Journal of the Neurological Sciences
Volume 280, Issue 1 , Pages 98-100 , 15 May 2009

The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity?

  • Sven Jarius

      Affiliations

    • Division of Molecular Neuroimmunology, Department of Neurology, Ruprecht Karl University, Heidelberg, Germany
    • ,
  • Peter Eichhorn

      Affiliations

    • Department of Clinical Chemistry, Ludwig Maximilians University, Munich, Germany
    • ,
  • Christian Jacobi

      Affiliations

    • Division of Molecular Neuroimmunology, Department of Neurology, Ruprecht Karl University, Heidelberg, Germany
    • ,
  • Brigitte Wildemann

      Affiliations

    • Division of Molecular Neuroimmunology, Department of Neurology, Ruprecht Karl University, Heidelberg, Germany
    • ,
  • Manfred Wick

      Affiliations

    • Department of Clinical Chemistry, Ludwig Maximilians University, Munich, Germany
    • ,
  • Raymond Voltz

      Affiliations

    • Department of Palliative Medicine, University of Cologne, Cologne, Germany
    • Corresponding Author InformationCorresponding author. Department of Palliative Medicine, University of Cologne, D-50924 Cologne, Germany. Tel.: +49 221478 3361; fax: +49 221478 87579.

Received 14 March 2008 ,Revised 22 July 2008 ,Accepted 6 August 2008.

References 

  1. Sindic CJ, Monteyne P, Laterre EC. The intrathecal synthesis of virus-specific oligoclonal IgG in multiple sclerosis. J Neuroimmunol. 1994;54:75–80
  2. Reiber H, Ungefehr S, Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult Scler. 1998;4:111–117
  3. Meinl E, Krumbholz M, Hohlfeld R. B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation. Ann Neurol. 2006;59:880–892
  4. Felgenhauer K, Reiber H. The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system. Clin Investig. 1992;70:28–37
  5. Frederiksen JL, Sindic CJ. Intrathecal synthesis of virus-specific oligoclonal IgG, and of free kappa and free lambda oligoclonal bands in acute monosymptomatic optic neuritis. Comparison with brain MRI. Mult Scler. 1998;4:22–26
  6. Graef IT, Henze T, Reiber H. Polyspecific immune reaction in the central nervous system in autoimmune diseases with CNS involvement. Z Arztl Fortbild (Jena). 1994;88:587–591
  7. Felgenhauer K, Schadlich HJ, Nekic M, Ackermann R. Cerebrospinal fluid virus antibodies. A diagnostic indicator for multiple sclerosis?. J Neurol Sci. 1985;71:291–299
  8. Voltz R. Paraneoplastic neurological syndromes: an update on diagnosis, pathogenesis, and therapy. Lancet Neurol. 2002;1:294–305
  9. Dalmau J, Rosenfeld MR. Paraneoplastic syndromes of the CNS. Lancet Neurol. 2008;7:327–340
  10. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol. 2007;6:805–815
  11. Jarius S, Franciotta D, Bergamaschi R, Rauer S, Wandinger KP, Petereit H, et al. Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica. J Neurol Neurosurg Psychiatry. 2008 Oct;79(10):1134–1136
  12. Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry. 2004;75:1135–1140
  13. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121–127
  14. Reiber H. Cerebrospinal fluid—physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases. Mult Scler. 1998;4:99–107
  15. Bednarova J, Stourac P, Adam P. Relevance of immunological variables in neuroborreliosis and multiple sclerosis. Acta Neurol Scand. 2005;112:97–102
  16. Puccioni-Sohler M, Kitze B, Felgenhauer K, Graef IT, Lange P, Novis S, et al. The value of CSF analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis. Arq Neuropsiquiatr. 1995;53:760–765
  17. Walsh MJ, Tourtellotte WW. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J Exp Med. 1986;163:41–53
  18. Robinson-Agramonte M, Reiber H, Cabrera-Gomez JA, Galvizu R. Intrathecal polyspecific immune response to neurotropic viruses in multiple sclerosis: a comparative report from Cuban patients. Acta Neurol Scand. 2007;115:312–318
  19. Godec MS, Asher DM, Murray RS, Shin ML, Greenham LW, Gibbs CJ, et al. Absence of measles, mumps, and rubella viral genomic sequences from multiple sclerosis brain tissue by polymerase chain reaction. Ann Neurol. 1992;32:401–404

PII: S0022-510X(08)00380-8

doi: 10.1016/j.jns.2008.08.002

Journal of the Neurological Sciences
Volume 280, Issue 1 , Pages 98-100 , 15 May 2009

Article Tools

* Image Usage & Resolution