Journal of the Neurological Sciences
Volume 226, Issue 1 , Pages 71-74, 15 November 2004

Prevention of dementia: lessons from SYST-EUR and PROGRESS

Department of Geriatrics, Hôpital Broca, CHU Cochin Port-Royal, Université René Descartes, Paris V, 54/56 Rue Pascal, 75013 Paris, France

Abstract 

Hypertension is one of the principal risk factors for cerebrovascular diseases, closely correlated also with cognitive decline and dementia. Data from recent therapeutic trials (SYST-EUR, PROGRESS) open the way toward the prevention of dementia (vascular or Alzheimer's type) by antihypertensive treatments. The results of these two studies suggest different mechanisms of action of antihypertensive drugs in the prevention of cognitive decline. The use of angiotensin converting enzyme (ACE) inhibitors, with or without diuretics, resulted in decrease incidence of stroke-related dementia, but dementia without stroke was not reduced. With the dihydropyridine calcium antagonists, a reduction in both Alzheimer's type and vascular dementia was demonstrated.

Keywords: Hypertension, Cognitive decline, Dementia, Antihypertensive drugs, Calcium channel blocker

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0022-510X(04)00297-7

doi:10.1016/j.jns.2004.09.015

Journal of the Neurological Sciences
Volume 226, Issue 1 , Pages 71-74, 15 November 2004

Article Tools

* Image Usage & Resolution