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Research Article| Volume 27, ISSUE 4, P459-484, April 1976

Multiple sclerosis amongst Chinese in Taiwan

DOI:https://doi.org/10.1016/0022-510X(76)90214-8
Multiple sclerosis amongst Chinese in Taiwan
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      Abstract

      Twenty-five cases of multiple sclerosis (MS), including 2 autopsy cases, collected during the past 20 years from amongst the Chinese of Taiwan, are reported. These cases fulfilled all the clinical diagnostic criteria of MS.
      The following observations were made:
      • 1.
        (1) Multiple sclerosis does exist among Chinese in Taiwan. It is uncommon, but is by no means a very rare disease. The prevalence rate in northern Taiwan near Taipei is estimated as Math Eq population.
      • 2.
        (2) Female preponderence was conspicuous (F:M = 3.2:1) in our MS cases as well as in other demyelinating diseases.
      • 3.
        (3) On the whole, the onset of the disease was earlier in female patients, and those who had their initial symptoms before the age of 20 years were all females.
      • 4.
        (4) The optic nerve was most frequently involved at the onset, and it was involved in the majority of patients during the whole clinical course.
      • 5.
        (5) Involvement of the optic nerve and spinal cord, with or without the brain stem, was the commonest form of our MS cases, especially among female patients.
      • 6.
        (6) More malignant forms of MS, with acute onset and rapid clinical course leading to severe incapacity or fatality, were more common among female patients.
      • 7.
        (7) Painful tonic spasms were relatively frequently encountered, and they were usually seen in patients with severe spinal cord involvement.
      • 8.
        (8) Marked elevation of the CSF total protein and of leukocytes was relatively frequent during severe relapses in patients with spinal cord lesions.
      • 9.
        (9) Severe and extensive demyelinating lesions, both old and recent, in the optic nerve and spinal cord were seen in 2 autopsy cases. The relationship between MS and NMO in Oriental patients is briefly discussed.
      • 10.
        (10) It seems likely that cases of MS which are atypical as compared with Western MS are more frequently seen in Oriental countries, and perhaps also in tropical regions where MS is known to be rare.
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      References

