Journal of the Neurological Sciences
Volume 229 , Pages 89-93 , 15 March 2005

Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study

  • L.M. Waite

      Affiliations

    • Centre for Education and Research on Ageing, C25, Concord Hospital, University of Sydney, Concord NSW 2139, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 2 9767 7278; fax: +61 2 9767 5419.
    • ,
  • D.A. Grayson

      Affiliations

    • School of Psychology, University of Sydney, Australia
    • ,
  • O. Piguet

      Affiliations

    • Prince of Wales Medical Research Institute and the University of New South Wales, Australia
    • ,
  • H. Creasey

      Affiliations

    • Centre for Education and Research on Ageing, C25, Concord Hospital, University of Sydney, Concord NSW 2139, Australia
    • ,
  • H.P. Bennett

      Affiliations

    • Prince of Wales Medical Research Institute and the University of New South Wales, Australia
    • ,
  • G.A. Broe

      Affiliations

    • Prince of Wales Medical Research Institute and the University of New South Wales, Australia
    • Prince of Wales Hospital, Randwick, Australia

References 

  1. Petersen R, Smith GE, Waring SC, Ivnik RJ, Kokmen E, Tangelos EG. Mild cognitive impairment: clinical characterisation and outcome. Arch. Neurol. 1999;56:303–308
  2. Petersen RC, Doody R, Kurz A, Mohs R, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch. Neurol. 2001;58:1985–1992
  3. Ritchie K, Touchon J. Mild cognitive impairment: conceptual basis and current nosological status. Lancet. 2000;355:225–228
  4. Bennett DA, Beckett LA, Murray AM, Shannon KM, Goetz CG, Pilgrim DM, et al. Prevalence of parkinsonian signs and associated mortality in a community population of older people. New Engl. J. Med. 1996;334:71–76
  5. Mitchell SL, Rockwood K. The association between parkinsonism, Alzheimer's disease, and mortality. J. Am. Geriatr. Soc. 2000;48:422–425
  6. Richards M, Touchon J, Ledesert B, Ritchie K. Mild extrapyramidal signs and functional impairment in ageing. Int. J. Geriatr. Psychiatry. 2002;17:150–153
  7. Richards M, Stern Y, Mayeux R. Subtle extrapyramidal signs can predict the development of dementia in elderly individuals. Neurology. 1993;43:2184–2188
  8. Richards M, Stern Y, Mayeux R. Subtle extrapyramidal signs and incident dementia: follow-up analysis. Neurology. 1995;45:1942
  9. Waite LM, Broe GA, Grayson DA, Creasey H. Preclinical syndromes predict dementia: the Sydney Older Persons Study. J. Neurol. Neurosurg. Psychiatry. 2001;71:296–302
  10. Wilson RS, Schneider JA, Beckett LA, Evans DA, Bennett DA. Progression of gait disorder and risk of death in older persons. Neurology. 2002;58:1815–1819
  11. Verghese J, Lipton RB, Hall CB, Kuslansky G, Katz MJ, Buschke H. Abnormality of gait as a predictor of non-Alzheimer's dementia. New Engl. J. Med. 2002;347:1761–1768
  12. Marquis S, Moore MM, Howieson DB, Sexton G, Payami H, Kaye JA, et al. Independent predictors of cognitive decline in healthy elderly persons. Arch. Neurol. 2002;59:601–606
  13. Waite LM, Broe GA, Creasey H, Grayson D, Edelbrock D, O'Toole B. Neurological signs, aging and the neurodegenerative syndromes. Arch. Neurol. 1996;53:498–502
  14. Waite LM, Broe GA, Creasey H, Grayson DA, Cullen JS, O'Toole B, et al. Neurodegenerative and other chronic disorders among people aged 75 years and over in the community. Med. J. Aust. 1997;167:429–432
  15. Creasey H, Waite LM, Grayson DA, Bennett HP, Broe GA. The impact of neurodegenerative disorders on ageing. Aust. J. Ageing. 2001;20:10–16
  16. Piguet O, Grayson DA, Creasey H, Bennett HP, Brooks WS, Waite LM, et al. Vascular risk factors, cognition and dementia incidence over 6 years in the Sydney Older Persons Study. Neuroepidemiology. 2003;22:165–171
  17. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed. revised. Washington, DC: APA; 1987;
  18. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed.. Washington, DC: APA; 1994;
  19. Waite L, Grayson D, Jorm AF, Creasey H, Cullen J, Bennett H, et al. Informant-based staging of dementia using the clinical dementia rating. Alzheimer Dis. Assoc. Disord. 1999;13:34–37
  20. Piguet O, Ridley L, Grayson DA, Bennett HP, Creasey H, Lye TC, et al. Are MRI white matter lesions clinically significant in the “old–old”? Evidence from the Sydney Older Persons Study. Dement. Geriatr. Cogn. Disord. 2003;15:143–150
  21. Kurlan R, Richard IH, Papka M, Marshall F. Movement disorders in Alzheimer's disease: more rigidity of definitions is needed. Mov. Disord. 2000;15:24–29
  22. Yamanouchi H, Hiroshi N. Neurological signs and frontal white matter lesions in vascular parkinsonism: a clinicopathologic study. Stroke. 1997;28:965–969
  23. Piccini P, Pavese N, Canapicchi R, Paoli C, Del Dotto P, Puglioli M, et al. White matter hyperintensities in Parkinson's disease. Clinical correlations. Arch. Neurol. 1995;52:191–194
  24. Fitzgerald PM, Jankovic J. Lower body parkinsonism: evidence for a vascular aetiology. Mov. Disord. 1989;4:249–260
  25. Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson L, Nilsson L, et al. 15-Year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–1145
  26. De Carli C. Mild cognitive impairment: prevalence, prognosis, etiology and treatment. Lancet Neurol. 2003;2:15–21
  27. Lopez OL, Wisnieski SR, Becker JT, Boller F, DeKosky ST. Extrapyramidal signs in patients with probable Alzheimer disease. Arch. Neurol. 1997;54:969–975

PII: S0022-510X(04)00431-9

doi: 10.1016/j.jns.2004.11.009

Journal of the Neurological Sciences
Volume 229 , Pages 89-93 , 15 March 2005

Article Tools