Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 27-33 , 15 January 2008

Quantitative analysis of brain perfusion SPECT in Alzheimer's disease using a fully automated regional cerebral blood flow quantification software, 3DSRT

  • Seiju Kobayashi

      Affiliations

    • Department of Psychiatry, Sunagawa City Medical Center, Japan
    • ,
  • Masaru Tateno

      Affiliations

    • Department of Psychiatry, Sunagawa City Medical Center, Japan
    • Department of Neuropsychiatry, Sapporo Medical University, Sapporo, Japan
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Sunagawa City Medical Center, 1-1,West 4, North 2, Sunagawa, Hokkaido, 0730196, Japan. Tel.: +81 125 54 2131; fax: +81 125 54 0101.
    • ,
  • Kumiko Utsumi

      Affiliations

    • Department of Psychiatry, Sunagawa City Medical Center, Japan
    • ,
  • Akira Takahashi

      Affiliations

    • Departments of Neurology and Neurosurgery, Sunagawa City Medical Center, Japan
    • ,
  • Masaki Saitoh

      Affiliations

    • Department of Cerebrovascular Disease, Cerebrovascular Center and Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan
    • ,
  • Hidetoshi Morii

      Affiliations

    • Department of Radiology, Sunagawa City Medical Center, Japan
    • ,
  • Kazuki Fujii

      Affiliations

    • Department of Radiology, Sunagawa City Medical Center, Japan
    • ,
  • Masatoshi Teraoka

      Affiliations

    • Department of Psychiatry, Sunagawa City Medical Center, Japan

Received 9 November 2006 ,Revised 9 March 2007 ,Accepted 11 July 2007.

