Journal of the Neurological Sciences
Volume 287, Issue 1 , Pages 60-63 , 15 December 2009

Role of the Oral Glucose Tolerance Test (OGTT) in the idiopathic restless legs syndrome

  • Domenico Bosco

      Affiliations

    • Department of Neuroscience, “S. Giovanni di Dio” Hospital, 88900, Crotone, Italy
    • Corresponding Author InformationCorresponding author. Department of Neuroscience, “S. Giovanni di Dio” Hospital, Via Largo Bologna, 88900, Crotone, Italy. Tel.: +39 0962 92 42 41; fax: +39 0962 92 45 61.
    • ,
  • Massimiliano Plastino

      Affiliations

    • Department of Neuroscience, “S. Giovanni di Dio” Hospital, 88900, Crotone, Italy
    • ,
  • Antonietta Fava

      Affiliations

    • Endocrinology, Department of Clinical and Experimental Medicine, Campus Universitario, loc. Germaneto, University “Magna Graecia”, 88100, Catanzaro, Italy
    • ,
  • Maria Ettore

      Affiliations

    • Department of Neuroscience, “S. Giovanni di Dio” Hospital, 88900, Crotone, Italy
    • ,
  • Francesca Bosco

      Affiliations

    • Pharmacology, Course of Clinical Pharmacy, loc. Roccelletta, University “Magna Graecia”, 88100 Catanzaro, Italy
    • ,
  • Caterina Ermio

      Affiliations

    • Department of Neuroscience, “S. Giovanni Paolo II” Hospital, 88046, Lamezia Terme, Italy
    • ,
  • Federico Tallarigo

      Affiliations

    • Serv. of Anatomo-Pathology, “S. Giovanni di Dio” Hospital, 88900, Crotone, Italy
    • ,
  • Domenico Pirritano

      Affiliations

    • Neurology, Department of Medical Science, Campus Universitario, loc. Germaneto, University “Magna Graecia”, 88100, Catanzaro, Italy
    • ,
  • Domenico Consoli

      Affiliations

    • Department of Neuroscience, “G. Jazzolino” Hospital, 89900, Vibo Valentia, Italy

Received 10 April 2009 ,Revised 4 September 2009 ,Accepted 8 September 2009.

References 

  1. American Academy of Sleep Medicine. International Classification of Sleep Disorders, 2nd edn (ICSD-2). Diagnostic and coding manual. American Academy of Sleep Medicine, Westchaster, IL 2006.
  2. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless Legs Syndrome diagnosis and epidemiology workshop at the national institute of health in collaboration with members of the international Restless Legs Syndrome Study Group. In: RLS: Diagnostic criteria, special considerations and epidemiology. 4:2003;p. 101–119
  3. Winkelmann J, Wetter TC, Collado-Seidel V, Gasser T, Dichgans M, Yassouridis A, et al. Clinical characteristics and frequency of the hereditary RLS in a population of 300 patients. Sleep. 2000;23:597–602
  4. Clemens S, Rye D, Hochman S. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology. 2006;67:125–130
  5. Okeeffe ST, Gavin K, Lavan JN. Iron status and Restless Legs Syndrome in the elderly. Age Ageing. 1994;23:200–203
  6. Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S, et al. Restless legs syndrome in end stage renal disease. Sleep Med. 2004;5:309–315
  7. Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I, et al. Restless legs syndrome and pregnancy. Neurology. 2004;63:1065–1069
  8. Rutkove SB, Matheson JR, Logigian EL. Restless legs syndrome in patients with polyneuropathy. Muscle Nerve. 1996;19:670–672
  9. Skomro RP, Ludwig S, Salamon E, Kryger MH. Sleep complaints and restless legs syndrome in adult type 2 diabetes. Sleep Med. 2001;2:417–422
  10. Polydefkis M, Allen RP, Hauer P, Earley CJ, Griffin JW, Mc Arthun JC. Subclinical sensory neuropathy in late-onset restless legs syndrome. Neurology. 2000;55:115–121
  11. Hoitsma E, Reulen JP, De Baets M, Drent M, Spaans F, Faber CG. Small fibre neuropathy: a common and important clinical disorder. J Neurol Sci. 2004;227:119–130
  12. Lauria G, Cornblath DR, Johansson O, McArthur JC, Mellgren SL, Nolano M, et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol. 2005;12:747–758
  13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  14. Genuth S, Alberti KG, Bennett P. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;52:833–837
  15. Summer C, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology. 2003;60:108–111
  16. Dyck PJ, Devies JL, Wilson DM, Service FJ, Melton LJ, O'Brien PC. Risk factors for severity of diabetic polyneuropathy: intensive longitudinal assessment of the Rochester Diabetic Neuropathy Study Cohort. Diabetes Care. 1999;22:1479–1486
  17. Lopes LA, De MM LinsC, Adeodato VG, Quental DP, Debruin PFC, Montenegro RM, et al. Restless legs syndrome and quality of sleep in type 2 diabetes. Diabetes Care. 2005;28:2633–2636
  18. Merlino G, Fratticci L, Valente M, Del Giudice A, Noacco C, Dolso P, et al. Association of restless legs syndrome in type 2 diabetes: a case-control study. Sleep. 2007;30:866–871
  19. Gemignani F, Brindani F, Vitetta F, Murbini A, Calzetti S. Restless legs syndrome in diabetic neuropathy: a frequent manifestation of small fibre neuropathy. J Peripher Nerv Syst. 2007;12:50–53
  20. Russel JW, Feldman EL. Impaired glucose tolerance. Does it cause neuropathy?. Muscle Nerve. 2001;24:1109–1112
  21. Ǿrstavik K, Namer B, Schmidt R, Schmeltz M, Hiliges M, Weidner C, et al. Abnormal function of C-fibres in patients with neuropathy. J Neurosci. 2006;26:11287–11294
  22. Gallello M, Setien R, Izquierdo MJ, Casis O, Casis E. Diabetes-induced biochemical changes in central and peripheral catecholaminergic systems. Psysiol Res. 2003;52:735–741
  23. Ondo WG, Zhang X, Xie WJ, Pan TH, Le WD. Clinical correlates of 6-hydroxydopamine injections into all dopaminergic neurons in rats: a possible model for RLS. Mov Disord. 2000;15:154–158
  24. Qu S, Ondo WG, Zhang X, Xie WJ, Pan TH, Le WD. Projections of diencephalic dopamine neurones into the spinal cord in mice. Exp Brain Res. 2006;168:152–156
  25. Handwerker HO, Iggo A, Zimmermann M. segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli. Pain. 1975;1:147–165
  26. De Vigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain. 2008;13(7):1912–1925
  27. Diabetes control and complications research group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–986
  28. Singleton J, Howard J, Goldstein J, Russell J, Feldman E, Peltier A. Diet and exercise compliance decreases neuropathic pain in patients with polyneuropathy associated with prediabetes. Neurology. 2005;54:S73

PII: S0022-510X(09)00850-8

doi: 10.1016/j.jns.2009.09.008

Journal of the Neurological Sciences
Volume 287, Issue 1 , Pages 60-63 , 15 December 2009

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