Journal of the Neurological Sciences
Volume 222, Issue 1 , Pages 55-57, 15 July 2004

Effect of a 0.5-T static magnetic field on conduction in guinea pig spinal cord

  • Abigail Coots

      Affiliations

    • Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    • ,
  • Riyi Shi

      Affiliations

    • Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN, USA
    • ,
  • Arthur D Rosen

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-765-496-2098; fax: +1-765-494-0876.
    • Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA

Received 6 February 2004; accepted 5 April 2004.

Abstract 

Compound-evoked potentials were recorded from excised adult guinea pig spinal cords before, during, and following exposure to a 0.5-T static magnetic field (SMF). There was no change in response latency during exposure but there was a small, statistically significant, decrease in amplitude. Maximum effect was evident 1 to 2 min after the field was turned on with return to baseline within 1 min after the field was turned off. These results may be explained by a conduction block in the small axon subpopulation due to the effect of static magnetic fields on voltage-activated sodium channels. The relative selectivity of the field is believed to occur because of the relatively greater number of sodium channels present in smaller axons.

Keywords:  Static magnetic field, Sodium channels, Spinal cord

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PII: S0022-510X(04)00105-4

doi:10.1016/j.jns.2004.04.010

Journal of the Neurological Sciences
Volume 222, Issue 1 , Pages 55-57, 15 July 2004

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