Journal of the Neurological Sciences
Volume 291, Issue 1 , Pages 44-51 , 15 April 2010

Spectrum of epilepsy in Wilson's disease with electroencephalographic, MR imaging and pathological correlates

  • L.K. Prashanth

      Affiliations

    • Department of Neurology, NIMHANS, Bangalore, India
  • ,
  • S. Sinha

      Affiliations

    • Department of Neurology, NIMHANS, Bangalore, India
    • Corresponding Author InformationCorresponding author. NIMHANS, Hosur Road, Bangalore: 560029, India. Tel.: +91 802 699 5150; fax: +91 802 656 4830.
  • ,
  • A.B. Taly

      Affiliations

    • Department of Neurology, NIMHANS, Bangalore, India
  • ,
  • A.Mahadevan

      Affiliations

    • Department of Neuropathology, NIMHANS, Bangalore, India
  • ,
  • M.K. Vasudev

      Affiliations

    • Department of Neuroimaging and Interventional Neuroradiology, NIMHANS, Bangalore, India
  • ,
  • S.K. Shankar

      Affiliations

    • Department of Neuropathology, NIMHANS, Bangalore, India

Received 20 November 2009 ,Revised 30 December 2009 ,Accepted 7 January 2010.

References 

  1. Compston A. Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver, by S. A. Kinnier Wilson, (From the National Hospital, and the Laboratory of the National Hospital, Queen Square, London). Brain. 1912;34:295–509Brain. 2009;132(8):1997–2001
  2. Brewer GJ. Wilson's disease: a clinician's guide to recognition, diagnosis and management. Norwel, MA: Kluwer Academic Publishers; 2001;
  3. Hoogenraad T. Clinical manifesatations. In:  Hoogenraad T editors. Wilson's disease. London: WB Saunders; 1996;p. 71–108
  4. Taly AB, Meenakshi-Sundaram S, Sinha S, Swamy HS, Arunodaya GR. Wilson disease: description of 282 patients evaluated over 3 decades. Medicine. 2007;82:112–121
  5. Machado A, Chien HF, Deguti MM, Cançado E, Azevedo RS, Scaff M, et al. Neurological manifestations in Wilson's disease: report of 119 cases. Mov Disord. 2006;21:2192–2196
  6. Strickland GT, Frommer D, Leu ML, Pollard R, Sherlock S, Cumings JN. Wilson's disease in the United Kingdom and Taiwan. Q J Med. 1973;42:619–638
  7. Marsden CD. Wilson's disease. Q J Med. 1987;65:959–966
  8. Saito T. Presenting symptoms and natural history of Wilson's disease. Eur J Pediatr. 1987;146:261–265
  9. Lau JYN, Lai CL, Wu PC, Pan HYM, Lin HJ, Todd D. Wilson's disease: 35years experience. Q J Med. 1990;75:597–605
  10. Brewer GJ, Yuzbasiyan-Gurkan V. Wilson disease. Medicine. 1992;71:139–164
  11. Dening TR, Berrios GE, Walshe JM. Wilson's disease and epilepsy. Brain. 1988;111:1139–1155
  12. Prashanth LK, Taly AB, Sinha S, Arunodaya GR, Swamy HS. Wilson's disease: diagnostic errors and clinical implications. J Neurol Neurosurg Psychiatry. 2004;75(6):907–909
  13. Yoshida K, Maruyama K, Hashimoto T, Shindo M, Shoji S, Yanagisawa N. A case of Wilson's disease who developed status epilepticus during D-penicillamine therapy. Nippon Naika Gakkai Zasshi. 1989;78:70–74
  14. Türk-Börü U, Kocer A, Alp R, Gümüş M, Gümüş M. Status epilepticus in a case with Wilson's disease during D-pencillamine treatment. Swiss Med Wkly. 2003;133:446–447
  15. Kumar S. Wilson's disease presenting as status epilepticus. Indian Pediatr. 2005;42:492–493
  16. Shukla R, Desai P, Vinod P. Wilson's disease presenting as status epilepticus. J Assoc Physicians India. 2006;54:887–889
  17. Pestana Knight EM, Gilman S, Selwa L. Status epilepticus in Wilson's disease. Epileptic Disord. 2009;11(2):138–143
  18. Satishchandra P. Hot water epilepsy. Epilepsia. 2003;44(suppl 1):29–32
  19. Saka E, Elibol B, Saygi S. Circling seizures in a case with Wilson's disease. Clin Electroencephalogr. 1999;30:118–1121
  20. Streifler M, Feldman S. Effect of dimercaprol (BAL) in hepatolenticular degeneration: report of a case, with clinical and electroencephalographic study. Arch Neurol Psychiatr. 1953;69:84–90
  21. Sinha S, Taly AB, Ravishankar S, Prashanth LK, Venugopal KS, Arunodaya GR, et al. Wilson's disease: cranial MRI observations and clinical correlation. Neuroradiology. 2006;48(9):613–621
  22. Huang CC, Chu NS. Psychosis and epileptic seizures in Wilson's disease with predominantly white matter lesions in the frontal lobe. Parkinsonism Relat Disord. 1995;1:53–58
  23. Meenakshi-Sundaram S, Mahadevan A, Taly AB, Arunodaya GR, Swamy HS, Shankar SK. Wilson's disease: a clinico-neuropathological autopsy study. J Clin Neurosci. 2008;15:409–417
  24. Smith CK, Mattson RH. Seizures in Wilson's disease. Neurology. 1967;17:1121–1123
  25. Peters RA, Shorthouse M, Walshe JM. The effect of Cu2+ on the membrane ATPase and its relation to the initiation of convulsions. J Physiol. 1965;181:27–28
  26. Walshe JM. Copper and the brain. In:  Rose FC editors. Metabolic disorders of the nervous system. London: Pitman; 1981;p. 352–358
  27. Follesa P, Mallei A, Floris S, Mostallino MC, Sanna E, Biggio G. Increased abundance of GABAA receptor subunit mRNAs in the brain of Long–Evans Cinnamon rats, an animal model of Wilson's disease. Brain Res Mol Brain Res. 1999;63:268–275

PII: S0022-510X(10)00015-8

doi: 10.1016/j.jns.2010.01.007

Journal of the Neurological Sciences
Volume 291, Issue 1 , Pages 44-51 , 15 April 2010