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Abstract
In the Guillain-Barré syndrome (GBS), increased concentrations of the immunoglobulins
A and M, and less frequently of immunoglobulin G, expressed as a percentage of the
total protein concentration were found in cerebrospinal fluid (CSF). The serum concentrations
of these 3 immunoglobulins were normal. One or two discrete bands, probably consisting
of oligoclonal immunoglobulins, were demonstrated in the γ region of serum and CSF
in 8 of the 12 GBS patients investigated. The discrete serum and CSF γ bands have
identical electrophoretic mobilities and are probably transient. High relative concentrations
of the 3 immunoglobulins in CSF were especially found in specimens obtained early
in the course of GBS; they varied independently of the relative albumin concentrations
in CSF. These results indirectly point to a synthesis of the immunoglobulins G, A,
and M within the central nervous system in GBS. The demonstration of quantitative
immunoglobulin abnormalities and of discrete γ bands on electrophoresis is suggested
as having diagnostic implications and also indirectly pointing to the involvement
of humoral antibodies in GBS.
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Article info
Publication history
Received:
June 26,
1972
Footnotes
☆This study was supported by the Swedish Medical Research Council (Project No. B-72-16X-3381-02B).
Identification
Copyright
© 1973 Published by Elsevier Inc.
