Journal of the Neurological Sciences
Volume 296, Issue 1 , Pages 13-21 , 15 September 2010

Difference of fibroblast growth factor receptor 1 expression among CA1-3 regions of the gerbil hippocampus after transient cerebral ischemia

  • Ki-Yeon Yoo

      Affiliations

    • Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea
    • ,
  • In Koo Hwang

      Affiliations

    • Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea
    • ,
  • Choong Hyun Lee

      Affiliations

    • Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea
    • ,
  • Jung Hoon Choi

      Affiliations

    • Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea
    • ,
  • Seung-Hae Kwon

      Affiliations

    • Division of Analytical Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, 200-701, Republic of Korea
    • ,
  • Il-Jun Kang

      Affiliations

    • Department of Food Science and Nutrition, Hallym University, Chuncheon 200-702, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Won is to be contacted at the Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea. Tel.: +82 33 248 2522; fax: +82 33 256 1614. Kang, Tel.: +82 33 248 2135; fax: +82 33 255 4787.
    • ,
  • Sang Guan You

      Affiliations

    • Marine Food Science and Technology, Kangnung-Wonju National University, Gangneung 210-702, Republic of Korea
    • ,
  • Young-Myeong Kim

      Affiliations

    • Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, 200-701, Republic of Korea
    • ,
  • Moo-Ho Won

      Affiliations

    • Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Won is to be contacted at the Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea. Tel.: +82 33 248 2522; fax: +82 33 256 1614. Kang, Tel.: +82 33 248 2135; fax: +82 33 255 4787.

Received 11 January 2010 ,Revised 16 June 2010 ,Accepted 17 June 2010.

