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Editorial Board
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| Review |
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Implementing clinical trials on an international platform: Challenges and perspectives
03 November 2011
Abstract: The importance of conducting medical research on a global or international platform cannot be overemphasized in current times. Sponsors are encouraging international clinical trials for a nu...
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Greg Minisman,
Minal Bhanushali,
Robin Conwit,
Gil I. Wolfe,
Inmaculada Aban,
Henry J. Kaminski,
Gary Cutter
et al.
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1-6
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| Original Articles |
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Functional neuroanatomy of vocalization in patients with Parkinson's disease
11 November 2011
Abstract: In Parkinson's disease (PD) both speech production and self-monitoring of voiced speech are altered. Methods: In our previous study we used functional magnetic resonance imaging (fMRI) to ex...
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I. Rektorova,
M. Mikl,
J. Barrett,
R. Marecek,
I. Rektor,
T. Paus
et al.
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7-12
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Visuo-spatial interference affects the identification of emotional facial expressions in unmedicated Parkinson's patients
26 October 2011
Abstract: There is evidence that visuo-spatial capacity can become overloaded when processing a secondary visual task (Dual Task, DT), as occurs in daily life. Hence, we investigated the influence of ...
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Beatriz García-Rodríguez,
Carmen Casares Guillén,
Rosa Jurado Barba,
Gabriel Rubio Valladolid,
José Antonio Molina Arjona,
Heiner Ellgring
et al.
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13-16
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Immunization with a new DNA vaccine for Alzheimer's disease elicited Th2 immune response in BALB/c mice by in vivo electroporation
26 October 2011
Abstract: Immunization with synthetic amyloid β-protein (Aβ) peptide has resulted in preventing and clearing Aβ deposits as well as improving cognitive function in transgenic mouse models of Alzheimer...
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Xiaona Xing,
Sha Sha,
Yu Li,
Lixia Zong,
Tongzi Jiang,
Yunpeng Cao
et al.
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17-21
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Cilostazol combined with aspirin prevents early neurological deterioration in patients with acute ischemic stroke: A pilot study
20 October 2011
Abstract: Recent randomized trials have shown that cilostazol is superior to aspirin for secondary stroke prevention. We hypothesized that combining cilostazol with aspirin is more effective than aspi...
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Tomomi Nakamura,
Shinji Tsuruta,
Shinichiro Uchiyama
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22-26
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Different molecular expression in thymoma with ocular or generalized myasthenia gravis
17 October 2011
Abstract: Background: Increasing evidence supports a link between expressions of CD4, CD25, Foxp3, and CXCL13 in thymic hyperplasia with myasthenia gravis (MG) patients. Herein, we investigated the ex...
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Min Zhang,
Hongzeng Li,
Jun Guo,
Yongan Zhou,
Li Gong,
Xianni Wang,
Zhuyi Li,
Wei Zhang
et al.
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27-31
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Reversible propriospinal myoclonus due to thoracic disc herniation: Long-term follow-up
24 October 2011
Abstract: PSM is a rare form of myoclonus of spinal origin. The thoracic level is considered as the myoclonic generator in most cases; however, structural abnormality in conventional magnetic resonanc...
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Wooyoung Jang,
Joong-Seok Kim,
Jin Young Ahn,
Hee-Tae Kim
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32-34
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Reflexive and volitional saccades: Biomarkers of Huntington disease severity and progression
24 October 2011
Abstract: Background: Huntington disease (HD) is a genetic, neurodegenerative disorder characterized by chorea, behavioral co-morbidities, cognitive deficits, and eye movement abnormalities. We sought...
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Saumil S. Patel,
Joseph Jankovic,
Ashley J. Hood,
Cameron B. Jeter,
Anne B. Sereno
et al.
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35-41
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Clinical features and recovery patterns of acquired non-thyrotoxic hypokalemic paralysis
17 October 2011
Abstract: Objective: To report the clinical features and recovery patterns of patients with non-thyrotoxic acquired hypokalemic paralysis. Methods: The clinical and laboratory records of 11 consecutiv...
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Akiyuki Hiraga,
Ikuo Kamitsukasa,
Kazuho Kojima,
Satoshi Kuwabara
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42-45
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External carotid artery branches involvement in reversible cerebral vasoconstriction syndrome
17 October 2011
Abstract: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by segmental vasoconstriction and dilatation of intracranial arteries, usually revealed by headaches, which spontaneousl...
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E. Melki,
C. Denier,
M. Théaudin-Saliou,
M. Sachet,
D. Ducreux,
G. Saliou
et al.