        • Acheson E.D.
        Epidemiology.
        in: McAlpine D. Lumsden C. Acheson E. Multiple Sclerosis — A Reappraisal, Part I. 2nd ed. Churchill Livingstone, London1972: 3-82
        • Adams D.K.
        • Sutherland S.M.
        • Fletcher W.B.
        Early clinical manifestations of disseminated sclerosis.
        Brit. med. J. 1950; 2: 431-436
        • Alter M.
        • Okihiro M.
        • Rowley W.
        • Morris T.
        Multiple sclerosis among Orientals and Caucasians in Hawaii.
        Neurology (Minneap.). 1971; 21: 122-130
        • Barlow J.S.
        Multiple sclerosis in North Korea and China.
        Neurology (Minneap). 1967; 17: 802-812
        • Chiavacci L.V.
        • Hoff H.
        • Polvan N.
        Frequency of multiple sclerosis in greater New York.
        Arch. Neurol. Psychiat. (Chic.). 1950; 64: 546-553
        • Cloys D.E.
        • Netzky M.G.
        Neuromyelitis optica.
        in: Vinken P.J. Bruyn G.W. Handbook of Clinical Neurology, Vol. 9 (Multiple Sclerosis and other Demyelinating Diseases). North-Holland Publishing Co, Amsterdam1970: 426-436 (Ch. 14)
        • Dastur D.K.
        • Singhal B.S.
        Two unusual neuropathologically proven cases of multiple sclerosis from Bombay.
        J. neurol. Sci. 1973; 20: 397-414
        • Gudmundsson K.R.
        Clinical studies of multiple sclerosis in Iceland — A follow-up of previous survey and reappraisal.
        Acta neurol. scand. 1971; 47: 1-78
        • Gwee A.L.
        • Ransome G.A.
        Neurological disorders in Singapore.
        in: Spillane J.D. Tropical Neurology. Oxford University Press, London1973: 283-298
        • Howell D.A.
        • Jellinek E.H.
        • Gavrilescu K.
        Demyelinating disease in a woman from tropical South America with features of multiple sclerosis and neuromyelitis optica — Clinical, protein chemistry and pathological findings.
        J. neurol. Sci. 1968; 7: 115-135
        • Hung T.P.
        • Lin T.Y.
        Multiple sclerosis in Taiwan.
        J. Formosan Med. Ass. 1956; 55: 578-586
        • Hyllested K.
        Lethality, duration and mortality of disseminated sclerosis in Denmark.
        Acta psychiat. scand. 1961; 36: 553-564
        • Ivers R.R.
        • Goldstein N.P.
        Multiple sclerosis: a current appraisal of symptoms and signs.
        in: Proc. Mayo Clin.38. 1963: 457-466
        • Kurland L.T.
        The epidemiologic characteristics of multiple sclerosis.
        in: Vinken P.J. Bruyn G.W. Handbook of Clinical Neurology, Vol. 9, (Multiple Sclerosis and other Demyelinating Diseases). North-Holland Publishing Co, Amsterdam1970: 63-84 (Ch. 4)
        • Kuroiwa Y.
        • Okihiro M.M.
        Multiple sclerosis in Hawaii — A preliminary report.
        Hawaii med. J. 1969; 28: 374-376
        • Kuroiwa Y.
        • Shibasaki H.
        Clinical studies of multiple sclerosis in Japan, Part 1 (A current appraisal of 83 cases).
        Neurology (Minneap.). 1973; 23: 609-617
        • Kurtzke J.F.
        General features of the prevalence of multiple sclerosis.
        J. Indian. med. Prof. 1964; 11: 4896-4901
        • Kurtzke J.F.
        General features of the prevalence of multiple sclerosis.
        J. Indian. med. Prof. 1964; 11: 4895
        • Kurtzke J.F.
        A reassessment of the distribution of multiple sclerosis.
        Acta neurol. scand. 1975; 51 (Part 1): 110-136
        • Kurtzke J.F.
        A reassessment of the distribution of multiple sclerosis.
        Acta neurol. scand. 1975; 51 (Part 2): 137-157
        • Kurtzke J.F.
        • Park C.S.
        • Oh S.J.
        Multiple sclerosis in Korea — Clinical feature and prevalence.
        J. neurol. Sci. 1968; 6: 463-481
        • Leibowitz V.
        • Kahana E.
        • Alter M.
        Survival and death in multiple slcerosis.
        Brain. 1969; 92: 115-130
        • Lumsden C.E.
        Neuropathology of multiple sclerosis.
        in: Vinken P.J. Bruyn G.W. Handbook of Clinical Neurology, Vol. 9, (Multiple Sclerosis and Other Demyelinating Diseases). North-Holland Publishing Co, Amsterdam1970: 217-309 (Ch. 8)
        • Lumsden C.E.
        The clinical pathology of multiple sclerosis.
