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Immunoglobulin G distribution in multiple sclerosis brain

An immunofluorescence study
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      Abstract

      The distribution of IgG in MS brains (plaques and normal zones) was studied with immunofluorescence. The histological activity was evaluated on alternate serial sections.
      The following results were achieved: high levels of IgG were usually connected with old plaques; IgG could also be observed in normal white matter, especially near old plaques. In recent plaques IgG was found to be absent or at very low levels, while higher levels of IgG were noticeable in the surrounding, apparently normal, areas. Finally it was observed that IgG can be completely removed from the tissue with a brief washing in physiological saline before fixation.
      The results are discussed and it is suggested that IgG in MS brains is acting more as a protective than as an autoimmune antibody.
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