Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 97-99 , 15 January 2008

Interaction between CD14 and LXRβ genes modulates Alzheimer's disease risk

  • Eloy Rodríguez-Rodríguez

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • ,
  • Pascual Sánchez-Juan

      Affiliations

    • Fundación “Marqués de Valdecilla”, IFIMAV, Santander, Spain
    • ,
  • Ignacio Mateo

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • ,
  • Jon Infante

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • ,
  • Coro Sánchez-Quintana

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • ,
  • Inés García-Gorostiaga

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • ,
  • José Berciano

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • ,
  • Onofre Combarros

      Affiliations

    • Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
    • Corresponding Author InformationCorresponding author. Neurology Service, University Hospital “Marqués de Valdecilla”, 39008 Santander, Spain. Tel.: +34 942 202507; fax: +34 942 202655.

Received 21 May 2007 ,Revised 4 July 2007 ,Accepted 1 August 2007.

References 

  1. Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease: a double-edged sword. Neuron. 2002;35:419–432
  2. Nguyen MD, Julien JP, Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration?. Nat Rev Neurosci. 2002;3:216–227
  3. Liu Y, Walter S, Stagi M, Cherny D, Letiembre M, Schulz-Schaeffer W, et al. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain. 2005;128:1778–1789
  4. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9:213–219
  5. Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116:607–614
  6. Zhang-Gandhi CX, Drew PD. Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes. J Neuroimmunol. 2007;183:50–59
  7. McKhaan G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34:934–944
  8. Combarros O, Infante J, Rodríguez E, Llorca J, Peña N, Fernández-Viadero C, et al. CD14 receptor polymorphism and Alzheimer's disease risk. Neurosci Lett. 2005;380:193–196
  9. Fassbender K, Walter S, Kuhl S, Landmann R, Ishii K, Bertsch T, et al. The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J. 2004;18:203–205
  10. Hubacek JA, Pit'ha J, Skodová Z, Stanek V, Poledne R. C(−260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation. 1999;99:3218–3220
  11. Koenig W, Khuseyinova N, Hoffmann MM, März W, Fröhlich M, Hoffmeister A, et al. CD14 C(−260)→T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease. J Am Coll Cardiol. 2002;40:34–42
  12. Minoretti P, Gazzaruso C, Di Vito C, Emanuele E, Bianchi M, Coen E, et al. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Neurosci Lett. 2006;391:147–149
  13. Adighibe O, Arepalli S, Duckworth J, Hardy J, Wavrant-De Vrieze F. Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease. Neurobiol Aging. 2006;27:1431–1434

PII: S0022-510X(07)00525-4

doi: 10.1016/j.jns.2007.08.001

Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 97-99 , 15 January 2008

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