References 

  1. Kristian T, Siesjo BK. Calcium in ischemic cell death. Stroke. 1998;29:705–718
  2. Wu JB, Song NN, Wei XB, Guan HS, Zhang XM. Protective effects of paeonol on cultured rat hippocampal neurons against oxygen–glucose deprivation-induced injury. J Neurol Sci. 2008;264:50–55
  3. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 1982;239:57–69
  4. Szilagyi G, Simon L, Wappler E, Magyar K, Nagy Z. (-)Deprenyl-N-oxide, a (-)deprenyl metabolite, is cytoprotective after hypoxic injury in PC12 cells, or after transient brain ischemia in gerbils. J Neurol Sci. 2009;283:182–186
  5. Andersen MB, Sams-Dodd F. Impairment of working memory in the T-maze after transient global cerebral ischemia in the Mongolian gerbil. Behav Brain Res. 1998;91:15–22
  6. Mayevsky A, Sclarksy DL. Correlation of brain NADH redox state, K+, PO2 and electrical activity during hypoxia, ischemia and spreading depression. Adv Exp Med Biol. 1983;159:129–141
  7. Olson EE, McKeon RJ. Characterization of cellular and neurological damage following unilateral hypoxia/ischemia. J Neurol Sci. 2004;227:7–19
  8. Provinciali L, Coccia M. Post-stroke and vascular depression: a critical review. Neurol Sci. 2002;22:417–428
  9. Schwartz C, Wishart TB, Ijaz S, Shuaib A. Aging and ischemia in gerbils impair spatial memory performance. Behav Neurosci. 1998;112:937–941
  10. Eckenstein FP. Fibroblast growth factors in the nervous system. J Neurobiol. 1994;25:1467–1480
  11. Ward GR, Franklin SO, Gerald TM, Dempsey KT, Clodfelter DE, Krissinger DJ, et al. Glucocorticoids plus opioids up-regulate genes that influence neuronal function. Cell Mol Neurobiol. 2007;27:651–660
  12. Reuss B, von Bohlen und Halbach O. Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res. 2003;313:139–157
  13. Abe K, Saito H. Effects of basic fibroblast growth factor on central nervous system functions. Pharmacol Res. 2001;43:307–312
  14. Di Serio C, Cozzi A, Angeli I, Doria L, Micucci I, Pellerito S, et al. Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro. Cell Mol Neurobiol. 2005;25:981–993
  15. Bugra K, Pollard H, Charton G, Moreau J, Ben-Ari Y, Khrestchatisky M. aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures. Eur J Neurosci. 1994;6:58–66
  16. Gaughran F, Payne J, Sedgwick PM, Cotter D, Berry M. Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Brain Res Bull. 2006;70:221–227
  17. Gomez-Pinilla F, Cotman CW. Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex. Neuroscience. 1992;49:771–780
  18. Reilly JF, Kumari VG. Alterations in fibroblast growth factor receptor expression following brain injury. Exp Neurol. 1996;140:139–150
  19. Takami K, Kiyota Y, Iwane M, Miyamoto M, Tsukuda R, Igarashi K, et al. Upregulation of fibroblast growth factor-receptor messenger RNA expression in rat brain following transient forebrain ischemia. Exp Brain Res. 1993;97:185–194
  20. Wei OY, Huang YL, Da CD, Cheng JS. Alteration of basic fibroblast growth factor expression in rat during cerebral ischemia. Acta Pharmacol Sin. 2000;21:296–300
  21. Mudo G, Bonomo A, Di Liberto V, Frinchi M, Fuxe K, Belluardo N. The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain. J Neural Transm. 2009;116:995–1005
  22. Loskota WA, Lomax P, Verity MA. A stereotaxic atlas of the Mongolian Gerbil Brain (Meriones unguiculatus). Michigan: Ann Arbor Science Publishers Inc; 1974;
  23. Hwang IK, Hua L, Yoo KY, Kim DW, Kang TC, Choi SY, et al. Antioxidant-like protein 1 is altered in non-pyramidal cells and expressed in astrocytes in the gerbil hippocampal CA1 region after transient forebrain ischemia. Brain Res. 2005;1062:111–119
  24. Hwang IK, Yoo KY, Kim DS, Eum WS, Park JK, Park J, et al. Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia. Neuroscience. 2004;128:511–518
  25. Hwang IK, Yoo KY, Kim DW, Kang TC, Choi SY, Kwon YG, et al. Na+/Ca2+ exchanger 1 alters in pyramidal cells and expresses in astrocytes of the gerbil hippocampal CA1 region after ischemia. Brain Res. 2006;1086:181–190
  26. Hwang IK, Yoo KY, Suh HW, Kim YS, Kwon DY, Kwon YG, et al. Folic acid deficiency increases delayed neuronal death, DNA damage, platelet endothelial cell adhesion molecule-1 immunoreactivity, and gliosis in the hippocampus after transient cerebral ischemia. J Neurosci Res. 2008;86:2003–2015
  27. Logan A, Frautschy SA, Gonzalez AM, Baird A. A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. J Neurosci. 1992;12:3828–3837
  28. Li S, Christensen C, Kohler LB, Kiselyov VV, Berezin V, Bock E. Agonists of fibroblast growth factor receptor induce neurite outgrowth and survival of cerebellar granule neurons. Dev Neurobiol. 2009;69:837–854
  29. Liu X, Zhu XZ. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults. Brain Res Mol Brain Res. 1999;71:171–177
  30. Reuss B, Dono R, Unsicker K. Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood–brain barrier permeability: evidence from mouse mutants. J Neurosci. 2003;23:6404–6412
  31. Eckenstein FP, McGovern T, Kern D, Deignan J. Neuronal vulnerability in transgenic mice expressing an inducible dominant-negative FGF receptor. Exp Neurol. 2006;198:338–349
  32. Masumura M, Murayama N, Inoue T, Ohno T. Selective induction of fibroblast growth factor receptor-1 mRNA after transient focal ischemia in the cerebral cortex of rats. Neurosci Lett. 1996;213:119–122

PII: S0022-510X(10)00288-1

doi: 10.1016/j.jns.2010.06.018

Journal of the Neurological Sciences
Volume 296, Issue 1 , Pages 13-21 , 15 September 2010

Article Tools

* Image Usage & Resolution