        in: McAlpine D. Lumsden C.E. Acheson E.D. Multiple Sclerosis — A Reappraisal, Part III. 2nd edition. Churchill Livingstone, London1972: 322-398 (Ch. 13–15)
        • McAlpine D.
        The benign form of multiple sclerosis — A study based on 241 cases seen within three years of onset and followed up until the tenth year or more of the disease.
        Brain. 1961; 84: 186-203
        • McAlpine D.
        Clinical studies.
        in: McAlpine D. Lumsden C.E. Acheson E.D. Multiple Sclerosis — A Reappraisal, Part III. 2nd edition. Churchill Livingstone, London1972: 83-276
        • Mathew N.T.
        • Mathai K.V.
        • Abraham J.
        • Taori G.M.
        Incidence and pattern of demyelinating disease in India.
        J. neurol. Sci. 1971; 13: 27-38
        • Matthews W.B.
        Tonic seizures in disseminated sclerosis.
        Brain. 1958; 81: 193-206
        • Müller R.
        Studies on disseminated sclerosis with special reference to symptomatology, course and prognosis.
        Acta med. scand. 1949; 133: 1-214
        • Okinaka S.
        • Kuroiwa Y.
        Multiple sclerosis and allied diseases in Japan — Epidemiological and clinical aspects.
        in: correlative Neurosciences, Part B: Clinical Studies. Progress in Brain Research. Vol. 21B. Elsevier Publishing Co, Amsterdam1966: 183-191
        • Okinaka S.
        • Tsubaki T.
        • Kuroiwa Y.
        • Toyokura Y.
        • Imamarua Y.
        • Yoshikawa M.
        Multiple sclerosis and its allied diseases in Japan — Clinical characteristics.
        Neurology (Minneap.). 1958; 8: 756-763
        • Okinaka S.
        • McAlpine D.
        • Miyagawa K.
        • Suwa N.
        • Kuroiwa Y.
        • Shiraki H.
        • Araki S.
        • Kurland L.T.
        Multiple sclerosis in northern and southern Japan.
        Wld Neurol. 1960; 1: 22-42
        • Park C.S.
        Multiple sclerosis in Korea.
        Neurology (Minneap.). 1966; 16: 919-926
        • Poser C.M.
        Diseases of the myelin sheath.
        in: Pathology of the Nervous System. Vol. 1. McGraw-Hill, New York, N.Y1968: 767-779 (Ch. 60)
        • Schumacher G.A.
        • Beebe G.
        • Kibler R.F.
        • Kurland L.T.
        • Kurtzke J.F.
        • McDowell F.
        • Nagler B.
        • Sibley W.A.
        • Tourtellotte W.W.
        • Willmon T.L.
        Problems of experimental trials of therapy in multiple sclerosis.
        Ann. N. Y. Acad. Sci. 1965; 122: 552-568
        • Selby S.
        Neurological disorders in Malaysia.
        in: Spillane J.D. Tropical Neurology. Oxford University Press, London1973: 299-320
        • Shibasaki H.
        • Kuroiwa Y.
        Statistical analysis of multiple sclerosis and neuromyelitis optica based on autopsied cases in Japan.
        Folia psychiat. neurol. jap. 1969; 23: 1-10
        • Shibasaki H.
        • Kuroiwa Y.
        Clinical studies of multiple sclerosis in Japan, Part 2 (Are its clinical characteristics changing?).
        Neurology (Minneap.). 1973; 23: 618-622
        • Shibasaki H.
        • Kuroiwa Y.
        Painful tonic seizure in multiple sclerosis.
        Arch. Neurol. (Chic.). 1974; 30: 47-51
        • Shiraki H.
        • Yamamoto T.
        • Hamada S.
        Pathoanatomical studies on neuromyelitis optica and demyelinating myelitis in Japan — The relationship of neuromyelitis optica to multiple sclerosis.
        Psychiat. Neurol. Jap. 1958; 60: 1-49
        • Tourtellotte W.W.
        Cerebrospinal fluid in multiple sclerosis.
        in: Handbook of Clinical Neurology, Vol. 9 (Multiple Sclerosis and Other Demyelinating Diseases). North-Holland Publishing Co, Amsterdam1970: 324-382 (Ch. 11)
        • Vejjajiva A.
        Multiple sclerosis in Thailand.
        Clin. Neurol. (Tokyo). 1970; 10: 36-40
        • Vejjajiva A.
        Neurology in Thailand.
        in: Spillane J.D. Tropical Neurology. Oxford University Press, London1973: 335-352
        • Woods A.H.
        The nervous diseases of the Chinese.
        Arch. Neurol. Psychiat. (Chic.). 1929; 21: 542-570

      Article info

      Publication history

      Received: July 28, 1975

      Identification

      DOI: https://doi.org/10.1016/0022-510X(76)90214-8

      Copyright

      © 1976 Published by Elsevier Inc.

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