APOE ε4 is a high-risk factor for Alzheimer's disease in the Mongolian population

Huriletemuer,; Wang, Binbin; Wang, Jing; Wang, Guan; Zhang, Chunyu; Zhao, Shigang; Zhou, Sirui; Ma, Xu; Wang, De Sheng

doi:10.1016/j.jns.2009.08.058

« Previous Next »Journal of the Neurological Sciences
Volume 288, Issue 1 , Pages 167-169, 15 January 2010

APOE ε4 is a high-risk factor for Alzheimer's disease in the Mongolian population

Huriletemuer
- Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China
- Department of Neurology, The First Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, China
- These authors contributed equally to this work.
Binbin Wang
- National Research Institute for Family Planning, Beijing, 100081, China
- These authors contributed equally to this work.
Jing Wang
- National Research Institute for Family Planning, Beijing, 100081, China
- Graduate School, Peking Union Medical College, Beijing, China
Guan Wang
- Neurosurgery, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin China
Chunyu Zhang
- Department of Neurology, The First Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, China
Shigang Zhao
- Department of Neurology, The First Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, China
Sirui Zhou
- National Research Institute for Family Planning, Beijing, 100081, China
- Graduate School, Peking Union Medical College, Beijing, China
Xu Ma
- National Research Institute for Family Planning, Beijing, 100081, China
- World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
- Corresponding authors. Xu Ma is to be contacted at Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China. Tel.: +86 10 62176870; fax: +86 10 62179151. Wang, Department of Neurology, The First Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, China.
De Sheng Wang
- Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China
- Corresponding authors. Xu Ma is to be contacted at Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China. Tel.: +86 10 62176870; fax: +86 10 62179151. Wang, Department of Neurology, The First Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, China.

Received 10 May 2009; received in revised form 26 August 2009; accepted 28 August 2009. published online 12 October 2009.

Abstract

To determine the relationship between apolipoprotein E (APOE) ε4 and sporadic Alzheimer's disease (SAD) in the Mongolian population in China, we examined 106 Mongolian SAD patients in China and 100 Mongolian healthy controls. All subjects were genotyped for APOE.

The odds ratio (OR) for developing SAD was significantly increased in carriers of the APOE ε4 allele compared with APOE ε4 non-carriers (χ²=5.59, df=1, P=0.018, OR=1.84, 95% CI 1.02–3.31).

Our findings suggested that APOE ε4 is a high-risk factor for AD in the Mongolian population in China. The present study is the first to establish the relationship between APOE ε4 and SAD in the Mongolian population.

Keywords: Alzheimer's disease, Apolipoprotein E, Mongolian