Journal of the Neurological Sciences
Volume 298, Issue 1 , Pages 91-95 , 15 November 2010

Deficits in stepping response time are associated with impairments in balance and mobility in people with Huntington disease

  • Allon Goldberg

      Affiliations

    • Department of Health Care Sciences, Program in Physical Therapy, Mobility Research Laboratory, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA
    • Institute of Gerontology, Wayne State University, 87 East Ferry St., Detroit, MI 48202, USA
    • Department of Internal Medicine, School of Medicine, Wayne State University, 3800 Woodward Ave., Detroit, MI 48201, USA
    • Corresponding Author InformationCorresponding author. Department of Health Care Sciences, Program in Physical Therapy, Mobility Research Laboratory, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA. Tel.: +1 313 577 8608; fax: +1 313 577 8685.
    • ,
  • Stacey L. Schepens

      Affiliations

    • Department of Health Care Sciences, Program in Physical Therapy, Mobility Research Laboratory, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA
    • Institute of Gerontology, Wayne State University, 87 East Ferry St., Detroit, MI 48202, USA
    • Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.
    • ,
  • Shawna M.E. Feely

      Affiliations

    • Department of Neurology and Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, 421 E. Canfield Rd, Detroit, MI 48201, USA
    • ,
  • James Y. Garbern

      Affiliations

    • Department of Neurology and Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, 421 E. Canfield Rd, Detroit, MI 48201, USA
    • ,
  • Lindsey J. Miller

      Affiliations

    • Department of Neurology and Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, 421 E. Canfield Rd, Detroit, MI 48201, USA
    • ,
  • Carly E. Siskind

      Affiliations

    • Department of Neurology and Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, 421 E. Canfield Rd, Detroit, MI 48201, USA
    • ,
  • Gerry E. Conti

      Affiliations

    • Department of Health Care Sciences, Program in Occupational Therapy, Human Movement Laboratory, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA

Received 2 June 2010 ,Revised 29 July 2010 ,Accepted 5 August 2010.

References 

  1. Mahant N, McCusker EA, Byth K, Graham S. Huntington's disease: clinical correlates of disability and progression. Neurology. 2003;61:1085–1092
  2. Thompson PD, Berardelli A, Rothwell JC, Day BL, Dick JP, Benecke R, et al. The coexistence of bradykinesia and chorea in Huntington's disease and its implications for theories of basal ganglia control of movement. Brain. 1988;111(Pt 2):223–244
  3. Garcia Ruiz PJ, Hernandez J, Cantarero S, Bartolome M, Sanchez Bernardos V, Garcia de Yebenez J. Bradykinesia in Huntington's disease. A prospective, follow-up study. J Neurol. 2002;249:437–440
  4. Beglinger LJ, Duff K, Allison J, Theriault D, O'Rourke JJ, Leserman A, et al. Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status. J Clin Exp Neuropsychol. 2009;1–6
  5. Anderson KE, Gehl CR, Marder KS, Beglinger LJ, Paulsen JS. Comorbidities of obsessive and compulsive symptoms in Huntington's disease. J Nerv Ment Dis. 2010;198:334–338
  6. Rao AK, Muratori L, Louis ED, Moskowitz CB, Marder KS. Clinical measurement of mobility and balance impairments in Huntington's disease: validity and responsiveness. Gait Posture. 2009;29:433–436
  7. Rao AK, Muratori L, Louis ED, Moskowitz CB, Marder KS. Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease. Mov Disord. 2008;23:1100–1107
  8. Grimbergen YA, Knol MJ, Bloem BR, Kremer BP, Roos RA, Munneke M. Falls and gait disturbances in Huntington's disease. Mov Disord. 2008;23:970–976
  9. Busse ME, Wiles CM, Rosser AE. Mobility and falls in people with Huntington's disease. J Neurol Neurosurg Psychiatry. 2009;80:88–90
  10. Wheelock VL, Tempkin T, Marder K, Nance M, Myers RH, Zhao H, et al. Predictors of nursing home placement in Huntington disease. Neurology. 2003;60:998–1001
  11. Berg KO, Wood-Dauphinee SL, Williams JI, Maki B. Measuring balance in the elderly: validation of an instrument. Can J Public Health. 1992;83(Suppl 2):S7–S11
  12. Podsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39:142–148
  13. Horak FB, Nashner LM. Central programming of postural movements: adaptation to altered support-surface configurations. J Neurophysiol. 1986;55:1369–1381
  14. McIlroy WE, Maki BE. Age-related changes in compensatory stepping in response to unpredictable perturbations. J Gerontol A Biol Sci Med Sci. 1996;51:M289–M296
  15. Thelen DG, Wojcik LA, Schultz AB, Ashton-Miller JA, Alexander NB. Age differences in using a rapid step to regain balance during a forward fall. J Gerontol A Biol Sci Med Sci. 1997;52:M8–M13
  16. Lord SR, Fitzpatrick RC. Choice stepping reaction time: a composite measure of falls risk in older people. J Gerontol A Biol Sci Med Sci. 2001;56:M627–M632
  17. Medell JL, Alexander NB. A clinical measure of maximal and rapid stepping in older women. J Gerontol A Biol Sci Med Sci. 2000;55:M429–M433
  18. Rao AK, Louis ED, Marder KS. Clinical assessment of mobility and balance impairments in pre-symptomatic Huntington's disease. Gait Posture. 2009;30:391–393
  19. Powell LE, Myers AM. The Activities-specific Balance Confidence (ABC) Scale. J Gerontol A Biol Sci Med Sci. 1995;50A:M28–M34
  20. Duncan PW, Weiner DK, Chandler J, Studenski S. Functional reach: a new clinical measure of balance. J Gerontol. 1990;45:M192–M197
  21. Huntington Study Group . Unified Huntington's Disease Rating Scale: reliability and consistency. Mov Disord. 1996;11:136–142
  22. Haley SM, Fragala-Pinkham MA. Interpreting change scores of tests and measures used in physical therapy. Phys Ther. 2006;86:735–743
  23. Hollman JH, Beckman BA, Brandt RA, Merriwether EN, Williams RT, Nordrum JT. Minimum detectable change in gait velocity during acute rehabilitation following hip fracture. J Geriatr Phys Ther. 2008;31:53–56
  24. Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychol Bull. 1979;86:420–428
  25. Stratford PW. Getting more from the literature: estimating the standard error of measurement from reliability studies. Physiother Can. 2004;56:27–30
  26. Portney LG, Watkins MP. Foundations of clinical research: applications to practice. In: 3rd ed. Upper Saddle River, NJ: Prentice-Hall, Inc; 2009;
  27. Duyao M, Ambrose C, Myers R, Novelletto A, Persichetti F, Frontali M, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet. 1993;4:387–392
  28. Garnett ES, Firnau G, Nahmias C, Carbotte R, Bartolucci G. Reduced striatal glucose consumption and prolonged reaction time are early features in Huntington's disease. J Neurol Sci. 1984;65:231–237
  29. Delval A, Krystkowiak P, Blatt JL, Labyt E, Bourriez JL, Dujardin K, et al. A biomechanical study of gait initiation in Huntington's disease. Gait Posture. 2007;25:279–288

PII: S0022-510X(10)00351-5

doi: 10.1016/j.jns.2010.08.002

Journal of the Neurological Sciences
Volume 298, Issue 1 , Pages 91-95 , 15 November 2010

Article Tools

* Image Usage & Resolution