Journal of the Neurological Sciences
Volume 226, Issue 1 , Pages 71-74 , 15 November 2004

Prevention of dementia: lessons from SYST-EUR and PROGRESS

References 

  1. Elias MF, Wolf PA, d'Agostino RB, Cobb J, White LR. Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. Am. J. Epidemiol. 1993;138:353–364
  2. Kilander L, Nyman H, Boberg M, Hansson L, Lithell H. Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men. Hypertension. 1998;31:780–786
  3. Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, et al. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology. 2001;56:42–48
  4. Skoog I, Lernfelt B, Landahl S, et al. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–1145
  5. Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, et al. Midlife blood pressure and dementia: the Honolulu–Asia aging study. Neurobiol. Aging. 2000;21:49–55
  6. Tzourio C, Dufouil C, Ducimetiere P, Alperovitch A. Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. EVA Study Group. Epidemiology of Vascular Aging. Neurology. 1999;53:1948–1952
  7. Murray MD, Lane KA, Gao S, Evans RM, Unverzagt FW, Hall KS, et al. Preservation of cognitive function with antihypertensive medications: a longitudinal analysis of a community-based sample of African Americans. Arch. Intern. Med. 2002;162:2090–2096
  8. Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's treatment trial of hypertension in older adults. BMJ. 1996;312:801–805
  9. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265:3255–3264
  10. Di Bari M, Pahor M, Franse LV, Shorr RI, Wan JY, Ferrucci L, et al. Dementia and disability outcomes in large hypertension trials: lessons learned from the Systolic Hypertension in the Elderly Program (SHEP) Trial. Am. J. Epidemiol. 2001;153:72–78
  11. Forette F, Seux M-L, Staessen JA, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet. 1998;352:1347–1351
  12. Tzourio C, Anderson C, Chapman N, Woodward M, Neal B, MacMahon S, et al. PROGRESS Collaborative Group. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch. Intern. Med. 2003;12;163:1069–1075
  13. Forette F, Seux ML, Staessen JA, Thijs L, Babarskiene MR, Babeanu S, et al. Systolic Hypertension in Europe Investigators. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch. Intern. Med. 2002;162:2046–2052
  14. Khachaturian ZS. Calcium hypothesis of Alzheimer's disease and brain aging. Ann. N.Y. Acad. Sci. 1994;747:1–11
  15. Mason RP, Leeds PR, Jacob RF, Hough CJ, Zhang KG, Mason PE, et al. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. J. Neurochem. 1999;72:1448–1456
  16. Zipfel GJ, Lee JM, Choi DW. Reducing calcium overload in the ischemic brain. N. Engl. J. Med. 1999;341:1543–1544
  17. Kawahara M, Kuroda Y. Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol. Cell. Mol. Neurobiol. 2001;21:1–13
  18. O'Neill C, Cowburn RF, Bonkale WL, Ohm TG, Fastbom J, Carmody M, et al. Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease. Biochem. Soc. Symp. 2001;67:177–194
  19. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 1992;12:376–389
  20. Veinbergs I, Everson A, Sagara Y, Masliah E. Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J. Neurosci. Res. 2002;67:379–387
  21. Mattson MP, Zhu H, Yu J, Kindy MS. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 2000;20:1358–1364
  22. Sabbatini M, Mignini F, Venarucci D, Vega JA, Amenta F. Effect of nicardipine treatment on the expression of neurofilament 200 kDa immunoreactivity in the brain of spontaneously hypertensive rats. Clin. Exp. Hypertens. 2001;23:127–141
  23. Farkas E, De Jong GI, Apro E, Keuker JI, Luiten PG. Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain. Neurobiol. Aging. 2001;22:299–309
  24. Vagnucci AH, Li WW. Alzheimer's disease and angiogenesis. Lancet. 2003;361:605–608

PII: S0022-510X(04)00297-7

doi: 10.1016/j.jns.2004.09.015

Journal of the Neurological Sciences
Volume 226, Issue 1 , Pages 71-74 , 15 November 2004