Journal of the Neurological Sciences
Volume 217, Issue 1 , Pages 13-15 , 15 January 2004

Association of α2-macroglobulin polymorphisms and Alzheimer disease in Mainland Han Chinese

  • Deng Chen

      Affiliations

    • National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences and The Peking Union Medical College, Beijing 100005, People's Republic of China
    • ,
  • Jun-Wu Zhang

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +86-10-65296423; fax: +86-10-65240529.
    • National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences and The Peking Union Medical College, Beijing 100005, People's Republic of China
    • ,
  • Zhen-Xin Zhang

      Affiliations

    • Department of Neurology, The Peking Union Hospital, The Chinese Academy of Medical Sciences and The Peking Union Medical College, Beijing, People's Republic of China
    • ,
  • Ya-Ning Wu

      Affiliations

    • National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences and The Peking Union Medical College, Beijing 100005, People's Republic of China
    • ,
  • Qiu-Ming Qu

      Affiliations

    • Department of Neurology, The First Affiliated Hospital, Xi'an Medical University, Shaanxi Province, People's Republic of China

Received 15 April 2003 ,Revised 1 August 2003 ,Accepted 4 August 2003.

References 

  1. Pericak-Vance MA, Bass MP, Yamaoka LH, et al.  Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA. 1997;278:1237–1241
  2. Matthijs G, Marynen P. A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene. Nucleic Acids Res. 1991;19:5102
  3. Poller W, Faber JP, Olek K. Sequence polymorphism in the human alpha-2-macroglobulin (A2M) gene. Nucleic Acids Res. 1991;19:198
  4. Blacker D, Wilcox MA, Laird NM, et al.  Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat. Genet. 1998;19:357–360
  5. Liao A, Nitsch RM, Greenberg SM, et al.  Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Hum. Mol. Genet. 1998;7:1953–1956
  6. Bagli M, Papassotiropoulos A, Jessen F, et al.  Identical distribution of the α2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population. Am. J. Med. Genet. 2000;96:775–777
  7. Shibata N, Ohnuma T, Takahashi T, et al.  No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease. Neurosci. Lett. 2000;290:154–156
  8. Dow DJ, Lindsey N, Cairns NJ, et al.  Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. Nat. Genet. 1999;22:16–17
  9. Wenham PR, Price WH, Blandell G. Apolipoprotein E genotyping by one-stage PCR. Lancet. 1991;337:1158–1159
  10. Nacmias B, Tedde A, Cellini E, et al.  Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease. Neurosci. Lett. 2001;299:9–12
  11. Zappia M, Cittadella R, Manna I, et al.  Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy. Neurology. 2002;59:756–758
  12. Hu CJ, Sung SM, Liu HC, et al.  No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese. Neurology. 1999;53:642–643
  13. Chen L, Baum L, Ng HK, et al.  Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease. Neurosci. Lett. 1999;269:173–177
  14. Tang G, Zhang M, Xie H, et al.  Alpha-2 macroglobulin I1000V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease. Neurosci. Lett. 2002;328:195–197

PII: S0022-510X(03)00239-9

doi: 10.1016/j.jns.2003.08.002

Journal of the Neurological Sciences
Volume 217, Issue 1 , Pages 13-15 , 15 January 2004

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