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Journal of the Neurological Sciences
Volume 283, Issue 1
, Pages 199-206
, 15 August 2009
The effect of acetyl-L-carnitine and R-α-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease
References
- . Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis. Neurobiol Aging. 2000;21:331–342
- . Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res Brain Res Rev. 2000;34:119–136
- Cerebrovascular pathology contributes to the heterogeneity of Alzheimer's disease. J Alzheimers Dis. 1998;1:119–134
- . Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord. 1999;13(Suppl 3):S115–S123
- . The blood–brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann N Y Acad Sci. 1999;893:113–125
- . Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622–630
- . Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E. Curr Opin Struct Biol. 1994;4:507–515
- . Apolipoprotein E polymorphism and Alzheimer's disease. Lancet. 1993;342:697–699
- A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest. 1989;83:1015–1031
- Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:9649–9653
- Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2000;97:2892–2897
- Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med. 2001;7:833–839
- Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol. 1997;151:1371–1377
- . M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice. J Neurochem. 1998;70:1991–1997
- Genis I, Michaelson DM. Hyperphosphorylation of tau in apolipoprotein E-deficient mice. In: al. Fe, editor. Progress in Alzheimer's and Parkinson's diseases. New York: Plenum Press; 1998. p. 251–256.
- . Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?. Ann N Y Acad Sci. 1997;826:128–146
- . Impairment of the blood–nerve and blood–brain barriers in apolipoprotein E knockout mice. Exp Neurol. 2001;169:13–22
- Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease meta analysis consortium. jAMA. 1997;278:1349–1356
- . Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 2002;99:2234–2239
- Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 1999;96:15233–15238
- Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits. Exp Mol Pathol. 2001;71:40–54
- . Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotox Res. 2003;5:491–504
- The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathol. 2002;12:21–35
- . Clinical studies of cerebral blood flow in Alzheimer's disease. Ann N Y Acad Sci. 1997;826:254–262
- . Longitudinal studies of regional cerebral metabolism in Alzheimer's disease. Neurology. 1988;38:909–912
- . Cholesterol homeostasis and the pathophysiology of Alzheimer's disease. Expert Rev Neurother. 2004;4:823–829
- . Vascular basis of Alzheimer's pathogenesis. Ann N Y Acad Sci. 2002;977:196–215
- . Alzheimer's disease: how does it start?. J Alzheimers Dis. 2002;4:497–512
- . Alzheimer disease as a vascular disorder: nosological evidence. Stroke. 2002;33:1152–1162
- A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005;25:3032–3040
- Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease. J Neurol Sci. 2005;229–230:285–292
- . Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET. Implications for Alzheimer's disease. Brain. 1999;122(Pt 8):1519–1531
- . Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol. 1995;38:357–366
- Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002;977:45–64
- . Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 1997;23:134–147
- . Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proc Natl Acad Sci U S A. 2001;98:3334–3339
- Localized cerebral blood flow reductions in patients with heart failure: a study using 99mTc-HMPAO SPECT. J Neuroimaging. 2005;15:150–156
- Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurol Res. 2003;25:665–674
- Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Neurotox Res. 2006;10:43–56
- Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002;99:2356–2361
- Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med. 2009;13:320–333[Epub ahead of print, Mar 29, 2008]
- . Computational study on use of single-point analysis method for quantitating local cerebral blood flow in mice. Adv Exp Med Biol. 2005;566:99–104
- ApoE deficiency induces age-dependent brain hypoperfusion and neuronal-glial and microvascular damage in mice. ApoE deficiency induces hypoperfusion that initiate age-dependent decreases in cerebral blood flow and microvessels lesions. 2007;4(Suppl 1):182
- . Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp Brain Res. 1985;58:11–28
- . Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11:47–60
- . Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci U S A. 2002;99:1876–1881
- . Isolation of an internal clock. J Exp Psychol Anim Behav Process. 1981;7:242–268
- Mitochondrial abnormalities in Alzheimer's disease. J Neurosci. 2001;21:3017–3023
- . Pathobiology of familial hypercholesterolemic atherosclerosis. J Submicrosc Cytol Pathol. 2004;36:225–240
- . Role of vascular hypoperfusion-induced oxidative stress and mitochondrial failure in the pathogenesis of Alzheimer disease. Neurotox Res. 2003;5:385–390
- . Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion. 2004;4:649–663
- Causes, early detection, treatment, models, prevention, risk factors. 2002;[cited; Available from: http://www.alz.org/Researchers/RGP/Biological.htm
- . Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103:5644–5651
- Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?. Free Radic Biol Med. 2002;33:1475–1479
- . Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes. J Cereb Blood Flow Metab. 2005;25:663–672
- The primary pathogenetic role of vascular hypoperfusion, and oxidative stress in Alzheimer disease. Atheroscler Suppl. 2007;8:105
- Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?. Neurol Res. 2004;26:547–553
- Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res. 2002;70:357–360
- Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol. 2007;66:525–532
- Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 2007;3
PII: S0022-510X(09)00491-2
doi: 10.1016/j.jns.2009.03.002
© 2009 Elsevier B.V. All rights reserved.
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Journal of the Neurological Sciences
Volume 283, Issue 1
, Pages 199-206
, 15 August 2009
