Journal of the Neurological Sciences
Volume 217, Issue 1 , Pages 7-12 , 15 January 2004

Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients

  • Takashi Oide

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Takahiko Tokuda

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-263-37-2673; fax: +81-263-34-0929.
    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Masahide Yazaki

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Megumi Watarai

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Shigeaki Mitsuhashi

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Kazuma Kaneko

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Takao Hashimoto

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
    • ,
  • Shinji Ohara

      Affiliations

    • Department of Neurology, National Chushin-Matsumoto Hospital, 811 Kotobuki, Matsumoto 399-0021, Japan
    • ,
  • Shu-ichi Ikeda

      Affiliations

    • Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan

Received 26 March 2003 ,Revised 1 August 2003 ,Accepted 4 August 2003.

References 

  1. Sanders V. Neurologic manifestations of myxedema. N. Engl. J. Med. 1962;266:547–552
  2. Brain L, Jellinek EH, Ball K. Hashimoto's disease and encephalopathy. Lancet. 1966;7462:512–514
  3. Henderson LM, Behan PO, Aarli J, Hadley D, Draper IT. Hashimoto's encephalopathy: a new neuroimmunological syndrome. Ann. Neurol. 1987;22:140–141
  4. Shaw PJ, Walls TJ, Newman PK, Cleland PG. Cartlidge NEF. Hashimoto's encephalopathy: a steroid responsive disorder associated with high anti-thyroid antibody titers. Report of 5 cases. Neurology. 1991;41:228–233
  5. Henchey R, Cibula J, Helveston W, Malone J, Gilmore RL. Electroencephalographic findings in Hashimoto's encephalopathy. Neurology. 1995;45:977–981
  6. Ghika-Schmid F, Ghika J, Regli F, Dworak N, Bogousslavsky J, Städler C, et al.  Hashimoto's myoclonic encephalopathy: an underdiagnosed treatable condition?. Mov. Disord. 1996;11:555–562
  7. Kothbauer-Margreiter I, Sturzenegger M, Komor J, Baumgartner R, Hess CW. Encephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment. J. Neurol. 1996;243:585–593
  8. Peschen-Rosin R, Schabet M, Dichgans J. Manifestation of Hashimoto's encephalopathy years before onset of thyroid disease. Eur. Neurol. 1999;41:79–84
  9. Galluzzi S, Geroldi C, Zanetti O, Frisoni GB. Hashimoto's encephalopathy in the elderly: relationship to cognitive impairment. J. Geriatr. Psychiatry Neurol. 2002;15:175–179
  10. Forchetti CM, Katsamakis G, Garron DC. Autoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism. Neurology. 1997;49:623–626
  11. Seipelt M, Zerr I, Nau R, Mollenhauer B, Kropp S, Steinhoff BJ, et al.  Hashimoto's encephalitis as a differential diagnosis of Creutzfeldt–Jakob disease. J. Neurol. Neurosurg. Psychiatry. 1999;66:172–176
  12. Doherty CP, Schlossmacher M, Torres N, Bromfield E, Samuels MA. Hashimoto's encephalopathy mimicking Creutzfeldt–Jakob disease: brain biopsy findings. J. Neurol. Neurosurg. Psychiatry. 2002;73:601–602
  13. Kaneko K, Nakamura A, Yoshida K, Kametani F, Higuchi K, Ikeda S. Grial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain. Free Radic. Res. 2002;36:303–306
  14. Shin R-W, Iwaki T, Kitamoto T, Tateishi J. Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues. Lab. Invest. 1991;64:693–702
  15. Flynn SD, Nishiyama RH, Bigos ST. Autoimmune thyroid disease: immunological, pathological, and clinical aspects. Crit. Rev. Clin. Lab. Sci. 1988;26:43–95
  16. Thrush DC, Boddie HG. Episodic encephalopathy associated with thyroid disorders. J. Neurol. Neurosurg. Psychiatry. 1974;37:696–700
  17. Nolte KW, Unbehaun A, Sieker H, Kloss TM, Paulus W. Hashimoto encephalopathy: a brainstem vasculitis?. Neurology. 2000;54:769–770
  18. Shein M, Apter A, Dickerman Z, Tyano S, Gadoth N. Encephalopathy in compensated Hashimoto thyroiditis: a clinical expression of autoimmune cerebral vasculitis. Brain Dev. 1986;8:60–64
  19. Takahashi S, Mitamura R, Itoh Y, Suzuki N, Okuno A. Hashimoto encephalopathy: etiologic considerations. Pediatr. Neurol. 1994;11:328–331
  20. Perrot X, Giraud P, Biacabe A-G, Perret-Liaudet A, Borson-Chazot F, Gray F, et al.  Hashimoto's encephalopathy: an anatomicoclinical observation. Rev. Neurol. (Paris). 2002;158:461–466
  21. Cupps TR, Moore PM, Fauci AS. Isolated angiitis of the central nervous system. Prospective diagnostic and therapeutic experience. Am. J. Med. 1983;74:97–105
  22. Calabrese LH, Mallek JA. Primary angiitis of the central nervous system. Report of 8 new cases, review of the literature, and proposal for diagnostic criteria. Medicine (Baltimore). 1987;67:20–39
  23. Hurst RW, Grossman RI. Neuroradiology of central nervous system vasculitis. Semin. Neurol. 1994;14:320–340
  24. Ehsan T, Hasan S, Powers JM, Heiserman E. Serial magnetic resonance imaging in isolated angiitis of the central nervous system. Neurology. 1995;45:1462–1465
  25. Bostantjopoulou S, Zafiriou D, Katsarou Z, Kazis A. Hashimoto's encephalopathy: clinical and laboratory findings. Funct. Neurology. 1996;11:247–251
  26. Bohnen NILJ, Parnell KJ, Harper CM. Reversible MRI findings in a patient with Hashimoto's encephalopathy. Neurology. 1997;49:246–247
  27. McCabe DJH, Burke T, Connolly S, Hutchinson M. Amnestic syndrome with bilateral mesial temporal lobe involvement in Hashimoto's encephalopathy. Neurology. 2000;54:737–739
  28. Ochi H, Horiuchi I, Araki N, Toda T, Araki T, Sato K, et al.  Proteome analysis of human brain identifies α-enolase as a novel autoantigen in Hashimoto's encephalopathy. FEBS Lett. 2002;528:197–202
  29. Bianchi G, Marchesini G, Zoli M, Falasconi MC, Iervese T, Magalotti D, et al.  Thyroid involvement in chronic inflammatory rheumatological disorders. Clin. Rheumatol. 1994;13:479–484
  30. Miller FW, Moore GF, Weintraub BD, Steinberg AD. Prevalence of thyroid disease and abnormal thyroid function test results in patients with systemic lupus erythematosus. Arthritis Rheum. 1987;30:1124–1131
  31. Karsh J, Pavlidis N, Weintraub BD, Moutsopoulos HM. Thyroid disease in Sjögren's syndrome. Arthritis Rheum. 1980;23:1326–1329
  32. Betterle C, Greggio NA, Volpato M. Clinical review 93: autoimmune polygrandular syndrome type 1. J. Clin. Endocrinol. Metab. 1998;83:1049–1055

PII: S0022-510X(03)00241-7

doi: 10.1016/j.jns.2003.08.005

Journal of the Neurological Sciences
Volume 217, Issue 1 , Pages 7-12 , 15 January 2004

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