Journal of the Neurological Sciences
Volume 238, Issue 1 , Pages 19-24 , 15 November 2005

Reduced prefrontal N-acetylaspartate in stroke patients with apathy

  • Lidia Glodzik-Sobanska

      Affiliations

    • Center for Brain Health, NYU School of Medicine, 550 First Avenue, HN-400, New York, NY 10016-6481, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 263 7536; fax: +1 212 263 3270.
    • ,
  • Agnieszka Slowik

      Affiliations

    • Department of Neurology, Institute of Neurology, Jagiellonian University, Krakow, Poland
    • ,
  • Agnieszka Kieltyka

      Affiliations

    • Department of Epidemiology, Jagiellonian University, Krakow, Poland
    • ,
  • Justyna Kozub

      Affiliations

    • Department of Radiology, Jagiellonian University, Krakow, Poland
    • ,
  • Barbara Sobiecka

      Affiliations

    • Department of Radiology, Jagiellonian University, Krakow, Poland
    • ,
  • Andrzej Urbanik

      Affiliations

    • Department of Radiology, Jagiellonian University, Krakow, Poland
    • ,
  • Andrzej Szczudlik

      Affiliations

    • Department of Neurology, Institute of Neurology, Jagiellonian University, Krakow, Poland

Received 18 August 2004 ,Revised 5 May 2005 ,Accepted 2 June 2005.

