Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 88-91 , 15 January 2010

Hypoperfusion of the motor cortex associated with parkinsonism in dementia with Lewy bodies

  • Ryuichi Takahashi

      Affiliations

    • Department of Neurology, Nishi-Kobe Medical Center, Kobe, Hyogo, Japan
    • Corresponding Author InformationCorresponding author. Kohjidai 5-7-1, Nishi-ku, Kobe, Hyogo 651-2273, Japan. Tel.: +81 078 997 2200; fax: +81 078 993 3728.
    • ,
  • Kazunari Ishii

      Affiliations

    • Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan
    • Department of Radiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    • ,
  • Kenichi Shimada

      Affiliations

    • Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan
    • ,
  • Shingo Ohkawa

      Affiliations

    • Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan
    • ,
  • Yo Nishimura

      Affiliations

    • Department of Neurology, Nishi-Kobe Medical Center, Kobe, Hyogo, Japan

Received 3 August 2009 ,Revised 24 September 2009 ,Accepted 29 September 2009.

References 

  1. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863–1872
  2. Ishii K, Imamura T, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, et al. Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease. Neurology. 1998;51(1):125–130
  3. Higuchi M, Tashiro M, Arai H, Okamura N, Hara S, Higuchi S, et al. Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol. 2000;162(2):247–256
  4. Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl DE. Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol. 2001;50(3):358–365
  5. Ishii K, Hosaka K, Mori T, Mori E. Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies. Ann Nucl Med. 2004;18(5):447–451
  6. Small GW. Neuroimaging as a diagnostic tool in dementia with Lewy bodies. Dement Geriatr Cogn Disord. 2004;17(Suppl 1):25–31
  7. Ishii K, Yamaji S, Kitagaki H, Imamura T, Hirono N, Mori E. Regional cerebral blood flow difference between dementia with Lewy bodies and AD. Neurology. 1999;53(2):413–416
  8. Ishii K, Soma T, Kono AK, Sofue K, Miyamoto N, Yoshikawa T, et al. Comparison of regional brain volume and glucose metabolism between patients with mild dementia with Lewy bodies and those with mild Alzheimer's disease. J Nucl Med. 2007;48(5):704–711
  9. Kono AK, Ishii K, Sofue K, Miyamoto N, Sakamoto S, Mori E. Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer's disease using FDG-PET and 3D-SSP. Eur J Nucl Med Mol Imaging. 2007;34(9):1490–1497
  10. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47(5):1113–1124
  11. Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 2007;68(11):812–819
  12. Kudo Y, Horikawa Y, Noda T, Eguchi I, Watanabe Y, Wakabayashi K. The clinical features of patients with probable dementia with Lewy bodies—report of 4 cases. Rinsho Shinkeigaku. 1999;39(4):423–430
  13. Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, et al. Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. Neurology. 2001;56(5):643–649
  14. Albin RL, Minoshima S, D'Amato CJ, Frey KA, Kuhl DA, Sima AA. Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology. 1996;47(2):462–466
  15. Huang C, Tang C, Feigin A, Lesser M, Ma Y, Pourfar M, et al. Changes in network activity with the progression of Parkinson's disease. Brain. 2007;130(Pt 7):1834–1846
  16. Wichmann T, DeLong MR. Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder. Ann NY Acad Sci. 2003;991:199–213
  17. Parent A, Hazrati LN. Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Brain Res Rev. 1995;20(1):91–127
  18. Brooks DJ. Motor disturbance and brain functional imaging in Parkinson's disease. Eur Neurol. 1997;38(Suppl 2):26–32
  19. Thobois S, Dominey PF, Decety J, Pollak PP, Gregoire MC, Le Bars PD, et al. Motor imagery in normal subjects and in asymmetrical Parkinson's disease: a PET study. Neurology. 2000;55(7):996–1002
  20. Brooks DJ. PET and SPECT studies in Parkinson's disease. Baillieres Clin Neurol. 1997;6(1):69–87
  21. Wielepp JP, Burgunder JM, Pohle T, Ritter EP, Kinser JA, Krauss JK. Deactivation of thalamocortical activity is responsible for suppression of parkinsonian tremor by thalamic stimulation: a 99mTc-ECD SPECT study. Clin Neurol Neurosurg. 2001;103(4):228–231
  22. Sabatini U, Boulanouar K, Fabre N, Martin F, Carel C, Colonnese C, et al. Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain. 2000;123(Pt 2):394–403
  23. Nagano-Saito A, Kato T, Arahata Y, Washimi Y, Nakamura A, Abe Y, et al. Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies. Neuroimage. 2004;22(2):553–561
  24. Feigin A, Fukuda M, Dhawan V, Przedborski S, Jackson-Lewis V, Mentis MJ, et al. Metabolic correlates of levodopa response in Parkinson's disease. Neurology. 2001;57(11):2083–2088
  25. Hilker R, Voges J, Thiel A, Ghaemi M, Herholz K, Sturm V, et al. Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET. J Neural Transm. 2002;109(10):1257–1264
  26. Haslinger B, Erhard P, Kampfe N, Boecker H, Rummeny E, Schwaiger M, et al. Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa. Brain. 2001;124(Pt 3):558–570
  27. Rascol O, Sabatini U, Brefel C, Fabre N, Rai S, Senard JM, et al. Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia. Brain. 1998;121(Pt 3):527–533
  28. Buhmann C, Glauche V, Sturenburg HJ, Oechsner M, Weiller C, Buchel C. Pharmacologically modulated fMRI—cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain. 2003;126(Pt 2):451–461
  29. Harding AJ, Broe GA, Halliday GM. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain. 2002;125(Pt 2):391–403
  30. Perneczky R, Drzezga A, Boecker H, Forstl H, Kurz A, Haussermann P. Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations. Dement Geriatr Cogn Disord. 2008;25(6):531–538

PII: S0022-510X(09)00893-4

doi: 10.1016/j.jns.2009.09.033

Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 88-91 , 15 January 2010

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