Journal of the Neurological Sciences
Volume 283, Issue 1 , Pages 195-198 , 15 August 2009

Brains of apolipoprotein E deficient mice fed vitamin E deficient diets show alteration in handling alpha tocopherol injected into the cerebral ventricles

  • Govind T. Vatassery

      Affiliations

    • Research Service and the GRECC Program, V.A. Medical Center, Minneapolis, Minnesota, USA
    • Department of Psychiatry and the Graduate Program in Neuroscience, University of Minnesota, Minneapolis 55455, USA
    • Corresponding Author InformationCorresponding author. Research Service (151), V.A. Medical Center, Minneapolis, Minnesota 55417, USA. Tel.: +1 612 467 2910; fax: +1 612 725 2084.
    • ,
  • W. Ed Smith

      Affiliations

    • Research Service and the GRECC Program, V.A. Medical Center, Minneapolis, Minnesota, USA
    • ,
  • Hung T. Quach

      Affiliations

    • Research Service and the GRECC Program, V.A. Medical Center, Minneapolis, Minnesota, USA

References 

  1. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921–923
  2. Farrer LA, Cupples A, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease. J Am Med Assoc. 1997;278:1349–1356
  3. Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Nat Acad Sci (USA). 2006;103:5644–5651
  4. Pratico D, Rokach J, Tangirala RK. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. J Neurochem. 1999;73:736–741
  5. Shea TB, Rogers E, Ashline D, Ortiz D, Sheu MS. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Rad Biol Med. 2002;33:1115–1120
  6. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al. A controlled trial of selegiline, alpha tocopherol, or both as treatment for Alzheimer's disease. New Engl J Med. 1997;336:1216–1222
  7. Vatassery GT, Lam C, Smith WE, Quach HT. Apolipoprotein E exerts selective and differential control over vitamin E concentrations in different areas of mammalian brain. J Neurosci Res. 2006;84:1335–1342
  8. Vatassery GT, Quach HT, Smith WE, Santacruz KS, Roy S. Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles. Biochim Biophys Acta. Jul 2007;1772(7):797–803
  9. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939–1951
  10. Franklin KJ, Paxinos G. The mouse brain in stereotaxic coordinates. New York: Academic Press; 1997;
  11. Glowinski J, Iversen LL. Regional studies of catecholamines in the rat brain. J Neurochem. 1966;13:655–669
  12. Vatassery GT, Smith WE, Quach HT. A liquid chromatographic method for the simultaneous determination of alpha tocopherol and tocopherolquinone in human red blood cells and other biological samples where tocopherol is easily oxidized during sample treatment. Anal Biochem. 1993;214:426–430
  13. Markwell MAK, Haas SM, Bieber LL, Tolbert NE. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 1978;87:206–210
  14. Liu JF, Huang CJ. Dietary oxidized frying oil enhances tissue alpha-tocopherol depletion and radioisotope tracer excretion in vitamin E-deficient rats. J Nutr. Sep 1996;126(9):2227–2235
  15. Vatassery GT, Quach HT, Smith WE, Kuskowski M. Deletion of apolipoprotein E gene modifies the rate of depletion of alpha tocopherol (vitamin E) from mice brains. Biochim Biophys Acta. Jun 2008;1782(6):414–420
  16. Roheim PS, Carey M, Forte T, Vega GL. Apolipoproteins in human cerebrospinal fluid. Proc Natl Acad Sci (USA). 1979;76:4646–4649
  17. Mardones P, Strobel P, Miranda S, Leighton F, Quinones V, Amigo L, et al. Alpha tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-B1)-deficient mice. J Nutr. 2002;132:443–449

PII: S0022-510X(09)00437-7

doi: 10.1016/j.jns.2009.02.350

Journal of the Neurological Sciences
Volume 283, Issue 1 , Pages 195-198 , 15 August 2009

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