Journal of the Neurological Sciences
Volume 292, Issue 1 , Pages 114-116, 15 May 2010

Guillain-Barré Syndrome as leading manifestation of Graft-versus-Host Disease in an allogeneic bone marrow transplanted patient

Department of Neurology, Clinical Center Nuernberg South, Breslauerstr. 201, 90471 Nuernberg, Germany

Received 29 September 2009; received in revised form 13 January 2010; accepted 21 January 2010. published online 17 February 2010.

Abstract 

Guillain-Barré Syndrome (GBS) is the most frequent cause of neuromuscular paralysis in industrialized countries and usually occurs after respiratory and gastrointestinal infections. However, in rare cases GBS is associated with Graft-versus-Host Disease (GvHD). In the present case we report on a female allogeneic bone marrow transplanted patient who developed GBS as a leading manifestation of GvHD subsequent to discontinuation of her immunosuppressive medication with cyclosporine. In contrast to former case reports both IVIg and plasma exchange failed while resumption of immunosuppressive medication improved the condition of the patient clearly.

Keywords: GvHD, GBS, Cyclosporine, AlloBMT, Transplantation, IVIg, Plasma exchange

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0022-510X(10)00047-X

doi:10.1016/j.jns.2010.01.020

Journal of the Neurological Sciences
Volume 292, Issue 1 , Pages 114-116, 15 May 2010

Article Tools