Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

Sohmiya, Makoto; Tanaka, Makoto; Wei Tak, Nyou; Yanagisawa, Makoto; Tanino, Yutaka; Suzuki, Yoko; Okamoto, Koichi; Yamamoto, Yorihiro

doi:10.1016/j.jns.2004.05.007

« Previous Next »Journal of the Neurological Sciences
Volume 223, Issue 2 , Pages 161-166, 30 August 2004

Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

Makoto Sohmiya
- Corresponding author. Tel.: +81-27-220-8061; fax: +81-27-220-8068.
- Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan
Makoto Tanaka
- Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan
Nyou Wei Tak
- Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan
Makoto Yanagisawa
- Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan
Yutaka Tanino
- School of Bionics, Tokyo University of Technology, 1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan
Yoko Suzuki
- Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan
Koichi Okamoto
- Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan
Yorihiro Yamamoto
- School of Bionics, Tokyo University of Technology, 1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan

Received 21 July 2003; received in revised form 20 February 2004; accepted 11 May 2004.

Abstract

Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients.

Keywords: Parkinson's disease, Oxidative stress, Plasma, Redox status, Coenzyme Q10, Antioxidant