Journal of the Neurological Sciences
Volume 291, Issue 1 , Pages 74-78 , 15 April 2010

Antineuronal autoantibodies in paraneoplastic cerebellar degeneration associated with adenocarcinoma of the prostate

  • John E. Greenlee

      Affiliations

    • Neurology Service, George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA
    • Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA
    • Brain Institute, University of Utah School of Medicine, Salt Lake City, UT, USA
    • Corresponding Author InformationCorresponding author. Neurology Service (127) Veterans Affairs Medical Center, 500 Foothill Drive, Salt Lake City, UT 84148, USA. Tel.: +1 801 584 1218; fax: +1 801 582 6908.
    • ,
  • Susan A. Clawson

      Affiliations

    • Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA
    • ,
  • Kenneth E. Hill

      Affiliations

    • Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA
    • ,
  • Christopher B. Dechet

      Affiliations

    • Division of Urology, University of Utah School of Medicine, Salt Lake City, UT, USA
    • Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA
    • ,
  • Noel G. Carlson

      Affiliations

    • GRECC, George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA
    • Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA
    • Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT, USA
    • Brain Institute, University of Utah School of Medicine, Salt Lake City, UT, USA

Received 3 October 2009 ,Revised 11 December 2009 ,Accepted 18 December 2009.

References 

  1. Shams'ili S, Grefkens J, De Leeuw B, van den BM, Hooijkaas H, van der HB, et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain. 2003;126:1409–1418
  2. Greenlee JE, Boyden JW, Pingree M, Brashear HR, Clawson SA, Keeney PM. Antibody types and IgG subclasses in paraneoplastic neurological syndromes. J Neurol Sci. 2001;184:131–137
  3. Hill KE, Clawson SA, Rose JW, Carlson NG, Greenlee JE. Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeutics. J Neuroinflammation. 2009;6:31
  4. Cattoretti G, Pileri S, Parravicini C, Becker MH, Poggi S, Bifulco C, et al. Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections. J Pathol. 1993;171:83–98
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  6. Sakai K, Mitchell DJ, Tsukamoto T, Steinman L. Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration. Ann Neurol. 1990;28:692–698
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  8. Lucchinetti CF, Kimmel DW, Lennon VA. Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies. Neurology. 1998;50:652–657
  9. Stern RC, Hulette CM. Paraneoplastic limbic encephalitis associated with small cell carcinoma of the prostate. Mod Pathol. 1999;12:814–818
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  12. Leyhe T, Schule R, Schwarzler F, Gasser T, Haarmeier T. Second primary tumor in anti-Ma1/2-positive paraneoplastic limbic encephalitis. J Neurooncol. 2006;78:49–51
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  14. McLoughlin J, Gingell JC, Harper G, Hinchliffe A. Cerebellar manifestations of prostatic carcinoma. Postgrad Med J. 1992;68:584–586
  15. Modrego PJ, Cay A, Pina MA, Monge A. Paraneoplastic subacute encephalitis caused by adenocarcinoma of prostate: a clinico-pathological case report. Acta Neurol Scand. 2002;105:351–353
  16. Dalmau J, Rosenfeld MR. Paraneoplastic syndromes of the CNS. Lancet Neurol. 2008;7:327–340
  17. Graus F, Illa I, Agusta M, Ribalta T, Cruz-Sanchez F, Juarez C. Effect of intraventricular injection of anti-Purkinje cell antibody (anti-Yo) in a guinea pig model. J Neurol Sci. 1991;106:82–87
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PII: S0022-510X(09)01022-3

doi: 10.1016/j.jns.2009.12.019

Journal of the Neurological Sciences
Volume 291, Issue 1 , Pages 74-78 , 15 April 2010

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