received: November 26, 1979

      Identification

      DOI: https://doi.org/10.1016/0022-510X(80)90023-4

      Copyright

      © 1980 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX