Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 131-134 , 15 March 2010

Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy

  • Nikos Triantafyllou

      Affiliations

    • Department of Neurology, University of Athens, Eginition Hospital, Athens, Greece
    • ,
  • Irini Lambrinoudaki

      Affiliations

    • Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Athens, Greece
    • ,
  • Elena Armeni

      Affiliations

    • Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Athens, Greece
    • ,
  • Eleftheria-Maria Evangelopoulos

      Affiliations

    • Department of Neurology, University of Athens, Eginition Hospital, Athens, Greece
    • ,
  • Fotini Boufidou

      Affiliations

    • Department of Neurology, University of Athens, Eginition Hospital, Athens, Greece
    • ,
  • Aris Antoniou

      Affiliations

    • Department of Nuclear Medicine, University of Athens, Areteion Hospital, Athens, Greece
    • ,
  • Georgios Tsivgoulis

      Affiliations

    • Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    • Corresponding Author InformationCorresponding author. Kapodistriou 3, Nea Xili, Alexandroupolis 68100, Greece. Tel.: +30 6937178635; fax: +30 2551030479.

Received 10 September 2009 ,Revised 5 November 2009 ,Accepted 16 December 2009.

References 

  1. Valsamis HA, Arora SK, Labban B, McFarlane SI. Antiepileptic drugs and bone metabolism. Nutr Metab. 2006;3:36
  2. Pack A. Bone health in people with epilepsy: is it impaired and what are the risk factors?. Seizure. 2008;17:181–186
  3. Anderson GD. Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs. Neurology. 2004;63:S3–S8
  4. Heller AJ, Chestermen P, Elwes RDC, et al. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomized comparative monotherapy trial. J Neurol Neurosurg Psychiatry. 1995;58:44–50
  5. Sheth RD, Wesolowski CA, Jacob JC, et al. Effect of carbamazepine and valproate on bone mineral density. J Pediatr. 1995;127:256–262
  6. Akin R, Okutan V, Sarici Ü, et al. Evaluation of bone mineral density in children receiving antiepileptic drugs. Pediatr Neurol. 1998;19:129–131
  7. Pavlakis SG, Chusid RC, Roye DP, et al. Valproate therapy: predisposition to bone fracture?. Pediatr Neurol. 1998;19:143–144
  8. Kafali G, Erselcan T, Tanzer F. Effect of antiepileptic drugs on bone mineral density in children between ages 6 and 12years. Clin Pediatr. 1999;38:93–98
  9. Sato Y, Kondo I, Ishida S, et al. Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology. 2001;57:445–449
  10. Farhat G, Yamout B, Mikati MA, et al. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology. 2002;58:1348–1353
  11. Boluk A, Guzelipek M, Savli H, Temel I, Ozişik HI, Kaygusuz A. The effect of valproate on bone mineral density in adult epileptic patients. Pharmacol Res. 2004;50:93–97
  12. Pack AM, Morrell MJ, Randall A, McMahon DJ, Shane E. Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. Neurology. 2008;70:1586–1593
  13. Kim SH, Lee JW, Choi KG, Chung HW, Lee HW. A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy. Epilepsy Behav. 2007;10:291–295
  14. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137–1141
  15. Lukert BP, Raisz LG. Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med. 1990;112:352–364
  16. Pack AM, Morrell MJ, Marcus R, et al. Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol. 2005;57:252–257
  17. Davie MW, Emberson CE, Lawson DE, et al. Low plasma 25-hydroxyvitamin D and serum calcium levels in institutionalized epileptic subjects: associated risk factors, consequences and response to treatment with vitamin D. Q J Med. 1983;52:79–91
  18. Gough H, Goggin T, Bissessar A, Baker M, Crowley M, Callaghan N. A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy. Q J Med. 1986;59:569–577
  19. Stephen LJ, McLellan AR, Harrison JH, et al. Bone density and antiepileptic drugs: a case-controlled study. Seizure. 1999;8:339–342

PII: S0022-510X(09)01006-5

doi: 10.1016/j.jns.2009.12.015

Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 131-134 , 15 March 2010

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