Journal of the Neurological Sciences
Volume 229 , Pages 37-41 , 15 March 2005

Prevalence and pathogenic role of cerebrovascular lesions in Alzheimer disease

  • Kurt A. Jellinger

      Affiliations

    • Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 5266534; fax: +43 1 5238634.
    • ,
  • Johannes Attems

      Affiliations

    • Department of Pathology, Otto Wagner Hospital, Vienna, Austria

References 

  1. Du AT, Schuff N, Laakso MP, Zhu XP, Jagust WJ, Yaffe K, et al. Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus. Neurology. 2002;58:1635–1641
  2. Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet. 1999;354:919–920
  3. Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J. Neural. Transm. 2002;109:813–836
  4. de la Torre JC. Alzheimer's disease: how does it start?. J. Alzheimers Dis. 2002;4:497–512
  5. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277:813–817
  6. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N. Engl. J. Med. 2003;348:1215–1222
  7. Zekry D, Duyckaerts C, Moulias R, Belmin J, Geoffre C, Herrmann F, et al. Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol. (Berl.). 2002;103:481–487
  8. Zekry D, Duyckaerts C, Belmin J, Geoffre C, Herrmann F, Moulias R, et al. The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy. Neurobiol. Aging. 2003;24:213–219
  9. Crystal H, Dickson D. Cerebral infarcts in patients with autopsy proven Alzheimer's disease. Neurobiol. Aging. 2002;23:207;[abstr.]
  10. Etiene D, Kraft J, Ganju N, Gomez-Isla T, Gemelli B, Hyman BT, et al. Cerebrovascular pathology contributes to the heterogeneity of Alzheimer's disease. J. Alzheimers Dis. 1998;1:119–134
  11. Heyman A, Fillenbaum GG, Welsh-Bohmer KA, Gearing M, Mirra SS, Mohs RC, et al. Cerebral infarcts in patients with autopsy-proven Alzheimer's disease, CERAD, Part XVIII. Neurology. 1998;51:159–162[abstr.]
  12. Kalaria R. Similarities between Alzheimer's disease and vascular dementia. J. Neurol. Sci. 2002;203–204:29–34
  13. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet. 2001;357:169–175
  14. Petrovich H, Ross GW, Steinhorn SC, Abbott RD, Markesberry W, Davis DG, et al. AD lesions and infarcts in demented and no-demented Japanese-American men. Ann Neurol in press.
  15. Lee JH, Olichney JM, Hansen LA, Hofstetter CR, Thal LJ. Small concomitant vascular lesions do not influence rates of cognitive decline in patients with Alzheimer disease. Arch. Neurol. 2000;57:1474–1479
  16. Mungas D, Reed BR, Ellis WG, Jagust WJ. The effects of age on rate of progression of Alzheimer disease and dementia with associated cerebrovascular disease. Arch. Neurol. 2001;58:1243–1247
  17. Nagy Z, Esiri MM, Jobst KA, Morris JH, King E-F, McDonald B, et al. The effects of additional pathology on the cognitive deficit in Alzheimer Disease. J. Neuropathol. Exp. Neurol. 1997;56:165–170
  18. Jellinger KA, Mitter-Ferstl E. The impact of cerebrovascular lesions in Alzheimer disease. A comparative autopsy study. J. Neurol. 2003;252:1050–1055
  19. Jellinger KA, Attems J. Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study. Acta Neuropathol. (Berl.). 2003;105:14–17
  20. Cadavid D, Mena H, Koeller K, Frommelt RA. Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction. A case control study in human brain biopsies. J. Neuropathol. Exp. Neurol. 2000;59:768–773
  21. Olichney JM, Hansen LA, Hofstetter CR, Grundman M, Katzman R, Thal LJ. Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension. Arch. Neurol. 1995;52:702–708
  22. Olichney JM, Ellis RJ, Katzman R, Sabbagh MN, Hansen L. Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease. Ann. N. Y. Acad. Sci. 1997;826:493–497
  23. Revesz T, Ghiso J, Lashley T, Plant G, Rostagno A, Frangione B, et al. Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view. J. Neuropathol. Exp. Neurol. 2003;62:885–898
  24. Thal DR, Dhebremedhin E, Orantes M, Wiestler OD. Small vessel lesions related to cerebral amyloid angiopathy (CAA) and arteriosclerosis/lipohylinosis (AS/LH) are associated with Alzheimer disease. Brain Pathol. 2003;13(Suppl. 1):S7–S8[abstr.]
  25. Jellinger KA. Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study. Acta Neuropathol. (Berl.). 2003;105:415–419
  26. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41:479–486
  27. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.). 1991;82:239–259
  28. Hyman BT. New neuropathological criteria for Alzheimer disease. Arch. Neurol. 1998;55:1174–1176
  29. Attems J, Jellinger KA. Capillary cerebral amyloid angiopathy correlates with Alzheimer disease neuropathology. Acta Neuropathol. (Berl.). 2004;111:1219–1235
  30. Love S, Nicoll JA, Hughes A, Wilcock GK. APOE and cerebral amyloid angiopathy in the elderly. NeuroReport. 2003;14:1535–1536
  31. Thal DR, Ghebremedhin E, Rub U, Yamaguchi H, Tredici KD, Braak H. Two types of sporadic cerebral amyloid angiopathy. J. Neuropathol. Exp. Neurol. 2002;61:282–293
  32. Preston SD, Steart PV, Wilkinson A, Nicoll JA, Weller RO. Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol. Appl. Neurobiol. 2003;29:106–117
  33. Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am. J. Pathol. 1998;153:725–733
  34. Weller RO, Massey A, Kuo YM, Roher AE. Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease. Ann. N. Y. Acad. Sci. 2000;903:110–117
  35. Roher AE, Kuo YM, Esh C, Knebel C, Weiss N, Kalback W, et al. Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease. Mol. Med. 2003;9:112–122
  36. Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 2003;9:448–452
  37. Honig LS, Tang MX, Albert S, Costa R, Luchsinger J, Manly J, et al. Stroke and the risk of Alzheimer disease. Arch. Neurol. 2003;60:1707–1712

PII: S0022-510X(04)00440-X

doi: 10.1016/j.jns.2004.11.018

Journal of the Neurological Sciences
Volume 229 , Pages 37-41 , 15 March 2005

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