Journal of the Neurological Sciences
Volume 222, Issue 1 , Pages 3-5 , 15 July 2004

A plea for “Omics” research in complex diseases such as multiple sclerosis—a change of mind is needed

  • Roland Martin

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-301-402-4488; fax: +1-301-402-0373.
    • Neuroimmunology Branch, NINDS, National Institutes of Health, 10 Center DR MSC 1400, Bethesda, MD 20892-1400, USA
    • ,
  • David Leppert

      Affiliations

    • Clinical Neuroimmunology Laboratory, Departments of Research and Neurology, University Hospitals Basel, Klingerbergstrasse 50, CH-4056 Basel, Switzerland

Received 24 February 2004 ,Accepted 24 February 2004.

References 

  1. The Multiple Sclerosis Genetics Group Barcellos LF, Oksenberg JR, Green AJ, Bucher P, Rimmler JB, Schmidt S, et al.  Genetic basis for clinical expression in multiple sclerosis. Brain. 2002;125:150–158
  2. Wiendl H, Hohlfeld R. Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs. 2002;16(3):183–200
  3. The Lenercept Multiple Sclerosis Study Group the University of British Columbia MS/MRI Analysis Group . TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology. 1999;53(3):457–465
  4. Panitch HS, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1987 (Apr. 18);1(8538):893–895
  5. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, et al.  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002 (May);8(5):500–508
  6. Bomprezzi R, Ringner M, Kim S, Bittner ML, Khan J, Chen Y, et al.  Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum. Mol. Genet. 2003 (Sep. 1);12(17):2191–2199
  7. Whitney LW, Ludwin SK, McFarland HF, Biddison WE. Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions. J. Neuroimmunol. 2001 (Dec. 3);121(1–2):40–48
  8. Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, et al.  Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 1999 (Sep.);46(3):425–428
  9. Mycko MP, Papoian R, Boschert U, Raine CS, Selmaj KW. cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain. 2003;126:1048–1057
  10. GAMES (Genetic Analysis of Multiple Sclerosis in EuropeanS) the Transatlantic Multiple Sclerosis Genetics Cooperative . A meta-analysis of whole genome linkage screens in multiple sclerosis. J. Neuroimmunol. 2003 (Oct.);143(1–2):39–46

PII: S0022-510X(04)00056-5

doi: 10.1016/j.jns.2004.02.013

Journal of the Neurological Sciences
Volume 222, Issue 1 , Pages 3-5 , 15 July 2004

Article Tools