Journal of the Neurological Sciences
Volume 287, Issue 1 , Pages 72-78 , 15 December 2009

Brain dysfunction in multiple chemical sensitivity

  • Ramon Orriols

      Affiliations

    • Servei de Pneumologia, Hospital Universitari Vall d' Hebron, Barcelona, Catalonia, Spain
    • CIBER Enfermedades Respiratorias (CIBERES), Spain
    • Corresponding Author InformationCorresponding author. Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Passeig Vall d' Hebron, 119-129, 08035 Barcelona, Catalonia, Spain. Tel.: +34 93 27461; fax: +34 93 2746803.
  • ,
  • Roser Costa

      Affiliations

    • Servei de Pneumologia, Hospital Universitari Vall d' Hebron, Barcelona, Catalonia, Spain
    • Servei de Pneumologia, Hospital Mutua de Terrassa, Terrassa, Catalonia, Spain
    • Facultat de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain
  • ,
  • Gemma Cuberas

      Affiliations

    • Servei de Medicina Nuclear, Hospital Universitari Vall d' Hebron, Barcelona, Catalonia, Spain
  • ,
  • Carlos Jacas

      Affiliations

    • Servei de Medicina Interna, Hospital Universitari Vall d' Hebron, Barcelona, Catalonia, Spain
  • ,
  • Joan Castell

      Affiliations

    • Servei de Medicina Nuclear, Hospital Universitari Vall d' Hebron, Barcelona, Catalonia, Spain
  • ,
  • Jordi Sunyer

      Affiliations

    • Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain
    • Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Catalonia, Spain
    • CIBER Epidemiologia y Salud Pública (CIBERESP), Spain

Received 27 January 2009 ,Revised 4 August 2009 ,Accepted 3 September 2009.

References 

  1. Sullivan JB, Bell IR, Meggs WJ. Low-level chemical sensitivity and chemical intolerance. Chapter 32 In:  Sullivan JB,  Krieger GR editor. Clinical environmental health and toxic exposures. Second Edition. Philadelphia: Lippincott Williams and Wilkins; 2001;p. 412–430
  2. Levin AS, Byers VS. Environmental illness: a disorder of immune regulation. Occup Med. 1987;2:669–681
  3. Baines CJ, McKeown-Eissen GE, Riley N, Marshall L, Jazmaji V. University of Toronto case–control study of multiple chemical sensitivity-3: intra-erythrocyctic mineral levels. Occup Med. 2007;57:137–140
  4. Schottenfeld RS. Workers with multiple chemical sensitivities: psychiatric approach to diagnosis and treatment. Occup Med. 1987;2:739–753
  5. Bell IR, Miller CS, Schwartz GE. An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationships to kindling and affective disorders. Biol Psychiatry. 1992;32:218–242
  6. Miller CS. Toxicant-induced loss of tolerance an emerging theory of disease?. Environ Health Perspect. 1997;105:445–453
  7. Meggs WJ. Neurogenia switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity. Environ Health Perspect. 1995;103:54–56
  8. Bell IR, Hardin EE, Baldwin CM, Schwartz GE. Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environ Res. 1995;70:84–97
  9. Aoty RL, Deems DA, Frye RE, Pelberg R, Shapiro A. Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities. Arch Otorhinolaryngol Head Neck Surg. 1988;144:1422–1427
  10. Szarek MJ, Bell IR, Schwartz GE. Validation of a brief screening measure of environmental chemical sensitivity: the chemical odor intolerance index. J Environ Psychol. 1997;17:345–351
  11. Metanol. NIOSH Manual of Analytical Methods (NMAM®), 4th ed. 1994. Method number 2000. Schlecht PC & O'Connor PF. Eds, Cincinnati, Oh, USA (http://www.cdc.gov/niosh/nmam/pdfs/2000.pdf).
  12. Glutaraldehyde. Adaptation of NIOSH Manual of Analytical Methods (NMAM®), 4th ed. 1994. Method number 2532. Schlecht PC & O'Connor PF. Eds, Cincinnati, Oh, USA (http://www.cdc.gov/niosh/nmam/pdfs/2532.pdf).
  13. Vapores Orgánicos. INSHT. Métodos de toma de muestras y análisis. MTA/MA-032/A98. Madrid. INSHT 1999. (http://www.mtas.es/insht/mta/MA_032_A98.htm).
  14. Bartual J., Cuenca C., Eransus F.J., Garcia-Gutiérrez M.J., Goberna R., Gomez J.A., et al. Limites de exposición profesional para Agentes Químicos. Instituto Nacional de Seguridad e Higiene en el Trabajo. Ministerio de Trabajo y Asuntos Sociales. 2001.
  15. http://www.psychology.nottingham.ca.uk/staff/cr1/mricro.html.
  16. Talairach J, Tournoux P. A co-planar stereotatic atlas of human brain. 1988;Stuttgart
  17. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, et al. Automated Talairach Atlas labels for functional brain mapping. Hum Brain Mapp. 2000;10:120–131
  18. Lezak M, Howieson DB, Loring DW. Neuropsychological assessment. 4 th ed. New York: Oxford University Press; 2004;
  19. Alonso J, Prieto L, Antó JM. La versión española del SF-36 Health Survey (Cuestionario de Salud SF-36): Un instrumento para la medida de resultados clínicos. Med Clin (Barc). 1995;104:771–776
  20. Herrero MJ, Blanch J, Peri JM, De Pablo J, Pintor L, Bulbena A. A validation study of the Hospital Anxiety and Depression Scale (HADS) in a Spanish population. Gen Hosp Psychiatry. 2003;25:277–283
  21. Miller EN. CalCAP. California computerized assessment package manual. 2nd ed. Los Angeles, California: Miller EN and Norland Software; 1986–1996;
  22. Guyton AC, Hall JE. In: Textbook of medical physiology. 10th ed. Philadelphia, PA: Saunders Company; 2000;p. 512–688
  23. Hillert L, Musabasic V, Bergglund H, Ciumas C, Savic I. Odor processing in multiple chemical sensitivity. Hum Brain Mapp. 2007;28:172–182
  24. Fiedler N, Kipen HM, DeLuca J, Kelly-McNeil K, Natelson B. A controlled comparison of multiple chemical sensitivity and chronic fatigue syndrome. Phychosom Med. 1996;58:38–49
  25. Bell IR, Kline JP, Schwartz GE, Peterson JM. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults with and without self-reported chemical odor intolerances. Int J Psichophysiol. 1998;28:23–25
  26. Bell IR. Clinically relevant EEG studies and psychophysiological findings: possible neural mechanisms for multiple chemical sensitivity. Toxicology. 1996;111:101–117
  27. Salmon PD, Heindel WC, Hamilton JM. Cognitive abilities mediated by frontal–subcortical circuits. Chapter 5. In:  Lichter DG,  Cummings JL editor. Frontal–subcortical circuits in psychiatric and neurological disorders. New York: The Guilford Press; 2001;p. 114–150
  28. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, et al. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006;114:1172–1178
  29. Das-Munshi J, Rubin GJ, Wessely S. Multiple chemical sensitivities: a systemic review of provocation studies. J Allergy Clin Immunol. 2006;118:1257–1264
  30. Bell IR, Schwartz GE, Baldwin CM, Hardin EE, Klimas NG, Kline JP, et al. Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures. Environ Health Perspect. 1997;105:457–466

PII: S0022-510X(09)00845-4

doi: 10.1016/j.jns.2009.09.003

Journal of the Neurological Sciences
Volume 287, Issue 1 , Pages 72-78 , 15 December 2009