Advertisement
Research Article| Volume 27, ISSUE 4, P413-425, April 1976

Multiple sclerosis and cell-mediated hypersensitivity to myelin A1 protein

  • William Shermata
    Correspondence
    Reprint requests to William Sheremata, M.D., Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
    Affiliations
    The Montreal Neurological Institute, McGill University, Montreal, P.Q. Canada

    the Department of Neurology and Neurosurgery, McGill University, Montreal, P.Q. Canada
    Search for articles by this author
  • J.B.R. Cosgrove
    Affiliations
    The Montreal Neurological Institute, McGill University, Montreal, P.Q. Canada

    the Department of Neurology and Neurosurgery, McGill University, Montreal, P.Q. Canada
    Search for articles by this author
  • E.H. Eylar
    Affiliations
    The Montreal Neurological Institute, McGill University, Montreal, P.Q. Canada

    the Department of Neurology and Neurosurgery, McGill University, Montreal, P.Q. Canada
    Search for articles by this author
DOI:https://doi.org/10.1016/0022-510X(76)90212-4
Multiple sclerosis and cell-mediated hypersensitivity to myelin A1 protein
Next ArticleChronic relapsing polyneuritis
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Cellular hypersensitivity to myelin basic (A1) protein was evaluated using the MIF assay in 246 subjects. Of 100 with multiple sclerosis positive results are seen in relationship to acute exacerbations of illness. Normal control subjects gave a mean value of 100 ± 9% whereas patients studied within 4 weeks of onset of illness gave a result of 59 ± 12.5%. A convalescent group studied between 5 and 12 weeks after an attack gave results of 86 ± 22.2%. A chronic group gave a mean of 91 ± 8.2%. Positive values were also seen in a number of other patients with central or peripheral nervous system disease especially those with “autoimmune disease”. However, results of this study clearly establish a temporal relationship between in vitro evidence of hypersensitivity to A1 protein and clinical expression of disease.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Alvord Jr., E.C.
        Acute disseminated encephalomyelitis and “allergic” encephalopathies.
        in: Vinken P.J. Bruyn G.W. Handbook of Clinical Neurology, Vol. 9 (Multiple Sclerosis and other Demyelinating Diseases). North-Holland Publishing Co, Amsterdam1970: 500-571
        • Aström K.E.
        • Waksman B.H.
        The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells.
        J. path. Bact. 1962; 83: 89-106
        • Bartfeld H.
        • Atoynatan T.
        • Donnenfeld H.
        In vitro cellular immunity to nervous system antigens in multiple sclerosis.
        in: Wolfgram F. Andrews J.M. Ellison G.W. Stevens J.A. Multiple Sclerosis — Immunology, Virology and Ultrastructure. Academic Press, New York, N.Y1972: 333-364
        • Becus T.
        • Gyargyay-Malatinski E.
        • Kovacs V.
        Transformation of lymphocytes of patients with multiple sclerosis after treatment with phytoaglutinins.
        Neurol. Psihiat. Neurochir. 1973; 18: 367-375
        • Behan P.O.
        • Lamarche J.
        • Geschwind N.
        Delayed hypersensitivity to encephalitogenic protein in disseminated encephalomyelitis.
        Lancet. 1968; 2: 1009-1012
        • Behan P.O.
        • Behan W.M.H.
        • Feldman R.G.
        • Kies M.W.
        Cell mediated hypersensitivity to neural antigens — Occurrence in human patients and nonhuman primates with neurological diseases.
        Arch. Neurol. (Chic.). 1972; 27: 145-152
        • Behan P.O.
        • Kies M.W.
        • Lisak R.P.
        • Sheremata W.
        • Lamarche J.B.
        Immunological mechanisms in experimental encephalomyelitis in nonhuman primates.
        Arch. Neurol. (Chic.). 1973; 29: 4-9
        • Behan P.O.
        • Lisak R.P.
        • Zweiman B.
        • Shetty T.
        • Kies M.W.
        Cell mediated immunity to myelin basic protein in acute disseminated encephalomyelitis.
        Neurology (Minneap.). 1973; 23: 422
        • Bogaert L.van
        Post infectious encephalomyelitis and multiple sclerosis — Significance of perivenous encephalomyelitis.
        J. Neuropath. exp. Neurol. 1950; 9: 219-249
        • Brody J.A.
        • Harlem M.H.
        • Kurtzke J.F.
        • White L.R.
        Unsuccessful attempt to induce transformation by cerebrospinal fluid in cultured lymphocytes from patients with multiple sclerosis.
        New Engl. J. Med. 1968; 279: 202-204
        • Brostoff S.W.
        • Eylar E.H.
        Proposed amino acid sequence of P1 protein of rabbit sciatic nerve myelin.
        Arch. Biochem. Biophys. 1971; 153: 783-793
        • Dau P.C.
        • Peterson R.D.A.
        Transformation of lymphocytes from patients with multiple sclerosis — Use of encephalitogen of human origin, with a report of a trial of immunosuppressant therapy in multiple sclerosis.
        Arch. Neurol. (Chic.). 1970; 23: 32-40
        • Davis F.A.
        • Becker F.O.
        • Michael J.A.
        • Sorensen E.
        Effect of intravenous sodium bicarbonate, disodium edetate (Na2EDTA), and hyperventilation on visual and oculomotor signs in multiple sclerosis.