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46-47
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Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis
31 October 2011
Abstract: Objective: Neuromyelitis optica (NMO) is characterized by selective inflammation of the spinal cord and optic nerves but is distinct from multiple sclerosis (MS). Interferon (IFN)-β mitigate...
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Xuan Feng,
Nicholas P. Reder,
Mounica Yanamandala,
Addie Hill,
Beverly S. Franek,
Timothy B. Niewold,
Anthony T. Reder,
Adil Javed
et al.
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48-53
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Widespread cerebral cortical mineralization in Wilson's disease detected by susceptibility-weighted imaging
24 October 2011
Abstract: Signal abnormalities of cortical gray matter, compared with the deep nuclear structures, have received less attention in Wilson's disease (WD). They nearly always accompanied white matter si...
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Jae-Hyeok Lee,
Tae-Il Yang,
Mong Cho,
Ki-Tae Yoon,
Seung-Kug Baik,
Yong-Hee Han
et al.
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54-56
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Autonomic involvement in Parkinson's disease: Pathology, pathophysiology, clinical features and possible peripheral biomarkers
17 October 2011
Abstract: Autonomic nervous system involvement occurs at early stages in both Parkinson's disease (PD) and incidental Lewy body disease (ILBD), and affects the sympathetic, parasympathetic, and enteri...
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Maria G. Cersosimo,
Eduardo E. Benarroch
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57-63
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Neurotrophin-3 gene modified mesenchymal stem cells promote remyelination and functional recovery in the demyelinated spinal cord of rats
14 October 2011
Abstract: Multiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by axonal/neuronal damage that may be caused by defective remyelination. Current therapies aim to slow the r...
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Yu-Jiao Zhang,
Wei Zhang,
Cheng-Guang Lin,
Ying Ding,
Si-Fan Huang,
Jin-Lang Wu,
Yan Li,
Hongxin Dong,
Yuan-Shan Zeng
et al.
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64-74
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Effect of the 50 bp deletion polymorphism in the SOD1 promoter on SOD1 mRNA levels in Italian ALS patients
18 October 2011
Abstract: The genetic association between homozygosity for a 50bp deletion polymorphism in the SOD1 promoter, 1684bp upstream of the ATG, and an increased age of symptom onset was observed in various ...
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P. Milani,
S. Gagliardi,
P. Bongioanni,
G.S. Grieco,
M. Dezza,
M. Bianchi,
E. Cova,
M. Ceroni,
C. Cereda
et al.
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75-78
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Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: A meta-analysis of case–control studies
28 October 2011
Abstract: Background: The vitamin D receptor (VDR) polymorphisms have been reported to be associated with multiple sclerosis (MS), however, evidence remains conflicting. A meta-analysis was conducted ...
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Jian Huang,
Zheng-Fu Xie
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79-85
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Trends in comorbid sickle cell disease among stroke patients
12 October 2011
Abstract: Background: Stroke is a major complication of sickle cell disease (SCD). In an era of chronic red cell transfusions for stroke prophylaxis in children and greater life expectancy, nationwide...
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Bruce Ovbiagele,
Robert J. Adams
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86-91
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Modifiable lifestyle behaviours account for most cases of subarachnoid haemorrhage: A population-based case–control study in Australasia
13 October 2011
Abstract: Background: Smoking, hypertension and alcohol excess are the major causal risk factors for subarachnoid haemorrhage (SAH) that are modifiable. We aimed to explore the hypothesis that other m...
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Ivy Shiue,
Hisatomi Arima,
Graeme J. Hankey,
Craig S. Anderson,
for the ACROSS Group
et al.
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92-94
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Objective home-based gait assessment in spinocerebellar ataxia
24 October 2011
Abstract: We investigated the utility of home-based gait monitor assessment in patients with spinocerebellar ataxia (SCA). Nineteen patients with different forms of SCA were examined using a step acti...
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S.H. Subramony,
S. Kedar,
E. Murray,
E. Protas,
H. Xu,
T. Ashizawa,
A. Tan
et al.
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95-98
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Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: Implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS
05 October 2011
Abstract: Multiple sclerosis (MS) is the most common immune-mediated disabling neurological disease of the central nervous system. The pathogenesis of MS is not fully understood. Histopathology implic...
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Khader M. Hasan,
Indika S. Walimuni,
Humaira Abid,
Sushmita Datta,
Jerry S. Wolinsky,
Ponnada A. Narayana
et al.
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99-109
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The factors associated with a functional outcome after ischemic stroke in diabetic patients: The Fukuoka Stroke Registry
12 October 2011
Abstract: Background: The prognosis in ischemic stroke is poor in diabetic patients. However, scant research has so far been done on the predisposing factors associated with poor outcomes. Methods: We...