References 

  1. Aronson MK, Ooi WL, Geva DL, Masur D, Blau A, Frishman W. Dementia. Age-dependent incidence, prevalence, and mortality in the old old. Arch Intern Med. 1991;151:989–992
  2. Schott JM, Price SL, Frost C, Whitwell JL, Rossor MN, Fox NC. Measuring atrophy in Alzheimer disease: a serial MRI study over 6 and 12 months. Neurology. 2005;65:119–124
  3. Tam CW, Burton EJ, McKeith IG, Burn DJ, O'Brien JT. Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology. 2005;64:861–865
  4. van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM. Hippocampal atrophy in Alzheimer disease: age matters. Neurology. 2006;66:236–238
  5. Friston KJ. Analyzing brain images: principles and overview. In:  Frackowiak RSJ,  Friston KJ,  Frith CD, et al. editor. Human Brain Function. San Diego: Academic Press; 1997;p. 25–41
  6. Minoshima S, Koeppe RA, Frey KA, Kuhl DE. Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med. 1994;35:1528–1537
  7. Takeuchi R, Yonekura Y, Takeda SK, Fujita K, Konishi J. Fully automated quantification of regional cerebral blood flow with three-dimensional stereotaxic region of interest template: validation using magnetic resonance imaging-technical note. Neurol Med Chir (Tokyo). 2003;43:153–162
  8. Takeuchi R, Matsuda H, Yoshioka K, Yonekura Y. Cerebral blood flow SPET in transient global amnesia with automated ROI analysis by 3DSRT. Eur J Nucl Med Mol Imaging. 2004;31:578–589
  9. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  10. Lojkowska W, Ryglewicz D, Jedrzejczak T, Minc S, Jakubowska T, Jarosz H, et al. The effect of cholinesterase inhibitors on the regional blood flow in patients with Alzheimer's disease and vascular dementia. J Neurol Sci. 2003;216:119–126
  11. Tanaka M, Namiki C, Thuy DH, Yoshida H, Kawasaki K, Hashikawa K, et al. Prediction of psychiatric response to donepezil in patients with mild to moderate Alzheimer's disease. J Neurol Sci. 2004;225:135–141
  12. Shimizu S, Hanyu H, Iwamoto T, Koizumi K, Abe K. SPECT follow-up study of cerebral blood flow changes during Donepezil therapy in patients with Alzheimer's disease. J Neuroimaging. 2006;16:16–23
  13. Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. Noninvasive measurements of regional cerebral blood flow using technetium-99 m hexamethylpropylene amine oxime. Eur J Nucl Med. 1993;20:391–401
  14. Matsuda H, Yagishita A, Tsuji S, Hisada K. A quantitative approach to technetium-99 m ethyl cysteinate dimer: a comparison with technetium-99 m hexamethylpropylene amine oxime. Eur J Nucl Med. 1995;22:633–637
  15. Lassen NA, Andersen AR, Friberg L, Paulson OB. The retention of [99mTc]-d,l-HM-PAO in the human brain after intracarotid bolus injection: a kinetic analysis. J Cereb Blood Flow Metab. 1988;8:S13–S22
  16. Friberg L, Andersen AR, Lassen NA, Holm S, Dam M. Retention of 99mTc-bicisate in the human brain after intracarotid injection. J Cereb Blood Flow Metab. 1994;14(Suppl 1):S19–S27
  17. Matsuda H, Kitayama N, Ohnishi T, Asada T, Nakano S, Sakamoto S, et al. Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer's disease. J Nucl Med. 2002;43:304–311
  18. Takeuchi R, Matsuda H, Yonekura Y, Sakahara H, Konishi J. Noninvasive quantitative measurements of regional cerebral blood flow using technetium-99m-l,l-ECD SPECT activated with acetazolamide: quantification analysis by equal-volume-split 99mTc-ECD consecutive SPECT method. J Cereb Blood Flow Metab. 1997;17:1020–1032
  19. Takeuchi R, Yonekura Y, Matsuda H, Konishi J. Usefulness of a three-dimensional stereotaxic ROI template on anatomically standardised 99mTc-ECD SPET. Eur J Nucl Med Mol Imaging. 2002;29:331–341
  20. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme; 1988;
  21. Papez JW. A proposed mechanism for emotion. Arch Neurol Psychiatry. 1937;38:725–743
  22. Shibata H. Topographic organization of subcortical projections to the anterior thalamic nuclei in the rat. J Comp Neurol. 1992;323:117–127
  23. Amaral DG, Witter MP. Hippocampal formation. In:  Paxinos G editors. The rat nervous system. 2nd ed.. London: Academic Press; 1995;p. 443–493
  24. Van Groen T, Wyss JM. Projections from the anterodorsal and anteroventral nucleus of the thalamus to the limbic cortex in the rat. J Comp Neurol. 1995;358:584–604
  25. LeDoux JE. Emotion, memory and the brain. Sci Am. 1994;270:50–57
  26. Sutherland RJ, Whishaw IQ, Kolb B. Contributions of cingulate cortex to two forms of spatial learning and memory. J Neurosci. 1988;8:1863–1872
  27. Sziklas V, Petrides M. Memory impairments following lesions to the mammillary region of the rat. Eur J Neurosci. 1993;5:525–540
  28. Aggleton JP, Brown MW. Episodic memory, amnesia, and the hippocampal–anterior thalamic axis. Behav Brain Sci. 1999;22:425–444
  29. Vertes RP, Albo Z, Viana Di Prisco G. Theta-rhythmically firing neurons in the anterior thalamus: implications for mnemonic functions of Papez's circuit. Neuroscience. 2001;104:619–625
  30. Cabeza R, Dolcos F, Graham R, Nyberg L. Similarities and differences in the neural correlates of episodic memory retrieval and working memory. NeuroImage. 2002;16:317–330
  31. Baleydier C, Mauguiere F. The duality of the cingulate gyrus in monkey. Neuroanatomical study and functional hypothesis. Brain. 1980;103:525–554
  32. Meguro K, Blaizot X, Kondoh Y, Le Mestric C, Baron JC, Chavoix C. Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET. Implications for Alzheimer's disease. Brain. 1999;122:1519–1531
  33. Mosconi L, Pupi A, De Cristofaro MT, Fayyaz M, Sorbi S, Herholz K. Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease. J Nucl Med. 2004;45:382–392

PII: S0022-510X(07)00482-0

doi: 10.1016/j.jns.2007.07.015

Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 27-33 , 15 January 2008

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