Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 9-17 , 15 January 2008

Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: Preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients

  • Ádám Vas

      Affiliations

    • Chemical Works of Gedeon Richter Ltd., Gyomroi ut 19/21, H-1103 Budapest, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36 1 431 4200.
    • ,
  • Yevgeni Shchukin

      Affiliations

    • Karolinska Institute, Psychiatry Section, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden
    • ,
  • Virginija D. Karrenbauer

      Affiliations

    • Neurotec, Section for Neurology, Huddinge University Hospital, Karolinska Institute, S-14186 Huddinge, Sweden
    • ,
  • Zsolt Cselényi

      Affiliations

    • Karolinska Institute, Psychiatry Section, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden
    • ,
  • Kosta Kostulas

      Affiliations

    • Neurotec, Section for Neurology, Huddinge University Hospital, Karolinska Institute, S-14186 Huddinge, Sweden
    • ,
  • Jan Hillert

      Affiliations

    • Neurotec, Section for Neurology, Huddinge University Hospital, Karolinska Institute, S-14186 Huddinge, Sweden
    • ,
  • Ivanka Savic

      Affiliations

    • Neurotec, Section for Neurology, Huddinge University Hospital, Karolinska Institute, S-14186 Huddinge, Sweden
    • ,
  • Akihiro Takano

      Affiliations

    • Karolinska Institute, Psychiatry Section, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden
    • ,
  • Christer Halldin

      Affiliations

    • Karolinska Institute, Psychiatry Section, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden
    • ,
  • Balázs Gulyás

      Affiliations

    • Karolinska Institute, Psychiatry Section, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden

Received 12 October 2006 ,Revised 5 July 2007 ,Accepted 9 July 2007.

References 

  1. Junck L, Olson JM, Ciliax BJ, Koeppe RA, Watkins GL, Jewett DM, et al. PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. Ann Neurol. Dec 1989;26(6):752–758
  2. Maeda J, Suhara T, Zhang MR, Okauchi T, Yasuno F, Ikoma Y, et al. Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain. Synapse. June 15 2004;52(4):283–291
  3. Gulyás B, Halldin C, Vas A, Banati RB, Schukin E, Finnema , et al. [11C]Vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies. J Neurol Sci. 2005;229-230:219–223
  4. Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, et al. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res. 1997;50:345–353
  5. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkmeimer F, Heppner F, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis. Quantitative in vivo imaging of microglia as a measure of disease activity. Brain. 2000;123:2321–2337
  6. Debruyne JC, Versijpt J, Van Laere KJ, De Vos F, Keppens J, Strijckmans K, et al. PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol. 2003;10:257–264
  7. Bonoczk P, Gulyás B, Adam-Vizi V, Nemes A, Kárpáti E, Kiss B, et al. Role of sodium channel inhibition in neuroprotection: effect of vinpocetine. Brain Res Bull. 2000;53:245–254
  8. Vas A, Gulyás B. Eburnamine derivatives and the brain. Med Res Rev. 2005;25(6):737–757
  9. Gulyás B, Halldin C, Karlsson P, Chou Y-H, Swahn C-G, Bönöczk P, et al. Brain uptake and plasma metabolism of [11C]vinpocetine: a preliminary PET study in Cynomolgous monkey. J Neuroimaging. 1999;9:217–222
  10. Gulyás B, Halldin C, Sandell J, Swahn C-G, Bönöczk P, Kiss B, et al. PET studies on the uptake and regional distribution of [11C]vinpocetine in human subjects. Acta Neurol Scand. 2002;106:325–332
  11. Gulyás B, Halldin C, Sóvágó J, Sandell J, Cselényi Zs, Vas A, et al. Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine. Eur J Nucl Med. 2002;29:1031–1038
  12. Talairach J, Torunoux P. Co-planar stereotaxic atlas of the human brain. New York, Stuttgart: Thieme Verlag; 1988;
  13. Sandell J, Langer O, Larsen P, Dollé F, Vaufrey F, Demphel S, et al. Improved specific radioactivity of the PET radioligand [11C]FLB 457 by use of the GE medical systems. J Labell Compd Radiopharm. 2000;43:331–338
  14. Cremer JE, Hume SP, Cullen BM, Myers R, Manjil LG, Turton DR, et al. The distribution of radioactivity in brains of rats given [N-methyl-11C]PK 11195 in vivo after induction of a cortical ischaemic lesion. Nucl Med Biol. 1992;9:159–166
  15. Wienhard K, Dahlblom M, Eriksson L, Michel C, Bruckbauer T, Pietrzyk U, et al. The ECAT EXACT HR: performance of a new high resolution positron scanner. J Comput Assist Tomogr. 1994;18:110–118
  16. Greitz T, Bergström M, Boethius J, Kingsley D, Ribbet T. Head fixation device for integration of radiodiagnostic and radiotherapeutic processes. Neuroradiology. 1980;19:1–6
  17. Bergström M, Boethius J, Eriksson L, Greitz T, Ribbe T, Widen L. Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr. 1981;198:136–141
  18. Roland PE, Graufelds CJ, Wählin J, Ingelman L, Andersson M, Ledberg A, et al. Human brain atlas: for high-resolution functional and anatomical mapping. Hum Brain Mapp. 1994;1:173–184
  19. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 1996;16:834–840
  20. Kropholler MA, Boellard R, van Berckel B, Schuitemaker A, Kloet R, Lubberink M, et al. Evaluation of reference regions for (R)-[11C]PK11195 studies in Alzheimer's disease and mild cognitive impairment. J Cereb Blood Flow Metab. Apr 4 2007;[Electronic publication ehead of print]
  21. Kassiou M, Meikle SR, Banati RB. Ligands for peripheral benzodiazepine binding sites in glial cells. Brain Res Rev. 2005;48:207–210
  22. Wilms H, Claasen J, Röhl C, Sievers J, Deuschl G, Lucius R. Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro. Sci Dir Neurobiol Dis. 2003;14:417–424
  23. Chaki S, Funakoshi T, Yoshikawa R, Okuyama S, Okubo T, Nakazato A, et al. Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors. Eur J Pharmacol. 1999;371:197–204
  24. James ML, Fulton RR, Henderson DJ, Eberl S, Meikle SR, Thomson S, et al. Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand. Bioorg Med Chem. Nov 15 2005;13(22):6188–6194

PII: S0022-510X(07)00479-0

doi: 10.1016/j.jns.2007.07.018

Journal of the Neurological Sciences
Volume 264, Issue 1 , Pages 9-17 , 15 January 2008

Article Tools

* Image Usage & Resolution