Reference 

  1. Okada K, Kobayashi S, Yamagata S, Takahashi K, Yamaguchi S. Poststroke apathy and regional cerebral blood flow. Stroke. 1997;28:2437–2441
  2. Starkstein SE, Fedoroff JP, Price TR, Leiguarda R, Robinson RG. Apathy following cerebrovascular lesions. Stroke. 1993;24:1625–1630
  3. Babinski J. Contriburion a 1'etude des troubles mentaux dans l'hemiplegie organique cerebrale (anosognosie). Rev Neurol (Paris). 1914;27:845–848
  4. Kant R, Duffy JD, Pivovarnik A. Prevalence of apathy following head injury. Brain Inj. 1998;12:87–92
  5. Kuzis G, Sabe L, Tiberti C, Dorrego F, Starkstein SE. Neuropsychological correlates of apathy and depression in patients with dementia. Neurology. 1999;52:1403–1407
  6. Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG. Reliability, validity, and clinical correlates of apathy in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 1992;4:134–139
  7. Marin RS. Apathy: concept, syndrome, neural mechanisms, and treatment. Semin Clin Neuropsychiatry. 1996;1:304–314
  8. Marin RS. Differential diagnosis and classification of apathy. Am J Psychiatry. 1990;147:22–30
  9. Frith CD, Friston K, Liddle PF, Frackowiak RS. Willed action and the prefrontal cortex in man: a study with PET. Proc R Soc Lond Ser B Biol Sci. 1991;244:241–246
  10. Craig AH, Cummings JL, Fairbanks L, Laurent I, Miller BL, Jenny MI. Cerebral blood flow correlates of apathy in Alzheimer disease. Arch Neurol. 1996;53:1116–1120
  11. Mathews VP, Barker PB, Blackband SJ, Chatham JC, Bryan RN. Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy. Am J Radiol. 1995;165:633–638
  12. Wardlaw JM, Marshall I, Wild J, Dennis MS, Cannon J, Lewis SC. Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: realtion between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome. Stroke. 1998;29:1618–1624
  13. Petroff OAC, Graham GD, Blamire AM, al-Rayess M, Rothmann DL, Fayad PB, et al. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology. 1992;42:1349–1354
  14. Federico F, Simone IL, Lucivero V, Giannini P, Laddomada G, Mezzapesa DM, et al. Prognostic value of proton magnetic spectroscopy in ischemic stroke. Arch Neurol. 1998;55:489–494
  15. Graham GD, Kalvach P, Blamire AM, Brass M, Fayad PB, Prichard JW. Clinical correlates of proton magnetic resonance spectroscopy findings after acute cerebral infarction. Stroke. 1995;26:225–229
  16. Pereira AC, Saunders DE, Doyle VL, Bland JM, Howe FA, Griffiths JR, et al. Measurement of initial N-acetyl aspartate concentration by magnetic resonance spectroscopy and initial infarct volume by MRI predicts outcome in patients with middle cerebral artery territory infarction. Stroke. 1999;30:1577–1582
  17. Pendlebury ST, Blamire AM, Lee MA, Styles P, Matthews PM. Axonal injury in the internal capsule correlates with motor impairment after stroke. Stroke. 1999;30:956–962
  18. Kang DW, Roh JK, Lee YS, Song CI, Yoon W, Chang KH. Neuronal metabolic changes in the cortical region after subcortical infarction: a proton MR spectroscopy study. J Neurol Neurosurg Psychiatry. 2000;69:222–227
  19. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet. 1991;337:1521–1526
  20. Jorm AF, Jacomb PA. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med. 1989;19:1015–1022
  21. Marin RS. Apathy-who cares? An introduction to apathy and related disorders of diminished motivation. Psychiatr Ann. 1997;27:18–23
  22. Jacewicz-Kramarz H, Warnecka-Przybylska M. Contribution to the discussion on the etiology of apathic-abulic syndromes. Psychiatr Pol. 1982;16:145–149
  23. Marin RS, Biedrzycki RC, Firinciogullari S. Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res. 1991;38:143–162
  24. Cummings JL. The neuropsychiatric inventory: assessing psychopathology in dementia patients. Neurology. 1997;48(Suppl. 6):S10–S11
  25. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62
  26. Valenzuela MJ, Sachdev P. Magnetic resonance spectroscopy in AD. Neurology. 2001;56:592–598
  27. Birken DL, Oldendorf WH. N-acetyl-l-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of Brain. Neurosci Biobehav Rev. 1989;13:23–31
  28. Nakano M, Ueda H, Li J, Matsumoto M, Yanagiha T. Measurements of regional N-acetylaspartate after transient global amnesia in gerbils with and without ischemic tolerance: an index of neuronal survival. Ann Neurol. 1998;44:334–340
  29. Sager T, Hansen A, Laursen H. Correlation between N-acetylaspartate levels and histopathological changes in cortical infarcts after middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2000;20:780–788
  30. Delamillieure P, Fernandez J, Constans JM, Brazo P, Benali K, Abadie P, et al. Proton magnetic resonance spectroscopy of the medial prefrontal cortex in patients with deficit schizophrenia: preliminary report. Am J Psychiatry. 2000;157:641–643
  31. House A, Dennis M, Mogridge L, Warlow C, Hawton K, Jones L. Mood disorders in the year after first stroke. Br J Psychiatry. 1991;158:83–92
  32. Ready RE, Ott BR, Grace J, Cahn-Weiner DA. Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry. 2003;11:222–228
  33. Daffner KR, Mesulam MM, Scinto LF, Acar D, Calvo V, Faust R, et al. The central role of the prefrontal cortex in directing attention to novel events. Brain. 2000;123:927–939
  34. Daffner KR, Renz DM, Scinto LFM, Faust R, Budson AE, Holcomb PJ. Pathophysiology underlying diminished attention to novel events in patients with early AD. Neurology. 2001;56:1377–1383
  35. Hier DB, Stein RW. Deficits from infarction of the nondominant hemisphere. In: Stroke, pathophysiology, diagnosis, and management. vol. 1:New York: Churchill Livingstone Inc.; 1986;p. 421–437
  36. Weinberg I. The prisoners of despair: right hemisphere deficiency and suicide. Neurosci Biobehav Rev. 2000;24:799–815

PII: S0022-510X(05)00222-4

doi: 10.1016/j.jns.2005.06.004

Journal of the Neurological Sciences
Volume 238, Issue 1 , Pages 19-24 , 15 November 2005

Article Tools

* Image Usage & Resolution