Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 147-150, 15 January 2010

Features of intrathecal immunoglobulins in patients with multiple sclerosis

  • Franziska Di Pauli

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Viktoria Gredler

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Bettina Kuenz

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Andreas Lutterotti

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Rainer Ehling

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Claudia Gneiss

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Michael Schocke

      Affiliations

    • Department of Radiology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Florian Deisenhammer

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Markus Reindl

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Thomas Berger

      Affiliations

    • Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 512 504 26277; fax: +43 512 504 24260.

Received 28 July 2009; received in revised form 15 September 2009; accepted 17 September 2009. published online 15 October 2009.

Abstract 

We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and paraclinical parameters were not associated with a specific Ig isotype or subclass profile. Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts.

Keywords: Multiple sclerosis, Immunoglobulins, Subclasses, Cerebrospinal fluid, Progression, Oligoclonal bands, Disease course, B cells

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PII: S0022-510X(09)00859-4

doi:10.1016/j.jns.2009.09.016

Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 147-150, 15 January 2010

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