A study of α1 antichymotrypsin gene polymorphism in Indian stroke patients

Abstract 

Objective

To evaluate the role of ACT gene polymorphism in primary spontaneous intracerebral hemorrhage (PSICH) and ischemic stroke (IS).

Methods

193 PSICH, 272 IS and 188 controls were included from the same geographical area. The demographic and clinical stroke risk factors were noted. PSICH was confirmed by CT and IS by MRI. The location of stroke and size were noted. ACT gene polymorphism was analyzed by polymerase chain reaction. The ACT genotype and allele frequency in PSICH, IS and controls were compared.

Results

The age of the PSICH was 56.9±13years, IS 54±16.7years and controls 54.8±10years. 134 females were in study and 65 in control groups. In the controls the AA genotype was 30%, AT 51.1% and TT in 16% whereas these were 39.3%, 53% and 7.7% in PSICH and 34.6%, 53.3% and 12.1% in IS. The frequency of T allele in controls was 41.5%, PSICH 34.2% and IS 38.6%. There was no significant difference in genotype and allele frequency in PSICH, IS and controls as well as location and etiology of stroke.

Interpretation

The ACT genotype and allele frequency are not different in Indian PSICH and IS compared to controls.

Keywords: ACT gene polymorphism, ICH, Stroke