Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 90-95 , 15 March 2010

The novel radical scavenger IAC is effective in preventing and protecting against post-ischemic brain damage in Mongolian gerbils

  • Donatella Canistro

      Affiliations

    • Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48-40126 Bologna, Italy
    • ,
  • Alessandra A. Affatato

      Affiliations

    • Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48-40126 Bologna, Italy
    • ,
  • Antonio Soleti

      Affiliations

    • Medestea Research, Via Cernaia, 31-10121 Torino, Italy
    • ,
  • Vincenzo Mollace

      Affiliations

    • Faculty of Pharmacy, University of Catanzaro “Magna Graecia”, Complesso Nini' Barbieri, Roccelletta di Borgia, 88100, Catanzaro, Italy
    • IRCCS San Raffaele Pisana, Via della Pisana, 235, Rome, Italy
    • ,
  • Carolina Muscoli

      Affiliations

    • Faculty of Pharmacy, University of Catanzaro “Magna Graecia”, Complesso Nini' Barbieri, Roccelletta di Borgia, 88100, Catanzaro, Italy
    • IRCCS San Raffaele Pisana, Via della Pisana, 235, Rome, Italy
    • ,
  • Francesca Sculco

      Affiliations

    • Faculty of Pharmacy, University of Catanzaro “Magna Graecia”, Complesso Nini' Barbieri, Roccelletta di Borgia, 88100, Catanzaro, Italy
    • ,
  • Iolanda Sacco

      Affiliations

    • Faculty of Pharmacy, University of Catanzaro “Magna Graecia”, Complesso Nini' Barbieri, Roccelletta di Borgia, 88100, Catanzaro, Italy
    • ,
  • Valeria Visalli

      Affiliations

    • Faculty of Pharmacy, University of Catanzaro “Magna Graecia”, Complesso Nini' Barbieri, Roccelletta di Borgia, 88100, Catanzaro, Italy
    • ,
  • Barbara Bonamassa

      Affiliations

    • Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48-40126 Bologna, Italy
    • ,
  • Manuela Martano

      Affiliations

    • Medestea Research, Via Cernaia, 31-10121 Torino, Italy
    • ,
  • Michelangelo Iannone

      Affiliations

    • Faculty of Pharmacy, University of Catanzaro “Magna Graecia”, Complesso Nini' Barbieri, Roccelletta di Borgia, 88100, Catanzaro, Italy
    • IRCCS San Raffaele Pisana, Via della Pisana, 235, Rome, Italy
    • ,
  • Andrea Sapone

      Affiliations

    • Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48-40126 Bologna, Italy
    • ,
  • Moreno Paolini

      Affiliations

    • Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48-40126 Bologna, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 051 2096330; fax: +39 051 2096331.

Received 17 October 2008 ,Revised 22 October 2009 ,Accepted 29 October 2009.