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Takahiro Kuwashiro,
Masahiro Kamouchi,
Tetsuro Ago,
Jun Hata,
Hiroshi Sugimori,
Takanari Kitazono
et al.
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110-114
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Effects of highly active antiretroviral therapy on cognitive functions in severely immune-compromised HIV-seropositive patients
13 October 2011
Abstract: Objective: This study assessed the effects of highly active antiretroviral therapy on the cognitive performances of HIV seropositive patients with severe immune depression. Methods: It is a ...
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Yahaya O. Obiabo,
Olubunmi A. Ogunrin,
Abayomi S. Ogun
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115-122
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Cerebral oxygen metabolism in patients with early Parkinson's disease
05 October 2011
Abstract: Aim: Decreased activity of the mitochondrial electron transport chain (ETC) has been implicated in the pathogenesis of Parkinson's disease (PD). This model would most likely predict a decrea...
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Per Borghammer,
Paul Cumming,
Karen Østergaard,
Albert Gjedde,
Anders Rodell,
Christopher J. Bailey,
Manoucher S. Vafaee
et al.
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123-128
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New novel mutation of the ATP7B gene in a family with Wilson disease
10 November 2011
Abstract: Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The WD gene codes for a copper transporting P-type ATPase (ATP7B) are located on chromosome 13q14.3. Mutation of ...
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Jun-Young Lee,
Young-Hyun Kim,
Tae-Woo Kim,
Sun-Young Oh,
Dal-Sik Kim,
Byoung-Soo Shin
et al.
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129-131
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Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients — A preliminary study
04 October 2011
Abstract: Background and purpose: The aim of the present study was to investigate whether administration of edaravone during t-PA infusion can enhance early recanalization in acute stroke patients. Me...
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Kazumi Kimura,
Juya Aoki,
Yuki Sakamoto,
Kazuto Kobayashi,
Kenichi Sakai,
Takeshi Inoue,
Yasuyuki Iguchi,
Kensaku Shibazaki
et al.
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132-136
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Lack of association between vitamin D levels and bone mineral density in patients with multiple sclerosis
12 October 2011
Abstract: Background: There is conflicting evidence regarding the association of vitamin D status with bone mineral density (BMD) in adult patients with multiple sclerosis (MS). We evaluated cross-sec...
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Nikos Triantafyllou,
Irene Lambrinoudaki,
Penelope Thoda,
Elisabeth Andreadou,
Evangelia Kararizou,
Andreas Alexandrou,
George Limouris,
Aris Antoniou,
Georgios Tsivgoulis
et al.
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137-141
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Blood–brain barrier permeability derangements in posterior circulation ischemic stroke: Frequency and relation to hemorrhagic transformation
26 September 2011
Abstract: Background: Early disruption of the blood–brain barrier (BBB) due to severe ischemia can be detected by MRI T2* permeability imaging. In middle cerebral artery (MCA) infarction, pretreatment...
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Meng Lee,
Jeffrey L. Saver,
Jeffry R. Alger,
Qing Hao,
Sidney Starkman,
Latisha K. Ali,
Doojin Kim,
Bruce Ovbiagele,
Paul M. Vespa,
Michael T. Froehler,
Matthew S. Tenser,
Noriko Salamon,
J. Pablo Villablanca,
Reza Jahan,
Gary R. Duckwiler,
Satoshi Tateshima,
Nestor Gonzalez,
Fernando Vinuela,
David S. Liebeskind
et al.
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142-146
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Nationwide survey on the epidemiology of syringomyelia in Japan
26 September 2011
Abstract: Background: Syringomyelia is a rare disease characterized by abnormal fluid-filled cavities within the spinal cord, and is associated with Chiari malformations, arachnoiditis, or spinal cord...
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Ken Sakushima,
Satoshi Tsuboi,
Ichiro Yabe,
Kazutoshi Hida,
Satoshi Terae,
Ritei Uehara,
Imaharu Nakano,
Hidenao Sasaki
et al.
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147-152
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Audiovestibular loss in anterior inferior cerebellar artery territory infarction: A window to early detection?
14 October 2011
Abstract: Acute audiovestibular loss is a common neurotological condition that is characterized by sudden onset of severe prolonged (lasting days) vertigo and hearing loss and is diagnosed by the pres...
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Hyung Lee
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153-159
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Poor concurrence between disabilities as described by patients and established assessment tools three months after stroke: A mixed methods approach
21 September 2011
Abstract: Background: Disability/problems, one phenomenon underlying people's need for health care services, can be viewed both from the perspectives of people with stroke (felt problems), and the hea...
