Reversible acute leukoencephalopathy as a form of presentation in cerebral amyloid angiopathy
Received 17 June 2009; received in revised form 9 September 2009; accepted 30 September 2009. published online 26 October 2009.
Abstract
Background
Cerebral amyloid angiopathy (CAA) may present as cerebral haemorrhage, cerebral infarction and periventricular white matter lesions. Reversible leukoencephalopathy is a rare manifestation of CAA.
Aims of the study
To describe two patients with reversible acute leukoencephalopathy as the first manifestation of CAA.
Patients
Two consecutive patients were admitted to our neurology department with transient focal neurological symptoms. They showed reversible focal leukoencephalopathy on magnetic resonance imaging (MRI). CAA was finally diagnosed in both, and pathologically confirmed in one. The latter patient showed multiple foci of petechial bleeding in the cortex and subcortex in T2-weighted GRE sequences, suggestive of CAA.
Conclusion
Reversible acute focal leukoencephalopathy may be an infrequent clinical and radiological pattern of CAA.
ABSTRACT