        J. Neurol. Neurosurg. Psychiat. 1970; 33: 723-732
        • Day J.H.
        • Day M.P.
        Specific migration inhibition of lymphocytes in multiple sclerosis — A possible diagnostic test (Abstr.).
        Ann. roy. Coll. Phys. Surg. 1975; 8: 63-64
        • Eylar E.H.
        • Brostoff S.
        • Hashim G.
        • Caccam J.
        • Burnett P.
        Basic A1 protein of the myelin membrane — The complete amino acid sequence.
        J. biol. Chem. 1971; 246: 5770-5784
        • Hochberg F.H.
        • Leahrich J.R.
        • Arnason B.G.W.
        Recurrent EAE induced by herpes simplex virus infection (Abstr.).
        Neurology (Minneap.). 1974; 24: 384
        • Hughes D.
        • Caspary E.A.
        • Field E.J.
        Lymphocyte transformation induced by encephalitogenic factor in multiple sclerosis and other neurological disease.
        Lancet. 1968; 2: 1205-1207
        • Jensen M.K.
        Lymphocyte transformation in multiple sclerosis.
        Acta neurol. scand. 1968; 44: 200-206
        • Kaprowski H.
        • LeBell I.
        Presence of complement fixing antibodies against brain tissue in serum of persons who had received antirabies vaccine treatments.
        Amer. J. Hyg. 1950; 51: 292-299
        • Kies M.W.
        • Alvord Jr., E.C.
        Prevention of allergic encephalomyelitis by prior injection of adjuvants.
        Nature (Lond.). 1958; 182: 106
        • Levine S.
        • Wenk E.J.
        Rapid passive transfer of allergic encephalomyelitis.
        J. Immunol. 1967; 99: 1277-1285
        • McFarlin D.E.
        • Blank S.E.
        • Kibler R.F.
        Recurrent experimental allergic encephalomyelitis in the Lewis rat.
        J. Immunol. 1974; 113: 712-715
        • Meyers L.W.
        Leukocyte migration inhibition in multiple sclerosis.
        in: Wolfgram F. Ellison G.W. Stevens J.A. Andrews J.M. Multiple Sclerosis — Immunology, Virology, and Ultrastructure. Academic Press, New York, N.Y1972: 383-399
        • Meyers L.W.
        • Ellison G.W.
        Effect of humoral factors on cellular hypersensitivity to nervous tissue in multiple sclerosis.
        in: Fed. Proc.32. 1973: 832
        • Patten B.M.
        • Hart A.
        • Lovelace R.
        Multiple sclerosis associated with defects in neuromuscular transmission.
        J. Neurol. Neurosurg. Psychiat. 1972; 35: 385-394
        • Patterson P.Y.
        Transfer of allergic encephalomyelitis in rats by means of lymph node cells.
        J. exp. Med. 1960; 111: 119-136
        • Rivers T.M.
        • Schwenker F.F.
        Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys.
        J. exp. Med. 1935; 61: 689-702
        • Rivers T.M.
        • Sprunt D.H.
        • Berry G.P.
        Observations on attempts to produce acute disseminated encephalomyelitis in monkeys.
        J. exp. Med. 1933; 58: 39-58
        • Rocklin R.E.
        • Ratcliffe H.E.
        Antigen-induced production of migration inhibition factor (MIF) by non-dividing human lymphocytes.
        in: Fed. Proc.31. 1972: 753
        • Rocklin R.E.
        • Meyers O.L.
        • David J.R.
        An in vitro assay for cellular hypersensitivity in man.
        J. Immunol. 1970; 104: 95-102
        • Rocklin R.E.
        • Sheremata W.A.
        • Feldman R.G.
        • Kies M.W.
        • David J.R.
        Guillain-Barré and multiple sclerosis — In vitro cellular responses to nervous tissue antigens.
        New Engl. J. Med. 1971; 284: 803-808
        • Sachs H.
        • Steiner G.
        Serologische Untersuchungen bei Multipler Sklerose.
        Klin. Wschr. 1934; 13: 1714-1717
        • Shaw C.M.
        • Alvord Jr., E.C.
        • Kaku J.
        • Kies M.W.
        Correlation of experimental allergic encephalomyelitis with delayed-type skin sensitivity to specific homologous encephalitogen.
        Ann. N.Y. Acad. Sci. 1965; 122: 318-331
        • Søberg M.
        • Bendixen G.
        Human lymphocyte migration as a parameter of hypersensitivity.
        Acta med. scand. 1967; 181: 247
        • Sheremata W.
        • Cosgrove J.B.R.
        • Eylar E.H.
        Cellular hypersensitivity to basic myelin (A1) protein and clinical multiple sclerosis.
        New Engl. J. Med. 1974; 291: 14-17
        • Strandsgaard W.
        • Jørgensen P.N.
        Delayed hypersensitivity to myelin antigen in multiple sclerosis investigated with the leukocyte migration method.
        Acta neurol. scand. 1972; : 243-248
        • Thor D.E.
        • Jureziz R.E.
        • Veach S.R.
        • Miller E.
        • Dray S.
        Cell migration inhibition factor released by antigen from human peripheral lymphocytes.
        Nature (Lond.). 1968; 219: 755-757
        • Van den Noort S.
        • Stjernholm R.L.
        Lymphotoxicity activity in multiple sclerosis.
        Neurology (Minneap.). 1971; 21: 783-793

      Article info

      Publication history

      Received: July 22, 1975

      Footnotes

      ☆This work was supported by a grant (MA-5171) from the Medical Research Council of Canada.

      Identification

      DOI: https://doi.org/10.1016/0022-510X(76)90212-4

      Copyright

      © 1976 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX