Journal of the Neurological Sciences
Volume 283, Issue 1 , Pages 137-138, 15 August 2009

Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients

  • Małgorzata Bednarska- Makaruk

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland
    • Corresponding Author InformationCorresponding author. Institute of Psychiatry and Neurology, Department of Genetics, 02-957 Warsaw, Poland, ul. Sobieskiego 9. Fax: +48 22 6589169.
    • ,
  • Maria Rodo

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Ałła Graban

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Wanda Łojkowska

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Anna Bochyńska

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Danuta Ryglewicz

      Affiliations

    • First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Hanna Wehr

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland

published online 23 March 2009.

Abstract 

In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of ε2 allele and less frequent in the carriers of ε4 allele.

Keywords: Anti-oxLDL antibodies, Apo E polymorphism

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PII: S0022-510X(09)00425-0

doi:10.1016/j.jns.2009.02.345

Journal of the Neurological Sciences
Volume 283, Issue 1 , Pages 137-138, 15 August 2009

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