Journal of the Neurological Sciences
Volume 283, Issue 1 , Pages 137-138 , 15 August 2009

Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients

  • Małgorzata Bednarska- Makaruk

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland
    • Corresponding Author InformationCorresponding author. Institute of Psychiatry and Neurology, Department of Genetics, 02-957 Warsaw, Poland, ul. Sobieskiego 9. Fax: +48 22 6589169.
    • ,
  • Maria Rodo

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Ałła Graban

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Wanda Łojkowska

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Anna Bochyńska

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Danuta Ryglewicz

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Hanna Wehr

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

References 

  1. Maggi E, Belazzi R, Gazo A, Seccia M, Bellomo G. Autoantibodies against oxidatively-modified LDL in uremic patients undergoing dialysis. Kidney Int. 1994;46:869–876
  2. Steinerova A, Racek J, Stożicky F, Zima T, Fialova L, Lapin A. Antibodies against oxidized LDL — theory and clinical use. Phyiol Rev. 2001;50:131–141
  3. Shoji T, Nishizawa Y, Fukumoto M, Shimamura K, Kimura J, Kanda H. Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects. Atherosclerosis. 2000;148:171–177
  4. Karabinos I, Kouloris S. Increased serum titers of autoantibodies against oxidized LDL cholesterol in young healthy adults. Atherosclerosis. 2007;192:448–450
  5. Tinahones FJ, Gomez-Zumaquero JM, Garrido-Sanchez L, Garcia-Fuentes E, Rojo-Martinez G, Esteva I, et al. Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population. J Lip Res. 2005;46:452–457
  6. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha1. J Lip Res. 1990;1:545–546
  7. Wehr H, Bednarska-Makaruk M, Graban A, Kunicki P, Łojkowska W, Rodo M, et al. Apolipoprotein E polymorphism and low density lipoprotein (LDL) oxidation in patients with dementia. Folia Neuropathol. 2003;41:65–68
  8. Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 1989;6:61–75
  9. Miyata M, Smith JD. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nature Genet. 1996;14:56–61
  10. Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Shara N, et al. Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease. Neurology. 2000;54:3192321
  11. Nikkila M, Pitkajarvi T, Koivula T, olakivi T, Lehtimaki T, Laippala P, et al. Women have a larger and less atherogenic low density lipoprotein particle size than men. Atheroclerosis. 1996;118:181–190
  12. Akanji AO, Suresh CG, Fatania HR, Al-Radwan R, Zubaid M. Association of apolipoprotein E polymorphism with low-density lipoprotein size and subfraction profiles in Arab patients with coronary heart disease. Metabolism. 2007;6:484–490
  13. Tribble DL, Holl LG, Wood PD, Krauss RM. Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing sensitivity and particle size. Atherosclerosis. 1992;93:189–199
  14. Hansel B, Kontush A, Bonnefont-Rousselot D, Bruckert E, Chapman MJ. Alterations in lipoprotein defense against oxidative stress in metabolic syndrome. Curr Atheroscl Rep. 2006;8:501–509
  15. Chen GC, Liu W, Duchateau P, Alart J, Hamilton RL, Mendel CM, et al. Conformational differences in human apolipoprotein B-100 among subspecies of low density lipoproteins (LDL). Association of altered proteolytic accessibility with decreased receptor binding of LDL subspecies from hypertriglyceridemic subjects. J Biol Chem. 1994;269:29121–29128
  16. Lund-Katz S, Lapiaud PM, Phillips MC, Chapman MJ. Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction. Biochemistry. 1998;37(12867):12874
  17. Rontu R, Ojala P, Hervonen A, Goebeler S, Kahunen PJ, Nikkila M, et al. Apolipoprotein E genotype is related to plasma levels of C-reactive protein and longevity in nonagenarians. Clin Endocrinol. 2006;64:265–270
  18. Maerz W, Scharnagl H, Hoffmann MM, Boehm BO, Winkelman BR. The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study. Eur Heart J. 2004;25:2109–2119

PII: S0022-510X(09)00425-0

doi: 10.1016/j.jns.2009.02.345

Journal of the Neurological Sciences
Volume 283, Issue 1 , Pages 137-138 , 15 August 2009

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