Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 42-44 , 15 January 2010

The effect of war stress on multiple sclerosis exacerbations and radiological disease activity

  • Bassem Yamout

      Affiliations

    • Department of Internal Medicine, American University of Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
  • ,
  • Salam Itani

      Affiliations

    • Department of Internal Medicine, American University of Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
  • ,
  • Roula Hourany

      Affiliations

    • Department of Radiology, American University of Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
  • ,
  • Abla Mehio Sibaii

      Affiliations

    • Department of Epidemiology and Population, American University of Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
  • ,
  • Shadi Yaghi

      Affiliations

    • Department of Internal Medicine, American University of Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, American University of Beirut – Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon. Tel.: +961 1 344042; fax: +961 1 751517.

Received 30 July 2009 ,Revised 4 September 2009 ,Accepted 9 October 2009.

References 

  1. Mitsonis CI, Potagas C, Zervas I, Sfagos K. The effects of stressful life events on the course of multiple sclerosis: a review. Int J Neurosci. 2009;119(3):315–335
  2. Gold SM, Christoph H. Stress and disease progression in multiple sclerosis and its animal models. Neuroimmunomodulation. 2006;13:318–326
  3. Mitsonis CI, Zervas IM, Mitropoulos PA, Dimopoulos NP, Soldatos CR, Potagas CM. The impact of stressful life events on risk of relapse in women with multiple sclerosis: a prospective study. Eur Psychiatry. 2008;23(7):497–504Oct
  4. Mohr DC. Stress and multiple sclerosis. J Neurol. 2007;254(Suppl 2):II65–II68May
  5. Nisipeanu P, Korczyn AD. Psychological stress as risk factor for exacerbations in multiple sclerosis. Neurology. 1993;43:1311–1312
  6. Mohr DC, Goodkin DE, Nelson S, Cox D, Weiner M. Moderating effects of coping on the relationship between stress and the development of new brain lesions in multiple sclerosis. Psychosom Med. 2002;64(5):803–809
  7. Mohr DC, Goodkin DE, Bacchetti P, Boudewyn AC, Huang L, Marrietta P, et al. Psychological stress and the subsequent appearance of new brain MRI lesions in MS. Neurology. 2000;55(1):55–6112
  8. Yamout B. Extreme circumstances, extraordinary measures. Good Clinical Practice Journal 2008 Mar;1–3.
  9. Golan D, Somer E, Dishon S, Cuzin-Disegni L, Miller A. Impact of exposure to war stress on exacerbations of multiple sclerosis. Ann Neurol. 2008;64(2):143–148
  10. Goodin DS. The impact of war-stress on MS exacerbations. Ann Neurol. 2008;64(2):114–115
  11. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005;58(6):840–846Dec
  12. Kurtzke JF. Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33:1444–1452
  13. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol. 2001;50(1):121–127Jul
  14. Miller DH, Barkhof F, Nauta JJ. Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain. 1993;116(Pt 5):1077–1094Oct
  15. Koudriavtseva T, Thompson AJ, Fiorelli M, Gasperini C, Bastianello S, Bozzao A. Gadolinium enhanced MRI predicts clinical and MRI disease activity in relapsing–remitting multiple sclerosis. J Neurol Neurosurg Psychiatry. 1997;62(3):285–287Mar
  16. Apel A, Klauer T, Zettl UK. Stress and progression in multiple sclerosis. Fortschr Neurol Psychiatr. 2006;74(10):567–574Oct, Epub 2006 Jan 2
  17. Brown RF, Tennant CC, Sharrock M, Hodgkinson S, Dunn SM, Pollard JD. Relationship between stress and relapse in multiple sclerosis: Part II. Direct and indirect relationships. Mult Scler. 2006;12(4):465–475Aug
  18. Ackerman KD, Heyman R, Rabin BS, Anderson BP, Houck PR, Frank E. Stressful life events precede exacerbations of multiple sclerosis. Psychosom Med. 2002;64(6):916–920Nov–Dec
  19. Mohr DC, Hart SL, Julian L, Cox D, Pelletier D. Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis. BMJ. 2004;328(7442):731;Mar 27
  20. Mohr DC, Pelletier D. A temporal framework for understanding the effects of stressful life events in inflammation in patients with multiple sclerosis. Brain Behav Immun. 2006;20(1):27–36Jan
  21. Theoharides TC. Mast cell and stress—a psychoneuroimmunological perspective. J Clin Psychopharmacol. 2002;22(2):103–108Apr
  22. Zappulla JP, Arock M, Mars LT, Liblau RS. Mast cells: new targets for multiple sclerosis therapy. J Neuroimmunol. 2002;131(1–2):5–20Oct
  23. Theoharides TC, Konstantinidou AD. Corticotropin-releasing hormone and the blood-brain-barrier. Front Biosci. 2007;2:1615–1628
  24. Esposito P, Gheorghe D, Kandere K, Pang X, Connolly R, Jacobson S. Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells. Brain Res. 2001;888(1):117–127Jan 5
  25. Lalive PH, Burkhard PR, Chofflon M. TNF-alpha and psychologically stressful events in healthy subjects: potential relevance for multiple sclerosis relapse. Behav Neurosci. 2002;116(6):1093–1097
  26. Gold SM, Mohr DC, Huitinga I, Flachenecker P, Sternberg EM, Heesen C. The role of stress-response systems for the pathogenesis and progression of MS. Trends Immunol. 2005;26(12):644–652Dec
  27. Heesen C, Mohr DC, Huitinga I, Bergh FT, Gaab J, Otte C. Stress regulation in multiple sclerosis—current issues and concepts. Mult Scler. 2007;13(2):143–148Mar
  28. Michelson D, Stone L, Galliven E, Magiakou MA, Chrousos GP, Sternberg EM. Multiple sclerosis is associated with alterations in hypothalamic–pituitary–adrenal axis function. J Clin Endocrinol Metab. 1994;79(3):848–853Sep

PII: S0022-510X(09)00908-3

doi: 10.1016/j.jns.2009.10.012

Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 42-44 , 15 January 2010