References 

  1. Levi DE, Caronna JJ, Singer BH, Lapinski RH, Frydman H, Plum F. Predicting outcome from hypoxic–ischemic coma. JAMA. 1985;253:1420–1426
  2. Pulsinelli WA, Brady JN, Marchick MR, Bourdi M, George JW, Radonovich MF, et al. A protective role for cycloxygenase-2 in drug-induced liver injury in mice. Chem Res Toxicol. 1982;14:1620–1628
  3. Kirino T. Delayed neuronal death. Neuropathology. 2000;20:S95–97Suppl
  4. Wolfe CD. The impact of stroke. Br Med Bull. 2000;56:275–286
  5. Barber PA, Auer RN, Buchan AM, Sutherland GR. Understanding and managing ischemic stroke. Can J Physiol Pharmacol. 2001;79:283–296
  6. Muscoli C, Mollace V, Wheatley J, Masini E, Ndengele M, Wang ZQ, et al. Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-d-aspartate-mediated hyperalgesia. Pain. 2004;111:96–103
  7. Ajith TA, Riji T, Anu V. In vitro anti-oxidant and DNA protective effects of the novel 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor rosuvastatin. Clin Exp Pharmacol Physiol. 2008;35:625–629
  8. Cuzzocrea S, McDonald MC, Mazzon E, Siriwardena D, Costantino G, Fulia F, et al. Effects of Tempol, a membrane permeable radical scavenger, in a gerbil model of brain injury. Brain Res. 2000;875:96–106
  9. Al-Omar FA, Nagi MN, Abdulgadir MM. Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus. Neurochem Res. 2006;31:611–618
  10. Gaspar MM, Boerman OC, Laverman P, Corvo ML, Storm G, Cruz ME. Enzymosomes with surface-exposed superoxide dismutase: in vivo behaviour and therapeutic activity in a model of adjuvant arthritis. J Control Release. 2007;117:186–195
  11. Aston K, Rath N, Naik A, Slomczynska U, Schall OF, Riley DP. Computer-aided design (CAD) of Mn (II) complexes: superoxide dismutase mimetics with catalytic activity exceeding the native enzyme. Inorg Chem. 2001;40:1779–1789
  12. Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Modesti A, et al. The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils. BMC Pharmacol. 2003;3:8–16
  13. Samlowski WE, Petersen R, Cuzzocrea S, Macarthur H, Burton D, McGregor JR, et al. A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects. Nat Med. 2003;9:750–755
  14. Perel P, Roberts I, Sena E, Wheble P, Briscole C, Sancercock P, et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ. 2007;334:197–206
  15. Novelli M, D'Aleo V, Lupi R, Paolini M, Soleti A, Marchetti P, et al. Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model. Pancreas. 2007;35:e10–17
  16. Lupi R, Del Guerra S, Bancarella R, Novelli M, Valgimigli L, Peduli GF, et al. Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger. Diabetes Metab. 2007;33:340–345
  17. Valgimigli L, Pedulli GF, Paolini M. Measurement of oxidative stress by EPR radical-probe technique. Free Radic Biol Med. 2001;31:708–716
  18. Ohkawa H, Ohishi H, Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358
  19. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 1982;239:57–69
  20. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 1982;239:57–69
  21. Colbourne F, Li H, Buchan AM. Continuing post-ischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats. Stroke. 1999;30:662–668
  22. Oliver CN, Starke-Reed PE, Stadtman ER, Liu GJ, Carney JM, Floyd RA. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. PNAS USA. 1990;87:5144–5147
  23. Margaill I, Plotkine M, Lerouet D. Antioxidant strategies in the treatment of stroke. Free Radic Biol Med. 2005;39:429–443
  24. Liu PK, Grossman RG, Hsu CY, Robertson CS. Ischemic injury and faulty gene transcripts in the brain. Trends Neurosci. 2001;24:581–588
  25. Chan PH. Role of oxidants in ischemic brain damage. Stroke. 1996;27:1124–1129
  26. Knuckey NW, Palm D, Primiano M, Epstein MH, Johanson CE. N-acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats. Stroke. 1995;26:305–311
  27. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001;21:2–14
  28. Candelario-Jalil E, Mhadu NH, Ai-Dalain SM, Martinez G, Leon OS. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res. 2001;41:233–241
  29. Al-Nita D, Nita V, Spulber S, Moldovan M, Popa DP, Zagrean AM, et al. Oxidative damage following cerebral ischemia depends in reperfusion—a biochemical study in rat. J Cell Mol Med. 2001;5:163–170
  30. Al-Majed AA, Al-Omar FA, Nagi MN. Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur J Pharmacol. 2006;543:40–47
  31. Homi HM, Freitas JJS, Curi R, Velasco IT, Junior BAS. Changes in superoxide dismutase and catalase activities of rat brain regions during early global transient ischemia/reperfusion. Neurosci Lett. 2002;333:37–40
