Journal of the Neurological Sciences
Volume 238, Issue 1 , Pages 25-30 , 15 November 2005

The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice

  • S. Petri

      Affiliations

    • Department of Neurology, Medizinische Hochschule Hannover, D-30623, Hannover, Germany
    • Department of Neurology, Cornell University Medical College, New York, NY 10021, USA
    • Corresponding Author InformationCorresponding author. Department of Neurology, Cornell University Medical College, 525 East 68th Street, New York, NY 10021, USA. Tel.: +1 212 746 4567; fax: +1 212 746 4803.
    • ,
  • S. Schmalbach

      Affiliations

    • Department of Neurology, Medizinische Hochschule Hannover, D-30623, Hannover, Germany
    • ,
  • J. Grosskreutz

      Affiliations

    • Department of Neurology, Medizinische Hochschule Hannover, D-30623, Hannover, Germany
    • ,
  • K. Krampfl

      Affiliations

    • Department of Neurology, Medizinische Hochschule Hannover, D-30623, Hannover, Germany
    • ,
  • C. Grothe

      Affiliations

    • Department of Neuroanatomy, Medizinische Hochschule Hannover, D-30623, Hannover, Germany
    • ,
  • R. Dengler

      Affiliations

    • Department of Neurology, Medizinische Hochschule Hannover, D-30623, Hannover, Germany
    • ,
  • L. Van Den Bosch

      Affiliations

    • Laboratory of Neurobiology, KU Leuven, Campus Gasthuisberg, B-3000, Leuven, Belgium
    • ,
  • W. Robberecht

      Affiliations

    • Laboratory of Neurobiology, KU Leuven, Campus Gasthuisberg, B-3000, Leuven, Belgium
    • ,
  • J. Bufler

      Affiliations

    • Department of Neurology, Medizinische Hochschule Hannover, D-30623, Hannover, Germany

Received 15 April 2005 ,Revised 2 June 2005 ,Accepted 6 June 2005.

References 

  1. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993;362:59–62
  2. Gurney ME. Transgenic-mouse model of amyotrophic lateral sclerosis. N Engl J Med. 1994;331:1721–1722
  3. Couratier P, Hugon J, Sindou P, Vallat JM, Dumas M. Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Lancet. 1993;341:265–268
  4. Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve. 2002;26:438–458
  5. Rothstein JD. Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. Adv Neurol. 1995;68:7–20
  6. Enterzari-Taher M, Eisen A, Stewart H, Nakajima M. Abnormalities of cortical inhibitory neurons in amyotrophic lateral sclerosis. Muscle Nerve. 1997;20:65–71
  7. Lloyd CM, Richardson MP, Brooks DJ, Al Chalabi A, Leigh PN. Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C] flumazenil. Brain. 2000;123:2289–2296
  8. Petri S, Krampfl K, Hashemi F, Grothe C, Hori A, Dengler R, et al. Distribution of GABAA receptor mRNA in the motor cortex of ALS patients. J Neuropathol Exp Neurol. 2003;62:1041–1051
  9. Mohler H, Fritschy JM, Luscher B, Rudolph U, Benson J, Benke D. The GABAA receptors. From subunits to diverse functions. Ion Channels. 1996;4:89–113
  10. Wisden W, Gundlach AL, Barnard EA, Seeburg PH, Hunt SP. Distribution of GABAA receptor subunit mRNAs in rat lumbar spinal cord. Brain Res Mol Brain Res. 1991;10:179–183
  11. Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci. 1994;17:31–108
  12. Sommer B, Keinanen K, Verdoorn TA, Wisden W, Burnashev N, Herb A, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990;249:1580–1585
  13. Sommer B, Kohler M, Sprengel R, Seeburg PH. RNA editing in brain controls a determinant of ion flow in glutamate- gated channels. Cell. 1995;67:11–19
  14. Tolle TR, Berthele A, Zieglgansberger W, Seeburg PH, Wisden W. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci. 1993;13:5009–5028
  15. Furuyama T, Kiyama H, Sato K, Park HT, Maeno H, Takagi H, et al. Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Brain Res Mol Brain Res. 1993;8:141–151
  16. Tomiyama M, Rodriguez-Puertas R, Cortes R, Pazos A, Palacios JM, Mengod G. Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization. Neuroscience. 1996;75:901–915
  17. Tomiyama M, Rodriguez-Puertas R, Cortes R, Christnacher A, Sommer B, Pazos A, et al. Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. Synapse. 2002;45:245–249
  18. Virgo L, Samarasinghe S, De Belleroche J. Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord. Neuroreport. 1996;7:2507–2511
  19. Williams TL, Day NC, Ince PG, Kamboj RK, Shaw PJ. Calcium permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. Ann Neurol. 1997;42:200–207
  20. Heath PR, Tomkins J, Ince PG, Shaw PJ. Quantitative assessment of AMPA receptor mRNA in human spinal motor neurons isolated by laser capture microdissection. Neuroreport. 2002;13:1753–1757
  21. Kawahara Y, Kwak S, Sun H, Ito K, Hashida H, Aizawa H, et al. Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS. J Neurochem. 2003;85:680–689
  22. Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S. Glutamate receptors: RNA editing and death of motor neurons. Nature. 2004;427:801
  23. Rembach A, Turner BJ, Bruce S, Cheah IK, Scott RL, Lopes EC, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004;77:573–582

PII: S0022-510X(05)00223-6

doi: 10.1016/j.jns.2005.06.005

Journal of the Neurological Sciences
Volume 238, Issue 1 , Pages 25-30 , 15 November 2005

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