Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 41-47 , 15 March 2010

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS

  • Farhad Ghoddoussi

      Affiliations

    • Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • Department of Anesthesiology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • ,
  • Matthew P. Galloway

      Affiliations

    • Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • Department of Anesthesiology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • ,
  • Amruta Jambekar

      Affiliations

    • Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • ,
  • Monica Bame

      Affiliations

    • Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • ,
  • Richard Needleman

      Affiliations

    • Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • ,
  • William S.A. Brusilow

      Affiliations

    • Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 313 577 6659; fax: +1 313 577 2765.

Received 29 June 2009 ,Revised 24 November 2009 ,Accepted 24 November 2009.

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PII: S0022-510X(09)00976-9

doi: 10.1016/j.jns.2009.11.013

Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 41-47 , 15 March 2010

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