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Malin Tistad,
Charlotte Ytterberg,
Kerstin Tham,
Lena von Koch
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160-166
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Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis
03 October 2011
Abstract: Multiple sclerosis (MS) is associated with irreversible disability in a significant proportion of patients. At present, there is no treatment to halt or reverse the progression of establishe...
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Violaine K. Harris,
Qi Jiang Yan,
Tamara Vyshkina,
Sadia Sahabi,
Xinhe Liu,
Saud A. Sadiq
et al.
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167-177
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| Short Communications |
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Macrocephaly–capillary malformation syndrome: Three new cases
26 October 2011
Abstract: Overgrowth syndromes can be associated with asymmetry, obesity and various vascular malformations. Macrocephaly–Capillary Malformation (M–CM) is a more recently defined overgrowth syndrome c...
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Inusha Panigrahi,
Mani Bhushan,
Mukesh Yadav,
Niranjan Khandelwal,
Pratibha Singhi
et al.
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178-181
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‘Noteomielite’ accompanied by acute amaurosis (1844). An early case of neuromyelitis optica
13 October 2011
Abstract: So far, only very little is known about the early history of neuromyelitis optica (Devic's syndrome). Here, we discuss a then widely recognized but now forgotten 1844 report by the Genoese p...
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S. Jarius,
B. Wildemann
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182-184
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POEMS syndrome with prominent acute axonal lesions
07 October 2011
Abstract: Polyneuropathy is a common presenting component of POEMS syndrome whose symptoms are attributed to an overproduction of vascular endothelial growth factor (VEGF). We report two female patien...
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S. Mathis,
L. Magy,
R. Kaboré,
F. Faugeras,
L. Richard,
J.-M. Vallat
et al.
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185-188
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A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea
07 October 2011
Abstract: A Japanese family with a novel nonsense mutation in the TITF-1 gene (p.Y98X) is described. The proband showed severe generalized chorea, delayed motor development, subnormal intelligence, co...
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Katsuya Nakamura,
Yoshiki Sekijima,
Kiyoshiro Nagamatsu,
Kunihiro Yoshida,
Shu-ichi Ikeda
et al.
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189-192
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Reactivation of type 1 herpes simplex virus and varicella zoster virus in an immunosuppressed patient with acute peripheral facial weakness
19 September 2011
Abstract: We describe a 26-year-old man treated with azathioprine for myasthenia gravis who developed acute left-sided peripheral facial weakness. Brain magnetic resonance imaging (MRI) revealed enhan...
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Jean Tsai,
Randall J. Cohrs,
Maria A. Nagel,
Ravi Mahalingam,
D. Scott Schmid,
Alexander Choe,
Don Gilden
et al.
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193-195
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| Letter to the Editor |
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Multiple biomarkers for oxidative stress in patients with brain disorders
07 November 2011
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Hirokazu Tsukahara,
Yosuke Fujii,
Yuko Hayashi,
Tsuneo Morishima
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196
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| Book Reviews |
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Book review
19 October 2011
The clinical and research applications and utilization of diffusion MRI have expanded rapidly over the last few years. In the current scenario, this book is an indispensible addition to the growing sc...
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Pratik D. Bhattacharya
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197
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Why people get lost: the psychology and neuroscience of spatial cognition, Paul A. Dudchenko, Oxford University Press, pages, $54.95, ISBN: 978-0-19-921086-2; 299
24 October 2011
Who hasn't felt one or more of these symptoms? Getting lost is a universal experience, writes University of Stirling lecturer Paul A. Dudchenko in the first chapter of his book, unambiguously titled W...
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Ilana R. Yurkiewicz,
Jack W. Tsao
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197-198
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Book review
19 October 2011
Judge a book by its cover, and Oxford Care Manuals look very similar: the series of medical guides are all conveniently pocket-sized and publicize themselves as targeting a readership of health profes...
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Ilana R. Yurkiewicz,
Jack W. Tsao
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198
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Book review
19 October 2011
Brains: How They Seem to Work, written by Dr. Dale Purves, a professor of Neurobiology, Psychology, Neuroscience, and Philosophy at Duke University, provides not only information concerning how the br...
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Brett T. Monson,
Jack W. Tsao
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199
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Book review
20 October 2011
Evidence Based Medicine is defined as the explicit and judicious use of current best evidence in making decisions about care of individual patients. (Sackett et al. BMJ 1996, 312:76). If we have to of...
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Kumar Rajamani
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199
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Calendar of Events
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