Interaction between CD14 and LXRβ genes modulates Alzheimer's disease risk

Rodríguez-Rodríguez, Eloy; Sánchez-Juan, Pascual; Mateo, Ignacio; Infante, Jon; Sánchez-Quintana, Coro; García-Gorostiaga, Inés; Berciano, José; Combarros, Onofre

doi:10.1016/j.jns.2007.08.001

« Previous Next »Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 97-99, 15 January 2008

Interaction between CD14 and LXRβ genes modulates Alzheimer's disease risk

Eloy Rodríguez-Rodríguez
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
Pascual Sánchez-Juan
- Fundación “Marqués de Valdecilla”, IFIMAV, Santander, Spain
Ignacio Mateo
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
Jon Infante
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
Coro Sánchez-Quintana
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
Inés García-Gorostiaga
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
José Berciano
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
Onofre Combarros
- Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University Hospital “Marqués de Valdecilla” (University of Cantabria), Santander, Spain
- Corresponding author. Neurology Service, University Hospital “Marqués de Valdecilla”, 39008 Santander, Spain. Tel.: +34 942 202507; fax: +34 942 202655.

Received 21 May 2007; received in revised form 4 July 2007; accepted 1 August 2007.

Abstract

A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer's disease (AD). CD14 and LXRβ are receptors involved in the regulation of inflammatory responses of microglia in response to bacterial infection or lipopolysaccharide stimulation. In a case–control study in 266 AD patients and 273 healthy controls, we examined whether the combined gene effects between CD14 (−260) polymorphism and LXRβ (intron 5) polymorphism might be responsible for susceptibility to AD. Subjects carrying both the CD14 (−260) C/C and the LXRβ (intron 5) G/G genotypes had a six times lower risk of developing AD than subjects without these risk genotypes (OR 0.16, 95% CI 0.04–0.67, p=0.01). These data support a role for innate immune response genes in risk for AD.