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From the fundamentals of multiple sclerosis to clinical management
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Oscar Fernández,
Patrick Vermersch
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S1-S2
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Autoimmune disease in the brain – how to spot the culprits and how to keep them in check
Summary: Current concepts attribute an early and central role for auto-aggressive, myelin-specific T-lymphocytes in the pathogenesis of multiple sclerosis. This view emerged from immunological and pat...
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Alexander Flügel,
Christian Schläger,
Fred Lühder,
Francesca Odoardi
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S3-S11
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Untapped targets in multiple sclerosis
Summary: Multiple sclerosis is a chronic inflammatory disease of the white and grey matter which results in irrevocable axonal and neuronal damage. Grey matter injury is widespread and reflects disabi...
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Edgar Meinl
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S12-S15
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MRI measures of neuroprotection and repair in multiple sclerosis
Summary: Magnetic resonance imaging (MRI) has had an enormous impact on multiple sclerosis, enabling early diagnosis and providing surrogate markers for monitoring treatment response in clinical trial...
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Matilde Inglese
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S16-S23
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Early treatment in multiple sclerosis
Summary: There is now a consensus that early treatment of patients with relapsing–remitting multiple sclerosis is desirable, mainly because early treatment may delay the accumulation of disability, bu...
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Irina Elovaara
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S24-S28
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Balancing the benefits and risks of disease-modifying therapy in patients with multiple sclerosis
Summary: Balancing efficacy versus burden of therapy is essential for the choice of disease-modifying therapy in every MS patient. The first-line therapies, interferon–? and glatiramer acetate, have w...
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Per Soelberg Sørensen
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S29-S34
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Review of methodological issues of clinical trials in multiple sclerosis
Summary: There are currently six approved disease-modifying therapies available to the physician for the treatment of multiple sclerosis. Their efficacy on clinical and radiological parameters has bee...
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Xavier Montalban
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S35-S42
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Rehabilitation and multiple sclerosis: hot topics in the preservation of physical functioning
Summary: In a chronic and disabling disease like multiple sclerosis, rehabilitation becomes of major importance in the preservation of physical, psychological and social functioning. Approximately 80%...
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Ulrik Dalgas
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S43-S47
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Symptom management in patients with multiple sclerosis
Summary: Multiple sclerosis is a complex disease associated with a wide variety of different symptoms that can affect the ability of multiple sclerosis patients to carry out normal activities of daily...
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Tjalf Ziemssen
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S48-S52
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Multiple sclerosis in childhood and adolescence
Summary: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system, typically manifesting in young adults. However, it can be identified in children in all age g...
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Silvia Tenembaum
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S53-S57
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