Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 12-15 , 15 March 2010

Asymmetric dimethylarginine (ADMA) as a possible risk marker for ischemic stroke

  • Yasuhiro Nishiyama

      Affiliations

    • Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    • Corresponding Author InformationCorresponding author. Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. Tel.: +81 3 3822 2131x6496; fax: +81 3 3822 4865.
    • ,
  • Masayuki Ueda

      Affiliations

    • Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    • ,
  • Ken-ichiro Katsura

      Affiliations

    • Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    • ,
  • Toshiaki Otsuka

      Affiliations

    • Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    • ,
  • Arata Abe

      Affiliations

    • Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    • Stroke Center, Shioda Hospital, Chiba, Japan
    • ,
  • Hiroshi Nagayama

      Affiliations

    • Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    • ,
  • Yasuo Katayama

      Affiliations

    • Divisions of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan

Received 15 September 2009 ,Revised 15 December 2009 ,Accepted 18 December 2009.

References 

  1. Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol. 2006;147(Suppl 1):S193–S201
  2. Napoli C, Ignarro LJ. Nitric oxide and atherosclerosis. Nitric Oxide. 2001;5:88–97
  3. Kerkeni M, Letaief A, Achour A, Miled A, Trivin F, Maaroufi K. Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease. Clin Biochem. 2009;42:958–964
  4. Sedoris KC, Ovechkin AV, Gozal E, Roberts AM. Differential effects of nitric oxide synthesis on pulmonary vascular function during lung ischemia–reperfusion injury. Arch Physiol Biochem. 2009;115:34–46
  5. Mookerjee RP, Malaki M, Davies NA, Hodges SJ, Dalton RN, Turner C, et al. Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis. Hepatology. 2007;45:62–71
  6. Vallance P, Leone A, Calver A, Collier J, Moncada S. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol. 1992;20(Suppl 12):S60–S62
  7. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 1992;339:572–575
  8. Surdacki A. L-arginine analogs—inactive markers or active agents in atherogenesis?. Cardiovasc Hematol Agents Med Chem. 2008;6:302–311
  9. Schnabel R, Blankenberg S, Lubos E, Lackner KJ, Rupprecht HJ, Espinola-Klein C, et al. Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study. Circ Res. 2005;97:e53–e59
  10. Matsuoka H, Itoh S, Kimoto M, Kohno K, Tamai O, Wada Y, et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension. 1997;29:242–247
  11. Lu TM, Ding YA, Leu HB, Yin WH, Sheu WH, Chu KM. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol. 2004;94:157–161
  12. Pasini AF, Garbin U, Stranieri C, Boccioletti V, Mozzini C, Manfro S, et al. Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients. Am J Hypertens. 2008;21:1251–1257
  13. Alfieri AB, Briceno L, Fragasso G, Spoladore R, Palloshi A, Bassanelli G, et al. Differential long-term effects of carvedilol on proinflammatory and antiinflammatory cytokines, asymmetric dimethylarginine, and left ventricular function in patients with heart failure. J Cardiovasc Pharmacol. 2008;52:49–54
  14. Scalera F, Martens-Lobenhoffer J, Bukowska A, Lendeckel U, Täger M, Bode-Böger SM. Effect of telmisartan on nitric oxide–asymmetrical dimethylarginine system: role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endothelial aging. Hypertension. 2008;51:696–703

PII: S0022-510X(09)01023-5

doi: 10.1016/j.jns.2009.12.020

Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 12-15 , 15 March 2010

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