Journal of the Neurological Sciences
Volume 222, Issue 1 , Page 1 , 15 July 2004

Interferon-beta therapy for MS: the dilemma of having choices

  • Omar Khan

      Affiliations

    • Corresponding Author InformationTel.: +1-313-745-4886; fax: +1-313-745-4216.

Received 28 January 2004 ,Accepted 30 January 2004.

References 

  1. Barbero P, Verdun E, Bergui M, et al. JNS 2004.
  2. The Once Weekly Interferon for MS Study Group . Evidence for interferon β-1a dose response in relapsing–remitting MS. The OWIMS Study. Neurology. 1999;53:679–686
  3. Khan OA, Tselis AC, Kamholz JA, Garbern JY, Lewis RA, Lisak RP. A Prospective, Open-Label Treatment Trial to Compare the Effect of IFN beta-1a (Avonex), IFN beta-1b (Betaseron), and Glatiramer Acetate (Copaxone) on the Relapse Rate in Relapsing–Remitting Mult. Scler.: Results after 18 Months of Therapy. Mult. Scler. 2001;7:349–353
  4. Panitch H, Goodin DS, Francis G, et al.  Randomized, comparative study of interferon β-1a treatment regimens in MS. The EVIDENCE Trial. Neurology. 2002;59:1496–1506
  5. Durrelli L, Verdun E, Barbero P, et al.  Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomized multicentre study (INCOMIN). Lancet. 2002;359:1453–1460
  6. Clanet M, Radue EW, Kappos L, et al.  A randomized, double-blind, dose-comparison study of weekly interferon β-1a in relapsing MS. Neurology. 2002;59:1507–1517
  7. Rothuizen LE, Budin T, Spertilini F, et al.  Influence of interferon beta-1a frequency on PBMC cytokine secretion and biological effect markers. J. Neuroimmunol. 1999;99:131–141
  8. Goodin DS, Frohman EM, Garmany GP, et al.  Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology. 2002;58:169–178

PII: S0022-510X(04)00090-5

doi: 10.1016/j.jns.2004.01.016

Journal of the Neurological Sciences
Volume 222, Issue 1 , Page 1 , 15 July 2004

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