Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 194-196 , 15 January 2010

Clinical manifestations, diagnostic criteria and therapy of Hashimoto's encephalopathy: Report of two cases

  • Milija Mijajlovic

      Affiliations

    • Institute of Neurology, Clinical Center of Serbia, Dr Subotica 6, 11000 Belgrade, Serbia
    • Corresponding Author InformationCorresponding author. Tel.: +381 11 2887348; fax: +381 11 2684 577.
    • ,
  • Mihailo Mirkovic

      Affiliations

    • Department of Neurology, General hospital Valjevo Sindjeliceva 62, 14000 Valjevo, Serbia
    • ,
  • Jelena Dackovic

      Affiliations

    • Institute of Neurology, Clinical Center of Serbia, Dr Subotica 6, 11000 Belgrade, Serbia
    • ,
  • Jasna Zidverc-Trajkovic

      Affiliations

    • Institute of Neurology, Clinical Center of Serbia, Dr Subotica 6, 11000 Belgrade, Serbia
    • ,
  • Nadezda Sternic

      Affiliations

    • Institute of Neurology, Clinical Center of Serbia, Dr Subotica 6, 11000 Belgrade, Serbia

Received 21 July 2009 ,Revised 23 September 2009 ,Accepted 28 September 2009.

References 

  1. Brain L, Jellinek EH, Ball K. Hashimoto's disease and encephalopathy. Lancet. 1966;2:512–514
  2. Chong JY, Rowland LP, Utiger RD. Hashimoto encephalopathy: syndrome or myth?. Arch Neurol. 2003;60:164–171
  3. Shaw PJ, Walls TJ, Newman PK, Cleland PG. Hashimoto's encephalopathy a steroid responsive disorder associated with high anti-thyroid antibody titers. Report of 5 cases. Neurology. 1991;41:228–233
  4. Henchey R, Cibula J, Helveston W, Malone J, Gilmore RL. Electroencephalographic findings in Hashimoto's encephalopathy. Neurology. 1995;45:977–981
  5. Ghika-Schmid F, Ghika J, Regli F, Dworak N, Bogousslavsky J, Städler C, et al. Hashimoto's myoclonic encephalopathy: an underdiagnosed treatable condition?. Mov Disord. 1996;11:555–562
  6. Kothbauer-Margreiter I, Sturzenegger M, Komor J, Baumgartner R, Hess CW. Encephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment.. J Neurol. 1996;243:585–593
  7. Peschen-Rosin R, Schabet M, Dichgans J. Manifestation of Hashimoto's encephalopathy years before onset of thyroid disease. Eur Neurol. 1999;41:79–84
  8. Galluzzi S, Geroldi C, Zanetti O, Frisoni GB. Hashimoto's encephalopathy in the elderly: relationship to cognitive impairment. J Geriatr Psychiatry Neurol. 2002;15:175–179
  9. Forchetti CM, Katsamakis G, Garron DC. Autoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism. Neurology. 1997;49:623–626
  10. Seipelt M, Zerr I, Nau R, Mollenhauer B, Kropp S, Steinhoff BJ, et al. Hashimoto's encephalitis as a differential diagnosis of Creutzfeldt–Jakob disease. J Neurol Neurosurg Psychiatry. 1999;66:172–176
  11. Doherty CP, Schlossmacher M, Torres N, Bromfield E, Samuels MA. Hashimoto's encephalopathy mimicking Creutzfeldt–Jakob disease: brain biopsy findings. J Neurol Neurosurg Psychiatry. 2002;73:601–602
  12. Oide T, Tokuda T, Yazaki M, Watarai M, Mitsuhashi S, Kaneko K, et al. Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients. J Neurol Sci. 2004;217:7–12
  13. Takahashi S, Mitamura R, Itoh Y, Suzuki N, Okuno A. Hashimoto encephalopathy: etiologic considerations. Pediatr Neurol. 1994;11:328–331
  14. Hartmann M, Schaner B, Scheglmann K, Bucking A, Pfiste R. Hashimoto enzephalopathie. Nervenarzt. 2000;71:489–494
  15. Nolte KW, Unbehaun A, Sieker H, Kloss TM, Paulus W. Hashimoto encephalopathy: a brainstem vasculitis?. Neurology. 2000;54:769–770
  16. Ferracci F, Moretto G, Candeago RM, Cimini N, Conte F, Gentile M, et al. Antithyroid antibodies in the CSF: their role in the pathogenesis of Hashimoto's encephalopathy. Neurology. 2003;60:712–714
  17. Ferracci F, Carnevale A. The neurological disorder associated with thyroid autoimmunity. J Neurol. 2006;253:975–984
  18. Karadeniz M, Erdogan M, Özgen AG. Hashimoto's encephalopathy. Turkish J Endocrinol Metab. 2005;2:33–43
  19. Magy L, Vallat JS. Hashimoto's encephalitis. Rev Neurol (Paris). 2002;158:966–970
  20. Archambeaud F, Galinat S, Regouby Y, Magy L, Rebeyrotte I, Vallat JM, et al. Hashimoto encephalopathy. Analysis of four case reports. La Revue de Médicine Interne. 2001;22:653–659
  21. Ferracci F, Bertiato G, Moretto G. Hashimoto's encephalopathy: epidemiologic data and pathogenetic considerations. J Neurol Sci. 2004;217:165–168
  22. Katoh N, Yoshida T, Shimojima Y, Gono T, Matsuda M, Yoneda M, et al. An 85-year-old case with Hashimoto's encephalopathy, showing spontaneous complete remission. Intern Med. 2007;46:1613–1616
  23. Boers PM, Colebatch JG. Hashimoto's encephalopathy responding to plasmapheresis. J Neurol Neurosurg Psychiatry. 2002;73:601
  24. Jacob S. Y A Rajabally, Hashimoto's encephalopathy: steroid resistance and response to intravenous immunoglobulins. J Neurol Neurosurg Psychiatry. 2005;76:455–456

PII: S0022-510X(09)00890-9

doi: 10.1016/j.jns.2009.09.030

Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 194-196 , 15 January 2010

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