  32. Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, et al. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci. 1998;18:205–213
  33. Sheng H, Bart RD, Oury TD, Pearlstein RD, Crapo JD, Warner DS. Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience. 1999;88:185–191
  34. Nurmi A, Miettinen TK, Puoliväli J, Pussinen R, Soleti A, Bagate K, et al. Neuroprotective properties of the non-peptidyl radical scavenger IAC in rats following transient focal cerebral ischemia. Brain Res. 2008;1207:174–181
  35. Sena E, Wheble P, Sandercock P, Macleod M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke. 2007;38:388–394
  36. Kuroda S, Tsuchidate R, Smith ML, Maples KR, Siesjö BK. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 1999;19:778–787
  37. van der Worp HB, Kappelle LJ, Algra A, Bär PR, Orgogozo JM, Ringelstein EB, et al. The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. Neurology. 2002;58:133–135
  38. Sydserff SG, Borelli AR, Green AR, Cross AJ. Differential neuroprotective effects for three GABA-potentiating compounds in a model of hypoxia–ischemia. Brain Res. 2002;1035:196–205
  39. Salom JB, Pérez-Asensio FJ, Burguete MC, Marín N, Pitarch C, Torregrosa G, et al. Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia. Eur J Pharmacol. 2004;495:55–62
  40. Green AR, Ashwood T. Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers. Curr Drug Targets CNS Neurol Disord. 2005;4:109–118
  41. Doggrell SA. Nitrone spin on cerebral ischemia. Curr Opin Investig Drugs. 2006;7:20–24
  42. Koziol JA, Feng AC. On the analysis and interpretation of outcome measures in stroke clinical trials: lessons from the SAINT I study of NXY-059 for acute ischemic stroke. Stroke. 2006;37:2644–2647
  43. Hill MD. Stroke: the dashed hopes of neuroprotection. Lancet. 2007;6:1–2
  44. Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J. Vitamin C exhibits pro-oxidant properties. Nature. 1998;392:559
  45. Paolini M, Abdel-Rahman SZ, Cantelli-Forti G, Legator MS. Chemoprevention or antichemoprevention? A salutary warning from the beta-carotene experience. J Natl Cancer Inst. 2001;93:1110–1111
  46. Louwerse ES, Weverling GW, Bossuyt PMM, Meyjes FEP, de Jong V. Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol. 1995;52:559–564
  47. Andreassen OA, Dedeoglu A, Klivenyi P, Beal MF, Bush AI. N-acetyl-l-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. NeuroReport. 2000;11:2491–2493
  48. Desnuelle C, Dib M, Garrel C, Favier AA. A double-blind, placebo controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS Riluzole-Tocopherol Study Group. Amyotroph Lateral Scler Other Mot Neuron Disord. 2001;2:9–18
  49. Graf M, Ecker D, Horowski R, Kramer B, Riederer P, Gerlach M, et al. German vitamin E/ALS Study Group High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study. J Neural Transm. 2005;113:649–660
  50. Orrell RW, Lane RJM, Ross M. Cochrane database of systematic reviews. Cochrane Database Syst Rev. 2007;1:CD002829
  51. The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med. 1993;328:176–183
  52. Boothby LA, Doering PL. Vitamin C and vitamin E for Alzheimer's disease. Anna Pharmacother. 2005;39:2073–2080
  53. Pham DQ, Plakogiannis R. Vitamin E supplementation in Alzheimer's disease, Parkinson's disease, tardive dyskinesia, and cataract: Part 2. Ann Pharmacother. 2005;39:2065–2072
  54. Weber CA, Ernst ME. Antioxidants, supplements and Parkinson's disease. Ann Pharmacother. 2006;40:935–938
  55. Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS ACTS Study Group. Vitamins C and E and the risks of pre-eclampsia and perinatal complications. N Engl J Med. 2006;354:1796–1806
  56. Poston L, Brileym AL, Seed PT, Kelly FJ, Shennan AH. Vitamins In Pre-eclampsia (VIP) Trial Consortium. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet. 2006;367:1145–1154
  57. Cho E, Hunter DJ, Spiegelman D, Albanes D, Beeson WL, van den Brandt PA, et al. Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies. Int J Cancer. 2006;118:970–978
  58. Bleys J, Miller ER, Pastor-Barriuso R, Appel LJ, Guallar E. Vitamin–mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2006;84:880–887
  59. Rak R, Chao DL, Pluta RM, Mitchell JB, Oldfield EH, Watson JC. Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia. J Neurosurg. 2000;92:646–651

PII: S0022-510X(09)00941-1

doi: 10.1016/j.jns.2009.10.023

Journal of the Neurological Sciences
Volume 290, Issue 1 , Pages 90-95 , 15 March 2010

Article Tools

* Image Usage & Resolution